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Radiosensitizing Effect of YM155, a Novel Small-Molecule Survivin Suppressant, in Non–Small Cell Lung Cancer Cell Lines
The results suggest that YM155 sensitizes NSCLC cells to radiation both in vitro and in vivo, and that this effect is likely attributable, at least in part, to the inhibition of DNA repair and enhancement of apoptosis that result from the down-regulation of survivin expression. Expand
DNA Damage Induced by Alkylating Agents and Repair Pathways
The cytotoxic effects of alkylating agents are strongly attenuated by cellular DNA repair processes, necessitating a clear understanding of the repair mechanisms, and a detailed understanding of how cells cope with DNA damage caused by alkyLating agents is potentially useful in clinical medicine. Expand
Fluorine-18-labeled fluoroboronophenylalanine PET in patients with glioma.
The results of dynamic PET analysis suggested that K1 (measuring amino acid transport process) is a major factor determining the accumulation of 18F-10B-FBPA, and a comparison of the rate constants revealed that k3 did not correlate with the degree of malignancy. Expand
Recent advances in the biology of heavy-ion cancer therapy.
This paper briefly reviews the current knowledge of the biological aspects of heavy-ion therapy, and focuses on the authors' recent findings on repair mechanisms of heavy ion-induced DNA damage. Expand
Analysis of Common Deletion (CD) and a novel deletion of mitochondrial DNA induced by ionizing radiation
CD is induced by ionizing radiation, however, the amount of CD detected at a certain point in time after radiation exposure is dependent on the initial frequency of CD induced and the death rate of cells with mtDNA containing CD. Expand
Positron emission tomography-based boron neutron capture therapy using boronophenylalanine for high-grade gliomas: part I.
A new method based solely on PET based on positron emission tomography with fluorine-18-labeled L-fluoroborono-phenylalanine (L-18F-10B-FBPA) can potentially provide data that would assist in the selection of patients for future treatment with boron neutron capture therapy after surgical resection of their brain tumors. Expand
Induction of DNA double-strand breaks and cellular migration through bystander effects in cells irradiated with the slit-type microplanar beam of the spring-8 synchrotron.
Bystander effects are produced by factors secreted as a result of slit-type microplanar X-ray beam irradiation, suggesting that DNA dsbs were induced in nonirradiated cells by soluble factors in the culture medium. Expand
Effectiveness of BNCT for recurrent head and neck malignancies.
  • I. Kato, K. Ono, +6 authors Y. Yura
  • Medicine
  • Applied radiation and isotopes : including data…
  • 1 November 2004
First in the world, six patients with a recurrent HNM who have been treated with BNCT are reported, indicating that BN CT represents a new and promising treatment approach even for a huge or far advanced HNM. Expand
Positron emission tomography-based boron neutron capture therapy using boronophenylalanine for high-grade gliomas: part II.
  • Y. Imahori, S. Ueda, +7 authors R. Fujii
  • Medicine, Materials Science
  • Clinical cancer research : an official journal of…
  • 1 August 1998
This method, using the appropriate rate constant, permits the determination of tumor 10B concentration and is widely suitable for clinical BNCT, because the averaged PET data are enough to use in future patients without individual PET study. Expand
Boron neutron capture therapy outcomes for advanced or recurrent head and neck cancer
This study confirmed the feasibility of the dose-estimation method and that controlled trials are warranted and that the dose constraint was set to deliver a dose <10–12 Gy-eq to the skin or oral mucosa. Expand