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Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice.
TLDR
Evidence is provided for a close interaction between IR, T cells, and the PD-L1/PD-1 axis and a basis for the rational design of combination therapy with immune modulators and radiotherapy is established. Expand
Integrative and Comparative Genomic Analysis of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas
TLDR
The mutational makeup of HPV-positive and HPV-negative HNSCC differs significantly, including targetable genes, includingtargetable genomic alterations in FGFR1, DDR2, EGFR, FGFR2/3, EPHA2, and PIK3CA. Expand
Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment.
TLDR
It is reported that reduction of tumor burden after ablative RT depends largely on T-cell responses, and the need for new strategies that not only reduce tumor burden but also enhance the role of antitumor immunity is emphasized. Expand
The Breast Cancer Susceptibility Gene BRCA1 Is Required for Subnuclear Assembly of Rad51 and Survival following Treatment with the DNA Cross-linking Agent Cisplatin*
TLDR
The studies suggest that Brca1 contributes to damage repair and/or tolerance by promoting assembly of Rad51, and this function appears to be shared with Brca2. Expand
STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors.
TLDR
Radiation-mediated antitumor immunity in immunogenic tumors requires a functional cytosolic DNA-sensing pathway and suggests that cGAMP treatment might provide a new strategy to improve radiotherapy. Expand
p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage
TLDR
It is shown that c-Abl binds to p73 in cells, interacting through its SH3 domain with the carboxy-terminal homo-oligomerization domain of p73, and that p73 participates in the apoptotic response to DNA damage. Expand
Accurate Three‐Dimensional Registration of CT, PET, and/or MR Images of the Brain
TLDR
A surface matching technique has been developed to register multiple imaging scans of the brain in three dimensions, with accuracy on the order of the image pixel sizes, which provides a novel quantitative method to address the fundamental problem of relating structure to function in the brain. Expand
Proteolytic activation of protein kinase C delta by an ICE‐like protease in apoptotic cells.
TLDR
These studies demonstrate that treatment of human U‐937 cells with ionizing radiation (IR) is associated with activation of a cytoplasmic myelin basic protein (MBP) kinase, and proves the induction of protein kinase C (PKC)‐like activity. Expand
Oligometastases revisited
TLDR
Clinical and laboratory data are reviewed that support the hypothesis that oligometastasis is a distinct clinical entity and that local cancer treatments are curative in a proportion of patients with metastases. Expand
Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation.
TLDR
It is reported that VEGF expression is induced in Lewis lung carcinomas (LLCs) both in vitro and vivo after exposure to ionizing radiation (IR) and in human tumor cell lines (Seg-1 esophageal adenocarcinoma, SQ20B squamous cell carcinoma, T98 and U87 glioblastomas, and U1 melanoma) in vitro. Expand
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