GRM1 gene

Known as: GRM1-ALPHA, MGLUR1, GLUTAMATE RECEPTOR, METABOTROPIC, 1 
This gene plays a role in G protein-coupled receptor signal transduction and in neurotransmitter activity.
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
The excitatory neurotransmitter glutamate induces modulatory actions via the metabotropic glutamate receptors (mGlus), which are… (More)
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2012
2012
We analysed a phenotypically well-characterised sample of 450 schziophrenia patients and 605 controls for rare non-synonymous… (More)
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Highly Cited
2011
Highly Cited
2011
Attention deficit hyperactivity disorder (ADHD) is a common, heritable neuropsychiatric disorder of unknown etiology. We… (More)
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2008
2008
Previously, we reported a transgenic mouse line, TG-3, that develops spontaneous melanoma with 100% penetrance. We demonstrated… (More)
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Highly Cited
2004
Highly Cited
2004
Membrane receptors, key components in signal transduction, often function as dimers. These include some G protein–coupled… (More)
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Highly Cited
2003
Highly Cited
2003
A model of the rmGlu1 seven-transmembrane domain complexed with a negative allosteric modulator, 1-ethyl-2-methyl-6-oxo-4-(1,2,4… (More)
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2003
2003
N-Methyl-d-aspartate (NMDA) receptors play key roles in both physiological processes, particularly synaptic plasticity, and in… (More)
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2003
2003
R214127 was shown to be a potent and noncompetitive metabotropic glutamate 1 (mGlu1) receptor-selective antagonist. The kinetics… (More)
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Highly Cited
2001
Highly Cited
2001
We have identified two chemical series of compounds acting as selective positive allosteric modulators (enhancers) of native and… (More)
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