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GRM1 gene

Known as: GRM1-ALPHA, MGLUR1, GLUTAMATE RECEPTOR, METABOTROPIC, 1 
This gene plays a role in G protein-coupled receptor signal transduction and in neurotransmitter activity.
National Institutes of Health

Related topics

Related topics

9 relations
G Protein-Coupled Receptor SignalingLigand BindingMetabotropic Glutamate Receptor 1, humanReceptor Signaling

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GRM1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Targeting mGlu Receptors for Optimization of Antipsychotic Activity and Disease-Modifying Effect in Schizophrenia
Metabotropic glutamate (mGlu) receptors are considered as candidate drug targets for the treatment of schizophrenia. These… 
2015
2015
Metabotropic glutamate receptor 1 disrupts mammary acinar architecture and initiates malignant transformation of mammary epithelial cells
Metabotropic glutamate receptor 1 (mGluR1/Grm1) is a member of the G-protein-coupled receptor superfamily, which was once thought… 
Review
2015
Review
2015
Group I and group II metabotropic glutamate receptor allosteric modulators as novel potential antipsychotics.
Highly Cited
2010
Highly Cited
2010
The glutamate release inhibitor Riluzole decreases migration, invasion, and proliferation of melanoma cells.
The goal of this study was to examine the effects of metabotropic glutamate receptor-1 (GRM1) blockade on melanoma anchorage… 
2010
2010
The Protective Signaling of Metabotropic Glutamate Receptor 1 Is Mediated by Sustained, β-Arrestin-1-dependent ERK Phosphorylation*
Metabotropic glutamate receptor 1 (mGlu1) is a G protein-coupled receptor that enhances the hydrolysis of membrane… 
2005
2005
Interactions between Ephrin-B and Metabotropic Glutamate 1 Receptors in Brain Tissue and Cultured Neurons
We examined the interaction between ephrins and metabotropic glutamate (mGlu) receptors in the developing brain and cultured… 
Highly Cited
2003
Highly Cited
2003
Mutational Analysis and Molecular Modeling of the Allosteric Binding Site of a Novel, Selective, Noncompetitive Antagonist of the Metabotropic Glutamate 1 Receptor*
A model of the rmGlu1 seven-transmembrane domain complexed with a negative allosteric modulator, 1-ethyl-2-methyl-6-oxo-4-(1,2,4… 
Highly Cited
2003
Highly Cited
2003
Identification of Critical Residues in the Amino Terminal Domain of the Human NR2B Subunit Involved in the RO 25-6981 Binding Pocket
N-Methyl-d-aspartate (NMDA) receptors play key roles in both physiological processes, particularly synaptic plasticity, and in… 
Highly Cited
2000
Highly Cited
2000
Selective blockade of mGlu5 metabotropic glutamate receptors protects rat hepatocytes against hypoxic damage
Western blot analysis of protein extracts from rat liver revealed the presence of the mGlu5 receptor, one of the G‐protein… 
Highly Cited
1996
Highly Cited
1996
The binding epitopes of human CD16 (Fc gamma RIII) monoclonal antibodies. Implications for ligand binding.
Numerous mAbs have been generated against Fc gamma RIII (CD16), the low-affinity receptor for the Fc part of IgG. Most of the… 
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