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H2AFX gene

Known as: H2A HISTONE FAMILY, MEMBER X, H2AX, H2AFX 
This gene is involved in histone and nucleosome organization and chromatin compaction regulation.
National Institutes of Health

Papers overview

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2009
2009
The H2AX core histone variant is phosphorylated in chromatin around DNA double strand breaks (DSBs) and functions through unknown… Expand
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Highly Cited
2007
Highly Cited
2007
DNA virus infection can elicit the DNA damage response in host cells, including ATM kinase activation and H2AX phosphorylation… Expand
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Highly Cited
2007
Highly Cited
2007
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract and are caused by… Expand
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Highly Cited
2006
Highly Cited
2006
Histone H2AX promotes DNA double-strand break (DSB) repair and immunoglobulin heavy chain (IgH) class switch recombination (CSR… Expand
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Highly Cited
2006
Highly Cited
2006
DNA double-strand breaks (DSBs) caused by cellular exposure to genotoxic agents or produced by inherent metabolic processes… Expand
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Highly Cited
2004
Highly Cited
2004
In mammalian spermatogenesis, the X and Y chromosomes are transcriptionally silenced during the pachytene stage of meiotic… Expand
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Highly Cited
2003
Highly Cited
2003
During meiotic prophase in male mammals, the X and Y chromosomes condense to form a macrochromatin body, termed the sex, or XY… Expand
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Highly Cited
2003
Highly Cited
2003
Changes in chromatin structure induced by posttranslational modifications of histones are important regulators of genomic… Expand
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Highly Cited
2002
Highly Cited
2002
Higher order chromatin structure presents a barrier to the recognition and repair of DNA damage. Double-strand breaks (DSBs… Expand
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Highly Cited
2002
Highly Cited
2002
In mammalian cells, DNA double-strand breaks (DSBs) cause rapid phosphorylation of the H2AX core histone variant (to form gamma… Expand
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