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GRM1 gene

Known as: GRM1-ALPHA, MGLUR1, GLUTAMATE RECEPTOR, METABOTROPIC, 1 
This gene plays a role in G protein-coupled receptor signal transduction and in neurotransmitter activity.
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
Completing the Set G protein–coupled receptors (GPCRs) are membrane proteins that transduce extracellular signals to activate… 
Highly Cited
2014
Highly Cited
2014
Glutamate receptors are well-known actors in the central and peripheral nervous systems, and altered glutamate signaling is… 
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Highly Cited
2012
Highly Cited
2012
Attention deficit hyperactivity disorder (ADHD) is a common, heritable neuropsychiatric disorder of unknown etiology. We… 
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Highly Cited
2009
Highly Cited
2009
Purpose: Ectopic expression of GRM1 in murine melanocytes results in transformation into a form of melanoma, and more than 60% of… 
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Review
2008
Review
2008
Almost 25 years after the first report that glutamate can activate receptors coupled to heterotrimeric G-proteins, tremendous… 
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Highly Cited
2004
Highly Cited
2004
Membrane receptors, key components in signal transduction, often function as dimers. These include some G protein–coupled… 
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Highly Cited
2003
Highly Cited
2003
A model of the rmGlu1 seven-transmembrane domain complexed with a negative allosteric modulator, 1-ethyl-2-methyl-6-oxo-4-(1,2,4… 
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Highly Cited
2003
Highly Cited
2003
R214127 was shown to be a potent and noncompetitive metabotropic glutamate 1 (mGlu1) receptor-selective antagonist. The kinetics… 
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Highly Cited
2001
Highly Cited
2001
We have identified two chemical series of compounds acting as selective positive allosteric modulators (enhancers) of native and… 
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Highly Cited
1996
Highly Cited
1996
Numerous mAbs have been generated against Fc gamma RIII (CD16), the low-affinity receptor for the Fc part of IgG. Most of the…