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GRM1 gene

Known as: GRM1-ALPHA, MGLUR1, GLUTAMATE RECEPTOR, METABOTROPIC, 1 
This gene plays a role in G protein-coupled receptor signal transduction and in neurotransmitter activity.
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
Accumulating data indicate that the glutamate system is disrupted in major depressive disorder (MDD), and recent clinical… 
Highly Cited
2014
Highly Cited
2014
Completing the Set G protein–coupled receptors (GPCRs) are membrane proteins that transduce extracellular signals to activate… 
Highly Cited
2014
Highly Cited
2014
Glutamate receptors are well-known actors in the central and peripheral nervous systems, and altered glutamate signaling is… 
Highly Cited
2012
Highly Cited
2012
We analysed a phenotypically well-characterised sample of 450 schziophrenia patients and 605 controls for rare non-synonymous… 
Highly Cited
2011
Highly Cited
2011
Attention deficit hyperactivity disorder (ADHD) is a common, heritable neuropsychiatric disorder of unknown etiology. We… 
Review
2008
Review
2008
Almost 25 years after the first report that glutamate can activate receptors coupled to heterotrimeric G-proteins, tremendous… 
Highly Cited
2004
Highly Cited
2004
Membrane receptors, key components in signal transduction, often function as dimers. These include some G protein–coupled… 
Highly Cited
2003
Highly Cited
2003
A model of the rmGlu1 seven-transmembrane domain complexed with a negative allosteric modulator, 1-ethyl-2-methyl-6-oxo-4-(1,2,4… 
Highly Cited
2003
Highly Cited
2003
R214127 was shown to be a potent and noncompetitive metabotropic glutamate 1 (mGlu1) receptor-selective antagonist. The kinetics… 
Highly Cited
2000
Highly Cited
2000
Western blot analysis of protein extracts from rat liver revealed the presence of the mGlu5 receptor, one of the G‐protein…