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GRM1 gene

Known as: GRM1-ALPHA, MGLUR1, GLUTAMATE RECEPTOR, METABOTROPIC, 1 
This gene plays a role in G protein-coupled receptor signal transduction and in neurotransmitter activity.
National Institutes of Health

Related topics

Related topics

9 relations
G Protein-Coupled Receptor SignalingLigand BindingMetabotropic Glutamate Receptor 1, humanReceptor Signaling

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GRM1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Novel Scaffold Identification of mGlu1 Receptor Negative Allosteric Modulators Using a Hierarchical Virtual Screening Approach
Metabotropic glutamate receptor 1 (mGluR1) is considered as an attractive drug target for neuropathic pain treatments. The… 
Review
2015
Review
2015
Group I and group II metabotropic glutamate receptor allosteric modulators as novel potential antipsychotics.
2012
2012
Polymorphisms within the metabotropic glutamate receptor 1 gene are associated with depression phenotypes
2011
2011
A phase II trial of riluzole, an antagonist of metabotropic glutamate receptor (GRM1) signaling, in advanced melanoma.
8557 Background: Preclinical studies demonstrate that GRM1 is a potential therapeutic target in melanoma, with > 60% of human… 
2010
2010
The metabotropic glutamate receptor 1, GRM1: evaluation as a candidate gene for inherited forms of cerebellar ataxia
The metabotropic glutamate (mGlu) 1 receptor, coded by the GRM1 gene, is involved in synaptic activities, learning and… 
2010
2010
Glutamatergic gene variants impact the clinical profile of efficacy and side effects of haloperidol
Background The glutamatergic system may be relevant to the pathophysiology of psychosis and to the effects of antipsychotic… 
2007
2007
Genetic analysis of the GRM1 gene in human melanoma susceptibility
Data obtained from a mouse model indicated that the ectopic expression of the Grm1 gene is sufficient for transforming… 
2005
2005
Interactions between Ephrin-B and Metabotropic Glutamate 1 Receptors in Brain Tissue and Cultured Neurons
We examined the interaction between ephrins and metabotropic glutamate (mGlu) receptors in the developing brain and cultured… 
2001
2001
Immunocytochemical localization of metabotropic glutamate receptor type 1α and tubulin in rat brain
The distribution of mGlu1α receptor and tubulin was immunocytochemically examined in the rat cerebellar cortex and primary rat… 
1998
1998
Functional coupling of human metabotropic glutamate receptor hmGlu1d: comparison to splice variants hmGlu1a and -1b
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