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GRM1 gene

Known as: GRM1-ALPHA, MGLUR1, GLUTAMATE RECEPTOR, METABOTROPIC, 1 
This gene plays a role in G protein-coupled receptor signal transduction and in neurotransmitter activity.
National Institutes of Health

Related topics

Related topics

9 relations
G Protein-Coupled Receptor SignalingLigand BindingMetabotropic Glutamate Receptor 1, humanReceptor Signaling

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GRM1 wt Allele

Papers overview

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Highly Cited
2014
Highly Cited
2014
Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator
Completing the Set G protein–coupled receptors (GPCRs) are membrane proteins that transduce extracellular signals to activate… 
Highly Cited
2014
Highly Cited
2014
GRM1 is upregulated through gene fusion and promoter swapping in chondromyxoid fibroma
Glutamate receptors are well-known actors in the central and peripheral nervous systems, and altered glutamate signaling is… 
Highly Cited
2012
Highly Cited
2012
Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder (ADHD) is a common, heritable neuropsychiatric disorder of unknown etiology. We… 
Highly Cited
2012
Highly Cited
2012
Autosomal-recessive congenital cerebellar ataxia is caused by mutations in metabotropic glutamate receptor 1.
Highly Cited
2009
Highly Cited
2009
A Phase 0 Trial of Riluzole in Patients with Resectable Stage III and IV Melanoma
Purpose: Ectopic expression of GRM1 in murine melanocytes results in transformation into a form of melanoma, and more than 60% of… 
Review
2008
Review
2008
Metabotropic Glutamate 1 Receptor: Current Concepts and Perspectives
Almost 25 years after the first report that glutamate can activate receptors coupled to heterotrimeric G-proteins, tremendous… 
Highly Cited
2004
Highly Cited
2004
Closed state of both binding domains of homodimeric mGlu receptors is required for full activity
Membrane receptors, key components in signal transduction, often function as dimers. These include some G protein–coupled… 
Highly Cited
2003
Highly Cited
2003
Mutational Analysis and Molecular Modeling of the Allosteric Binding Site of a Novel, Selective, Noncompetitive Antagonist of the Metabotropic Glutamate 1 Receptor*
A model of the rmGlu1 seven-transmembrane domain complexed with a negative allosteric modulator, 1-ethyl-2-methyl-6-oxo-4-(1,2,4… 
Highly Cited
2003
Highly Cited
2003
[3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists.
R214127 was shown to be a potent and noncompetitive metabotropic glutamate 1 (mGlu1) receptor-selective antagonist. The kinetics… 
Highly Cited
2001
Highly Cited
2001
Positive allosteric modulators of metabotropic glutamate 1 receptor: Characterization, mechanism of action, and binding site
We have identified two chemical series of compounds acting as selective positive allosteric modulators (enhancers) of native and… 
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