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H2AX protein, human

Known as: H2A/X, H2A.X, H2AX 
Histone H2AX (143 aa, ~15 kDa) is encoded by the human H2AFX gene. This protein plays a role in nucleosome formation and V(D)J recombination.
National Institutes of Health

Related topics

Related topics

11 relations
Cell NucleusDouble Strand Break RepairH2AFX geneH2AFX wt Allele

Broader (1)

Histones

Papers overview

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Highly Cited
2011
Highly Cited
2011
Spectrum of Cellular Responses to Pyriplatin, a Monofunctional Cationic Antineoplastic Platinum(II) Compound, in Human Cancer Cells
Pyriplatin, cis-diammine(pyridine)chloroplatinum(II), a platinum-based antitumor drug candidate, is a cationic compound with… 
Highly Cited
2009
Highly Cited
2009
Widespread Phosphorylation of Histone H2AX by Species C Adenovirus Infection Requires Viral DNA Replication
ABSTRACT Adenovirus infection activates cellular DNA damage response and repair pathways. Viral proteins that are synthesized… 
Highly Cited
2009
Highly Cited
2009
Phosphorylated H2AX foci in tumor cells have no correlation with their radiation sensitivities.
Ionizing radiation causes DNA double strand breaks (DSBs), which produce a chromosomal change with the modification of chromatin… 
2009
2009
Histone H2A.X Tyr142 phosphorylation: a novel sWItCH for apoptosis?
2009
2009
Inhibition of Expression of the Chromatin Remodeling Gene, SNF2L, Selectively Leads to DNA Damage, Growth Inhibition, and Cancer Cell Death
SNF2L, a chromatin remodeling gene expressed in diverse tissues, cancers, and derived cell lines, contributes to the chromatin… 
2008
2008
Oxidative stress induces cell cycle-dependent Mre11 recruitment, ATM and Chk2 activation and histone H2AX phosphorylation
DNA damage response recruits complex molecular machinery involved in DNA repair, arrest of cell cycle progression, and… 
Highly Cited
2006
Highly Cited
2006
Phosphorylated Histone H2AX Foci Persist on Rejoined Mitotic Chromosomes in Normal Human Diploid Cells Exposed to Ionizing Radiation
Abstract Suzuki, M., Suzuki, K., Kodama, S. and Watanabe M. Phosphorylated Histone H2AX Foci Persist on Rejoined Mitotic… 
Review
2005
Review
2005
DNA Repair in the Context of Chromatin
Modulation of chromatin is essential to nuclear processes that utilize DNA, such as transcription, replication, and repair. For… 
Highly Cited
2005
Highly Cited
2005
Sensitization of breast carcinoma cells to ionizing radiation by small molecule inhibitors of DNA-dependent protein kinase and ataxia telangiectsia mutated.
Highly Cited
2003
Highly Cited
2003
Comparison of checkpoint responses triggered by DNA polymerase inhibition versus DNA damaging agents.
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