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V(D)J Recombination

Known as: V-D-J joining, V-D-J recombination, V(D)J Rearrangement 
Any process of gene rearrangement in which the original variable and joining region coding segments of the immunoglobulin and T cell receptor genes… 
National Institutes of Health

Related topics

Related topics

49 relations
Cell Differentiation processDCLRE1C geneDCLRE1C wt AlleleG22P1 wt Allele

Papers overview

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Highly Cited
2001
Highly Cited
2001
Intermediates in V(D)J recombination: A stable RAG1/2 complex sequesters cleaved RSS ends
Rearrangement of gene segments to generate antigen receptor coding regions depends on the RAG1/2 recombinase, which assembles a… 
Review
1997
Review
1997
IL-7 receptor and VDJ recombination: trophic versus mechanistic actions.
Highly Cited
1996
Highly Cited
1996
Regions of RAG1 protein critical for V(D)J recombination
The products of the recombination activating genes RAG1 and RAG2 are essential for activating V(D)J recombination, and thus are… 
1996
1996
In vitro V(D)J recombination: signal joint formation.
The first step of V(D)J recombination, specific cleavage at the recombination signal sequence (RSS), can be carried out by the… 
Highly Cited
1996
Highly Cited
1996
The 12/23 rule is enforced at the cleavage step of V(D)J recombination in vivo
Background: V(D)J recombination is initiated by the introduction of double‐stranded breaks (DSB) adjacent to recombination signal… 
Highly Cited
1993
Highly Cited
1993
Unequal signal and coding joint formation in human V(D)J recombination
Substrates for studying V(D)J recombination in human cells and two human pre-B-cell lines that have active V(D)J recombination… 
Highly Cited
1993
Highly Cited
1993
Extent to which homology can constrain coding exon junctional diversity in V(D)J recombination
AMONG site-directed DNA recombination systems, V(D)J recombination is noteworthy in that identical reactants yield different… 
Review
1992
Review
1992
Activities involved in V(D)J recombination.
The assembly of Immunoglobulin (Ig) and T cell receptor (TCR) variable region gene segments (V, D, J) is a complex reaction that… 
Highly Cited
1992
Highly Cited
1992
BCL2 oncogene translocation is mediated by a chi-like consensus
Examination of 64 translocations involving the major breakpoint region (mbr) of the BCL2 oncogene and the immunoglobulin heavy… 
Highly Cited
1987
Highly Cited
1987
T cell receptor β gene sequences in the circular DNA of thymocyte nuclei: Direct evidence for intramolecular DNA deletion in V-D-J joining
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