Skip to search form
Skip to main content
Skip to account menu
Semantic Scholar
Semantic Scholar's Logo
Search 209,893,512 papers from all fields of science
Search
Sign In
Create Free Account
GRM1 gene
Known as:
GRM1-ALPHA
, MGLUR1
, GLUTAMATE RECEPTOR, METABOTROPIC, 1
Expand
This gene plays a role in G protein-coupled receptor signal transduction and in neurotransmitter activity.
National Institutes of Health
Create Alert
Alert
Related topics
Related topics
9 relations
G Protein-Coupled Receptor Signaling
Ligand Binding
Metabotropic Glutamate Receptor 1, human
Receptor Signaling
Expand
Narrower (1)
GRM1 wt Allele
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator
Huixian Wu
,
Chong Wang
,
+9 authors
R. Stevens
Science
2014
Corpus ID: 206554335
Completing the Set G protein–coupled receptors (GPCRs) are membrane proteins that transduce extracellular signals to activate…
Expand
Highly Cited
2014
Highly Cited
2014
GRM1 is upregulated through gene fusion and promoter swapping in chondromyxoid fibroma
K. H. Nord
,
H. Lilljebjörn
,
+7 authors
K. Szuhai
Nature Genetics
2014
Corpus ID: 20990305
Glutamate receptors are well-known actors in the central and peripheral nervous systems, and altered glutamate signaling is…
Expand
Highly Cited
2012
Highly Cited
2012
Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder
J. Elia
,
J. Glessner
,
+61 authors
H. Hakonarson
Nature Genetics
2012
Corpus ID: 12023333
Attention deficit hyperactivity disorder (ADHD) is a common, heritable neuropsychiatric disorder of unknown etiology. We…
Expand
Highly Cited
2012
Highly Cited
2012
Autosomal-recessive congenital cerebellar ataxia is caused by mutations in metabotropic glutamate receptor 1.
V. Guergueltcheva
,
D. Azmanov
,
+15 authors
L. Kalaydjieva
American Journal of Human Genetics
2012
Corpus ID: 30502143
Highly Cited
2009
Highly Cited
2009
A Phase 0 Trial of Riluzole in Patients with Resectable Stage III and IV Melanoma
D. Yip
,
M. Le
,
+7 authors
James S Goydos
Clinical Cancer Research
2009
Corpus ID: 36635348
Purpose: Ectopic expression of GRM1 in murine melanocytes results in transformation into a form of melanoma, and more than 60% of…
Expand
Review
2008
Review
2008
Metabotropic Glutamate 1 Receptor: Current Concepts and Perspectives
F. Ferraguti
,
L. Crepaldi
,
F. Nicoletti
Pharmacological Reviews
2008
Corpus ID: 3149269
Almost 25 years after the first report that glutamate can activate receptors coupled to heterotrimeric G-proteins, tremendous…
Expand
Highly Cited
2004
Highly Cited
2004
Closed state of both binding domains of homodimeric mGlu receptors is required for full activity
J. Kniazeff
,
A. Bessis
,
D. Maurel
,
H. Ansanay
,
L. Prézeau
,
J. Pin
Nature Structural &Molecular Biology
2004
Corpus ID: 34185200
Membrane receptors, key components in signal transduction, often function as dimers. These include some G protein–coupled…
Expand
Highly Cited
2003
Highly Cited
2003
Mutational Analysis and Molecular Modeling of the Allosteric Binding Site of a Novel, Selective, Noncompetitive Antagonist of the Metabotropic Glutamate 1 Receptor*
P. Malherbe
,
N. Kratochwil
,
+6 authors
V. Mutel
Journal of Biological Chemistry
2003
Corpus ID: 24034398
A model of the rmGlu1 seven-transmembrane domain complexed with a negative allosteric modulator, 1-ethyl-2-methyl-6-oxo-4-(1,2,4…
Expand
Highly Cited
2003
Highly Cited
2003
[3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists.
H. Lavreysen
,
C. Janssen
,
F. Bischoff
,
X. Langlois
,
J. Leysen
,
A. Lesage
Molecular Pharmacology
2003
Corpus ID: 20269581
R214127 was shown to be a potent and noncompetitive metabotropic glutamate 1 (mGlu1) receptor-selective antagonist. The kinetics…
Expand
Highly Cited
2001
Highly Cited
2001
Positive allosteric modulators of metabotropic glutamate 1 receptor: Characterization, mechanism of action, and binding site
F. Knoflach
,
V. Mutel
,
+5 authors
J. Kemp
Proceedings of the National Academy of Sciences…
2001
Corpus ID: 3048531
We have identified two chemical series of compounds acting as selective positive allosteric modulators (enhancers) of native and…
Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our
Privacy Policy
(opens in a new tab)
,
Terms of Service
(opens in a new tab)
, and
Dataset License
(opens in a new tab)
ACCEPT & CONTINUE