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Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia
This study provides compelling evidence for the importance of metabotropic glutamate signaling in melanocytic neoplasia and detects expression of GRM1 in a number of human melanoma biopsies and cell lines but not in benign nevi and melanocytes.
Metabotropic glutamate receptor 1 and glutamate signaling in human melanoma.
The importance of glutamate signaling in human melanoma is suggested and the suppression of glutamate signalling may be a new target for melanoma therapy.
Rewired ERK-JNK signaling pathways in melanoma.
Phase II Trial of 17-Allylamino-17-Demethoxygeldanamycin in Patients with Metastatic Melanoma
- D. Solit, I. Osman, +10 authors P. Chapman
- Biology, MedicineClinical Cancer Research
- 15 December 2008
The effects of 17-AAG on RAF kinase expression were short-lived, and no objective antimelanoma responses were seen, suggesting that future trials in melanoma should focus on a more potent hsp90 inhibitor or a formulation that can be administered chronically for a more prolonged suppression of the MAPK pathway.
Prospective multi-institutional study of reverse transcriptase polymerase chain reaction for molecular staging of melanoma.
- C. Scoggins, M. Ross, +15 authors K. McMasters
- MedicineJournal of clinical oncology : official journal…
- 20 June 2006
In this large, prospective, multi-institutional study, RT-PCR analysis on SLNs and PBMCs provides no additional prognostic information beyond standard histopathologic analysis of SLNs, and RT- PCI remains investigational and should not be used to direct adjuvant therapy at this time.
Lessons learned from the Sunbelt Melanoma Trial
A practical definition of sentinel nodes based on the degree of radioactivity is developed and the low rate of postoperative complications associated with SLN biopsy as compared to complete lymph node dissection is established, suggesting that completion lymphadenectomy is appropriate for such patients.
Factors Associated with False-Negative Sentinel Lymph Node Biopsy in Melanoma Patients
- C. Scoggins, Robert C. G. Martin, +12 authors K. McMasters
- MedicineAnnals of Surgical Oncology
- 1 March 2010
This is the largest study to evaluate false-negative sentinel lymph node results in melanoma, with a FN rate of 10.8%.
A phase I trial of a synthetic mucin peptide vaccine. Induction of specific immune reactivity in patients with adenocarcinoma.
- James S Goydos, E. Elder, T. Whiteside, O. Finn, M. Lotze
- MedicineThe Journal of surgical research
- 1 June 1996
Mucin vaccination is safe and might serve to enhance specific responses to tumor antigens and increasing serum levels of IL-6 correlated with constitutional symptoms and hypoalbuminemia but not with the extent of skin breakdown at vaccination sites.
Constitutive Smad linker phosphorylation in melanoma: a mechanism of resistance to transforming growth factor‐β‐mediated growth inhibition
- K. Cohen-Solal, Kim T. Merrigan, +6 authors M. Reiss
- Biology, MedicinePigment cell & melanoma research
- 1 June 2011
The results suggest that the linker phosphorylation of Smad3 contributes to the resistance of melanoma cells to TGFβ‐mediated growth inhibition.
Marked elevation of serum interleukin-6 in patients with cholangiocarcinoma: validation of utility as a clinical marker.
- James S Goydos, A. Brumfield, E. Frezza, A. Booth, M. Lotze, S. Carty
- MedicineAnnals of surgery
- 1 March 1998
In selected patients, a high serum level of IL-6 marks patients with cholangiocarcinoma and correlates with tumor burden both before and after resection.