GRM1 gene

Completing the Set G protein–coupled receptors (GPCRs) are membrane proteins that transduce extracellular signals to activate… Expand

Mesial temporal lobe epilepsy (MTLE) is one of the most common types of the intractable epilepsies and is most often associated… Expand

Purpose: Ectopic expression of GRM1 in murine melanocytes results in transformation into a form of melanoma, and more than 60% of… Expand

Previously, we reported a transgenic mouse line, TG‐3, that develops spontaneous melanoma with 100% penetrance. We demonstrated… Expand

Membrane receptors, key components in signal transduction, often function as dimers. These include some G protein–coupled… Expand

A model of the rmGlu1 seven-transmembrane domain complexed with a negative allosteric modulator, 1-ethyl-2-methyl-6-oxo-4-(1,2,4… Expand

R214127 was shown to be a potent and noncompetitive metabotropic glutamate 1 (mGlu1) receptor-selective antagonist. The kinetics… Expand

N-Methyl-d-aspartate (NMDA) receptors play key roles in both physiological processes, particularly synaptic plasticity, and in… Expand

We have identified two chemical series of compounds acting as selective positive allosteric modulators (enhancers) of native and… Expand

Numerous mAbs have been generated against Fc gamma RIII (CD16), the low-affinity receptor for the Fc part of IgG. Most of the… Expand