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- Publications
- Influence
Cellular processing of platinum anticancer drugs
- D. Wang, S. Lippard
- Biology, Medicine
- Nature Reviews Drug Discovery
- 1 April 2005
Cisplatin, carboplatin and oxaliplatin are platinum-based drugs that are widely used in cancer chemotherapy. Platinum–DNA adducts, which are formed following uptake of the drug into the nucleus of… Expand
Structure, Recognition, and Processing of Cisplatin-DNA Adducts.
- E. Jamieson, S. Lippard
- Chemistry, Medicine
- Chemical reviews
- 14 August 1999
Direct cellular responses to platinum-induced DNA damage.
- Y. Jung, S. Lippard
- Chemistry, Medicine
- Chemical reviews
- 25 April 2007
Basis for recognition of cisplatin-modified DNA by high-mobility-group proteins
- Uta-Maria Ohndorf, M. A. Rould, Q. He, C. Pabo, S. Lippard
- Biology, Medicine
- Nature
- 17 June 1999
The anticancer activity of cis -diamminedichloroplatinum(II) (cisplatin) arises from its ability to damage DNA, with the major adducts formed being intrastrand d(GpG) and d(ApG) crosslinks. These… Expand
Organic cation transporters are determinants of oxaliplatin cytotoxicity.
- Shuzhong Zhang, Katherine S. Lovejoy, +9 authors K. Giacomini
- Chemistry, Medicine
- Cancer research
- 1 September 2006
Although the platinum-based anticancer drugs cisplatin, carboplatin, and oxaliplatin have similar DNA-binding properties, only oxaliplatin is active against colorectal tumors. The mechanisms for this… Expand
Vesicular Zinc Promotes Presynaptic and Inhibits Postsynaptic Long-Term Potentiation of Mossy Fiber-CA3 Synapse
- E. Pan, Xiao-an Zhang, +5 authors J. McNamara
- Biology, Medicine
- Neuron
- 1 September 2011
The presence of zinc in glutamatergic synaptic vesicles of excitatory neurons of mammalian cerebral cortex suggests that zinc might regulate plasticity of synapses formed by these neurons. Long-term… Expand
Crystal structure of a bacterial non-haem iron hydroxylase that catalyses the biological oxidation of methane
- A. Rosenzweig, C. A. Frederick, S. Lippard, P38 aumlr Nordlund
- Chemistry, Medicine
- Nature
- 9 December 1993
The 2.2 & Aring; crystal structure of the 251K α2β2γ2 dimeric hydroxylase protein of methane mono-oxygenase from Methylococcus capsulatus (Bath) reveals the geometry of the catalytic di-iron… Expand
Chemical Characterization of the Smallest S-Nitrosothiol, HSNO; Cellular Cross-talk of H2S and S-Nitrosothiols
- M. Filipovic, J. Miljkovic, +6 authors I. Ivanović-Burmazović
- Chemistry, Medicine
- Journal of the American Chemical Society
- 28 June 2012
Dihydrogen sulfide recently emerged as a biological signaling molecule with important physiological roles and significant pharmacological potential. Chemically plausible explanations for its… Expand
Crystal structure of double-stranded DNA containing the major adduct of the anticancer drug cisplatin
- P. Takahara, A. Rosenzweig, C. A. Frederick, S. Lippard
- Chemistry, Medicine
- Nature
- 19 October 1995
THE success of cisplatin in cancer chemotherapy derives from its ability to crosslink DNA and alter the structure. Most cisplatiná¤-DNA adducts are intrastrand d(GpG) and d(ApG) crosslinks1, which… Expand
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