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Cellular processing of platinum anticancer drugs
Cisplatin, carboplatin and oxaliplatin are platinum-based drugs that are widely used in cancer chemotherapy. Platinum–DNA adducts, which are formed following uptake of the drug into the nucleus ofExpand
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Structure, Recognition, and Processing of Cisplatin-DNA Adducts.
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The Ophiolite Of Northern Oman
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Direct cellular responses to platinum-induced DNA damage.
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Basis for recognition of cisplatin-modified DNA by high-mobility-group proteins
The anticancer activity of cis -diamminedichloroplatinum(II) (cisplatin) arises from its ability to damage DNA, with the major adducts formed being intrastrand d(GpG) and d(ApG) crosslinks. TheseExpand
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Organic cation transporters are determinants of oxaliplatin cytotoxicity.
Although the platinum-based anticancer drugs cisplatin, carboplatin, and oxaliplatin have similar DNA-binding properties, only oxaliplatin is active against colorectal tumors. The mechanisms for thisExpand
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Vesicular Zinc Promotes Presynaptic and Inhibits Postsynaptic Long-Term Potentiation of Mossy Fiber-CA3 Synapse
The presence of zinc in glutamatergic synaptic vesicles of excitatory neurons of mammalian cerebral cortex suggests that zinc might regulate plasticity of synapses formed by these neurons. Long-termExpand
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Crystal structure of a bacterial non-haem iron hydroxylase that catalyses the biological oxidation of methane
The 2.2 & Aring; crystal structure of the 251K α2β2γ2 dimeric hydroxylase protein of methane mono-oxygenase from Methylococcus capsulatus (Bath) reveals the geometry of the catalytic di-ironExpand
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Chemical Characterization of the Smallest S-Nitrosothiol, HSNO; Cellular Cross-talk of H2S and S-Nitrosothiols
Dihydrogen sulfide recently emerged as a biological signaling molecule with important physiological roles and significant pharmacological potential. Chemically plausible explanations for itsExpand
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Crystal structure of double-stranded DNA containing the major adduct of the anticancer drug cisplatin
THE success of cisplatin in cancer chemotherapy derives from its ability to crosslink DNA and alter the structure. Most cisplatiná¤-DNA adducts are intrastrand d(GpG) and d(ApG) crosslinks1, whichExpand
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