Triple-Negative Breast Cancer: Clinical Features and Patterns of Recurrence
- R. Dent, M. Trudeau, S. Narod
- MedicineClinical Cancer Research
- 1 August 2007
Triple-negative breast cancers have a more aggressive clinical course than other forms of breast cancer, but the adverse effect is transient.
Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies.
- A. Antoniou, P. Pharoah, D. Easton
- BiologyAmerican Journal of Human Genetics
- 1 May 2003
Risks in carriers were higher when based on index breast cancer cases diagnosed at <35 years of age and for variation in risk by mutation position for both genes, and some evidence for a reduction in risk in women from earlier birth cohorts is found.
Identification of the breast cancer susceptibility gene BRCA2
- R. Wooster, G. Bignell, M. Stratton
- MedicineNature
- 1 February 1996
Identification of the breast cancer susceptibility gene BRCA2
- R. Wooster, G. Bignell, M. Stratton
- BiologyNature
- 21 December 1995
The identification of a gene in which six different germline mutations in breast cancer families that are likely to be due to BRCA2 are detected, and results indicate that this is the BRC a2 gene.
Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium.
- D. Ford, D. Easton, M. Zelada-Hedman
- Medicine, BiologyAmerican Journal of Human Genetics
- 1 March 1998
The lifetime risk of breast cancer appears similar to the risk in BRCA1 carriers, but there was some suggestion of a lower risk in bRCA2 carriers <50 years of age.
Prevalence and penetrance of germline BRCA1 and BRCA2 mutations in a population series of 649 women with ovarian cancer.
- H. Risch, J. McLaughlin, S. Narod
- Biology, MedicineAmerican Journal of Human Genetics
- 1 March 2001
Risks of ovarian, breast, and stomach cancers and leukemias/lymphomas were increased nine-, five-, six- and threefold, respectively, among first-degree relatives of cases carrying BRCA1 mutations, compared with relatives of noncarriers, and risk of colorectal cancer was increased threefold for relatives of Cases carrying B RCA2 mutations.
Surveillance of BRCA1 and BRCA2 mutation carriers with magnetic resonance imaging, ultrasound, mammography, and clinical breast examination
CONTEXT
Current recommendations for women who have a BRCA1 or BRCA2 mutation are to undergo breast surveillance from age 25 years onward with mammography annually and clinical breast examination…
BRCA1 testing in families with hereditary breast-ovarian cancer. A prospective study of patient decision making and outcomes.
Only a subset of HBOC family members are likely to request BRCA1 testing when available and rates of test use may be higher in persons of a higher socioeconomic status and those with more relatives affected with breast cancer.
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25
- R. Hung, J. McKay, P. Brennan
- Biology, MedicineNature
- 3 April 2008
The results provide compelling evidence of a locus at 15q25 predisposing to lung cancer, and reinforce interest in nicotinic acetylcholine receptors as potential disease candidates and chemopreventative targets.
Low-penetrance susceptibility to breast cancer due to CHEK2*1100delC in noncarriers of BRCA1 or BRCA2 mutations
- H. Meijers-Heijboer, A. V. D. van den Ouweland, M. Stratton
- BiologyNature Genetics
- 22 April 2002
The biological mechanisms underlying the elevated risk of breast cancer in CHEK2 mutation carriers are already subverted in carriers of BRCA1 or BRCa2 mutations, which is consistent with participation of the encoded proteins in the same pathway.
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