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GRM1 gene

Known as: GRM1-ALPHA, MGLUR1, GLUTAMATE RECEPTOR, METABOTROPIC, 1 
This gene plays a role in G protein-coupled receptor signal transduction and in neurotransmitter activity.
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
Completing the Set G protein–coupled receptors (GPCRs) are membrane proteins that transduce extracellular signals to activate… Expand
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2014
2014
Mesial temporal lobe epilepsy (MTLE) is one of the most common types of the intractable epilepsies and is most often associated… Expand
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Highly Cited
2009
Highly Cited
2009
Purpose: Ectopic expression of GRM1 in murine melanocytes results in transformation into a form of melanoma, and more than 60% of… Expand
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Highly Cited
2008
Highly Cited
2008
Previously, we reported a transgenic mouse line, TG‐3, that develops spontaneous melanoma with 100% penetrance. We demonstrated… Expand
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Highly Cited
2004
Highly Cited
2004
Membrane receptors, key components in signal transduction, often function as dimers. These include some G protein–coupled… Expand
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Highly Cited
2003
Highly Cited
2003
A model of the rmGlu1 seven-transmembrane domain complexed with a negative allosteric modulator, 1-ethyl-2-methyl-6-oxo-4-(1,2,4… Expand
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Highly Cited
2003
Highly Cited
2003
R214127 was shown to be a potent and noncompetitive metabotropic glutamate 1 (mGlu1) receptor-selective antagonist. The kinetics… Expand
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Highly Cited
2003
Highly Cited
2003
N-Methyl-d-aspartate (NMDA) receptors play key roles in both physiological processes, particularly synaptic plasticity, and in… Expand
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Highly Cited
2001
Highly Cited
2001
We have identified two chemical series of compounds acting as selective positive allosteric modulators (enhancers) of native and… Expand
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Highly Cited
1996
Highly Cited
1996
Numerous mAbs have been generated against Fc gamma RIII (CD16), the low-affinity receptor for the Fc part of IgG. Most of the… Expand
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