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Long noncoding RNA GAS5 suppresses the migration and invasion of hepatocellular carcinoma cells via miR-21
GAS5 acts as a tumor suppressor in HCCs through negative regulation of miR-21 and its targets and proteins about migration and invasion in cancer cells, which may be a target for treating HCC. Expand
Regulation of miRNA-21 by reactive oxygen species-activated ERK/NF-κB in arsenite-induced cell transformation.
The transformation of HELF cells induced by chronic exposure to arsenite is mediated by increased miR-21 expression, which, in turn, ismediated by reactive oxygen species activation of the ERK/NF-κB pathway. Expand
STAT3-regulated exosomal miR-21 promotes angiogenesis and is involved in neoplastic processes of transformed human bronchial epithelial cells.
Exosomal miR-21 in exosomes leads to STAT3 activation, which increases VEGF levels in recipient cells, a process involved in angiogenesis and malignant transformation of HBE cells, providing a new perspective for intervention strategies to prevent carcinogenesis of lung cancer. Expand
Arsenite evokes IL-6 secretion, autocrine regulation of STAT3 signaling, and miR-21 expression, processes involved in the EMT and malignant transformation of human bronchial epithelial cells.
- Fei Luo, Yuan Xu, +7 authors Qizhan Liu
- Biology, Medicine
- Toxicology and applied pharmacology
- 15 November 2013
IL-6, acting on STAT3 signaling, which up-regulates miR-21in an autocrine manner, contributes to the EMT induced by arsenite, defining a link from inflammation to EMT in the arsenite-induced malignant transformation of HBE cells. Expand
MicroRNA‐191, by promoting the EMT and increasing CSC‐like properties, is involved in neoplastic and metastatic properties of transformed human bronchial epithelial cells
Results demonstrate that miR‐191 modulates the EMT and the CSC‐like properties of transformed cells and indicate that it is an onco‐miR involved in the neoplastic and metastatic properties of transformation cells. Expand
Delayed activation of extracellular-signal-regulated kinase 1/2 is involved in genistein- and equol-induced cell proliferation and estrogen-receptor-alpha-mediated transcription in MCF-7 breast…
- Huaqing Liu, Juan Du, +5 authors Z. Li
- Biology, Medicine
- The Journal of nutritional biochemistry
- 1 May 2010
Genistein and equol elicit a delayed activation of ERK1/2, and this activation appears to be involved in the proliferation of breast cancer cells and estrogen-dependent transcriptional activation. Expand
Polymorphisms in XRCC5, XRCC6, XRCC7 genes are involved in DNA double-strand breaks（DSBs） repair associated with the risk of acute myeloid leukemia（AML） in Chinese population
The XRCC6 −61C > G andXRCC5 2R/1R/0R polymorphisms, but not XR CC7 6721G > T polymorphism, could play an important role in the development of AML. Expand
Epithelial-mesenchymal transition and cancer stem cells, mediated by a long non-coding RNA, HOTAIR, are involved in cell malignant transformation induced by cigarette smoke extract.
A link between inflammation and EMT, processes involved in the malignant transformation of cells caused by CSE, is established, mediated through lncRNAs, establishes a mechanism for CSE-induced lung carcinogenesis. Expand
A MALAT1/HIF-2α feedback loop contributes to arsenite carcinogenesis
The results not only confirm a novel mechanism involving reciprocal regulation between MALAT1 and HIF-2α, but also expand the understanding of the carcinogenic potential of arsenite. Expand
Exosomal circRNA_100284 from arsenite-transformed cells, via microRNA-217 regulation of EZH2, is involved in the malignant transformation of human hepatic cells by accelerating the cell cycle and…
The results showed that circRNA_100284 is involved in the malignant transformation of L-02 cells induced by arsenite, and the concept that exosomal circRNAs are involved in cell–cell communication during carcinogenesis induced by arsenalite is supported. Expand