Metabotropic Glutamate Receptor 1, human

Known as: MGLUR1-Alpha, GRM1-Alpha, Metabotropic Glutamate Receptor 1 
Metabotropic glutamate receptor 1 (1194 aa, ~132 kDa) is encoded by the human GRM1 gene. This protein plays a role in in G protein-coupled receptor… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1992-2018
010203019922018

Related topics

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14 relations
G Protein-Coupled Receptor GenesG Protein-Coupled Receptor SignalingGRM1 geneGRM1 wt Allele
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Broader (1)

metabotropic glutamate receptor type 1

Related mentions per year

Related mentions per year

1936-2019
19401960198020002020
Metabotropic Glutamate Receptor 1, human
Plasma membrane
Signal Transduction
Synaptic Transmission
Integral Membrane Proteins
Transmembrane Domain

Papers overview

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Highly Cited
2014
Highly Cited
2014
Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator
The excitatory neurotransmitter glutamate induces modulatory actions via the metabotropic glutamate receptors (mGlus), which are… (More)
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2012
2012
Autosomal-recessive congenital cerebellar ataxia is caused by mutations in metabotropic glutamate receptor 1.
Autosomal-recessive congenital cerebellar ataxia was identified in Roma patients originating from a small subisolate with a known… (More)
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2011
2011
Metabotropic glutamate receptor-1: a potential therapeutic target for the treatment of breast cancer
Metabotropic glutamate receptors are G-protein-coupled receptors normally expressed in the central nervous system where they… (More)
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2008
2008
Pharmacological effects of the metabotropic glutamate receptor 1 antagonist compared with those of the metabotropic glutamate receptor 5 antagonist and metabotropic glutamate receptor 2/3 agonist in…
The functional roles of metabotropic glutamate receptor (mGluR) 1 in integrative brain functions were investigated using a potent… (More)
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Highly Cited
2007
Highly Cited
2007
Metabotropic glutamate receptor 1 and glutamate signaling in human melanoma.
Recently, several laboratories have started to investigate the involvement of glutamate signaling in cancer. In previous studies… (More)
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Highly Cited
2003
Highly Cited
2003
Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia
To gain insight into melanoma pathogenesis, we characterized an insertional mouse mutant, TG3, that is predisposed to develop… (More)
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Highly Cited
2002
Highly Cited
2002
Metabotropic glutamate receptor 1-induced upregulation of NMDA receptor current: mediation through the Pyk2/Src-family kinase pathway in cortical neurons.
The mechanism underlying the upregulation of NMDA receptor function by group I metabotropic glutamate receptors (mGluRs… (More)
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Highly Cited
2002
Highly Cited
2002
Neutrophil-derived glutamate regulates vascular endothelial barrier function.
Endothelial barrier function is altered by the release of soluble polymorphonuclear leukocyte (PMN)-derived mediators during… (More)
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Highly Cited
1999
Highly Cited
1999
CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding.
Metabotropic glutamate receptors (mGluRs) are a family of G protein-coupled receptors characterized by a large, extracellular N… (More)
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Highly Cited
1994
Highly Cited
1994
Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice.
We generated a novel strain of mutant mouse with a deletion in the gene encoding metabotropic glutamate receptor 1 (mGluR1… (More)
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