GRM1 gene

Known as: GRM1-ALPHA, MGLUR1, GLUTAMATE RECEPTOR, METABOTROPIC, 1 
This gene plays a role in G protein-coupled receptor signal transduction and in neurotransmitter activity.
National Institutes of Health

Related topics

Related topics

9 relations
G Protein-Coupled Receptor SignalingLigand BindingMetabotropic Glutamate Receptor 1, humanReceptor Signaling
(More)

Narrower (1)

GRM1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Sex differences in glutamate receptor gene expression in major depression and suicide
 
Is this relevant?
Highly Cited
2014
Highly Cited
2014
Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator
The excitatory neurotransmitter glutamate induces modulatory actions via the metabotropic glutamate receptors (mGlus), which are… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2012
2012
Deleterious GRM1 Mutations in Schizophrenia
We analysed a phenotypically well-characterised sample of 450 schziophrenia patients and 605 controls for rare non-synonymous… (More)
  • figure 1
  • table 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2011
Highly Cited
2011
Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder (ADHD) is a common, heritable neuropsychiatric disorder of unknown etiology. We… (More)
Is this relevant?
2008
2008
Oncogenic activities of metabotropic glutamate receptor 1 (Grm1) in melanocyte transformation.
Previously, we reported a transgenic mouse line, TG-3, that develops spontaneous melanoma with 100% penetrance. We demonstrated… (More)
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Closed state of both binding domains of homodimeric mGlu receptors is required for full activity
Membrane receptors, key components in signal transduction, often function as dimers. These include some G protein–coupled… (More)
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Mutational analysis and molecular modeling of the allosteric binding site of a novel, selective, noncompetitive antagonist of the metabotropic glutamate 1 receptor.
A model of the rmGlu1 seven-transmembrane domain complexed with a negative allosteric modulator, 1-ethyl-2-methyl-6-oxo-4-(1,2,4… (More)
  • figure 1
  • table I
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2003
2003
Identification of critical residues in the amino terminal domain of the human NR2B subunit involved in the RO 25-6981 binding pocket.
N-Methyl-d-aspartate (NMDA) receptors play key roles in both physiological processes, particularly synaptic plasticity, and in… (More)
Is this relevant?
2003
2003
[3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists.
R214127 was shown to be a potent and noncompetitive metabotropic glutamate 1 (mGlu1) receptor-selective antagonist. The kinetics… (More)
  • figure 1
  • figure 2
  • figure 4
  • figure 5
  • figure 3
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site.
We have identified two chemical series of compounds acting as selective positive allosteric modulators (enhancers) of native and… (More)
  • figure 2
  • table 3
  • figure 1
  • figure 2
  • figure 3
Is this relevant?