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Regulation of homologous recombination by RNF20-dependent H2B ubiquitination.
The E3 ubiquitin ligase RNF20 regulates chromatin structure by monoubiquitinating histone H2B in transcription. Here, we show that RNF20 is localized to double-stranded DNA breaks (DSBs)… Expand
NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain.
DNA double-strand breaks represent the most potentially serious damage to a genome; hence, many repair proteins are recruited to nuclear damage sites by as yet poorly characterized sensor mechanisms.… Expand
Linkage between Werner Syndrome Protein and the Mre11 Complex via Nbs1*
- Wen-Hsing Cheng, C. von Kobbe, +5 authors V. Bohr
- Biology, Medicine
- Journal of Biological Chemistry
- 14 May 2004
The Werner syndrome and the Nijmegen breakage syndrome are recessive genetic disorders that show increased genomic instability, cancer predisposition, hypersensitivity to mitomycin C and… Expand
NBS1 Localizes to γ-H2AX Foci through Interaction with the FHA/BRCT Domain
Abstract DNA double-strand breaks represent the most potentially serious damage to a genome; hence, many repair proteins are recruited to nuclear damage sites by as yet poorly characterized sensor… Expand
Accumulation of Werner protein at DNA double-strand breaks in human cells
Werner syndrome is an autosomal recessive accelerated-aging disorder caused by a defect in the WRN gene, which encodes a member of the RecQ family of DNA helicases with an exonuclease activity. In… Expand
Monoallelic BUB1B mutations and defective mitotic‐spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome
- S. Matsuura, Y. Matsumoto, +14 authors T. Kajii
- Medicine, Biology
- American journal of medical genetics. Part A
- 15 February 2006
Cancer‐prone syndrome of premature chromatid separation (PCS syndrome) with mosaic variegated aneuploidy (MVA) is a rare autosomal recessive disorder characterized by growth retardation,… Expand
TopBP1 associates with NBS1 and is involved in homologous recombination repair.
- K. Morishima, Shuichi Sakamoto, +7 authors S. Matsuura
- Biology, Medicine
- Biochemical and biophysical research…
- 3 November 2007
TopBP1 is involved in DNA replication and DNA damage checkpoint. Recent studies have demonstrated that TopBP1 is a direct positive effecter of ATR. However, it is not known how TopBP1 recognizes… Expand
Acquired radioresistance of human tumor cells by DNA-PK/AKT/GSK3β-mediated cyclin D1 overexpression
Recurrence is frequently associated with the acquisition of radioresistance by tumors and resulting failures in radiotherapy. We report, in this study, that long-term fractionated radiation (FR)… Expand
Ataxia‐telangiectasia‐mutated dependent phosphorylation of Artemis in response to DNA damage
Artemis plays a crucial role in the hairpin‐opening step of antigen receptor VDJ gene recombination in the presence of catalytic subunit of deoxyribonucleic acid (DNA)‐dependent protein kinase… Expand
The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50[middle dot]hMRE11[middle dot]NBS1 complex DNA repair activity.
NBS1 (p95), the protein responsible for Nijmegen breakage syndrome, shows a weak homology to the yeast Xrs2 protein at the N terminus region, known as the forkhead-associated (FHA) domain and the… Expand