Genetic analysis of the GRM1 gene in human melanoma susceptibility

@article{Ortiz2007GeneticAO,
  title={Genetic analysis of the GRM1 gene in human melanoma susceptibility},
  author={Pablo A. Ortiz and Francisco Vanaclocha and Eduardo L{\'o}pez-Bran and J I Esquivias and Jose L Lopez-Estebaranz and Manuel Mart{\'i}n-Gonz{\'a}lez and Itz{\'i}ar Arrue and Diana Garc{\'i}a-Romero and Carolina L Ochoa and Antonio Gonz{\'a}lez-P{\'e}rez and Agustin Gutierrez Ruiz and Luis Miguel Real},
  journal={European Journal of Human Genetics},
  year={2007},
  volume={15},
  pages={1176-1182}
}
  • Pablo A. Ortiz, Francisco Vanaclocha, +9 authors Luis Miguel Real
  • Published in
    European Journal of Human…
    2007
  • Biology, Medicine
  • Data obtained from a mouse model indicated that the ectopic expression of the Grm1 gene is sufficient for transforming melanocytes and causing malignant melanoma in vivo. In addition, it has also been documented that the GRM1 gene is aberrantly expressed in human melanomas. Here we have performed a genetic association study to elucidate whether the GRM1 gene contributes to human melanoma susceptibility. To carry out this study, we initially genotyped 250 melanoma patients and 329 nonselected… CONTINUE READING

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