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Ephrin Type-A Receptor 2, human

Known as: EC 2.7.1.112, Tyrosine-Protein Kinase Receptor ECK, Epithelial Cell Receptor Protein Tyrosine Kinase 
Ephrin type-A receptor 2 (976 aa, ~108 kDa) is encoded by the human EPHA2 gene. This protein plays a role in ephrin-A binding, cell-cell signaling… 
National Institutes of Health

Related topics

Related topics

29 relations
Axon GuidanceCell Differentiation processCell ProliferationEPHA2 gene

Broader (2)

EphB2 ReceptorProtein Tyrosine Kinase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Efficacy and antivascular effects of EphA2 reduction with an agonistic antibody in ovarian cancer.
BACKGROUND EphA2 is an oncoprotein and tyrosine kinase receptor that is overexpressed in ovarian and many other cancers. We… 
Highly Cited
2005
Highly Cited
2005
EphA2 as a glioma-associated antigen: a novel target for glioma vaccines.
EphA2 is a receptor tyrosine kinase and is frequently overexpressed in a wide array of advanced cancers. We demonstrate in the… 
Highly Cited
2004
Highly Cited
2004
EphA2: a determinant of malignant cellular behavior and a potential therapeutic target in pancreatic adenocarcinoma
The EphA2 receptor tyrosine kinase is overexpressed in a variety of human cancers. We sought to characterize the role of EphA2 in… 
Review
2004
Review
2004
Overexpression and functional alterations of the EphA2 tyrosine kinase in cancer
Cancer is a disease of aberrant signal transduction. The expression and function of intracellular signaling pathways are… 
Highly Cited
2003
Highly Cited
2003
Predictive value of the EphA2 receptor tyrosine kinase in lung cancer recurrence and survival.
PURPOSE Underestimation of disease severity is a major problem confronting the successful clinical management of non-small cell… 
Highly Cited
2003
Highly Cited
2003
High-level expression of EphA2 receptor tyrosine kinase in prostatic intraepithelial neoplasia.
Highly Cited
2001
Highly Cited
2001
EphA2 overexpression causes tumorigenesis of mammary epithelial cells.
Elevated levels of protein tyrosine phosphorylation contribute to a malignant phenotype, although the tyrosine kinases that are… 
Highly Cited
2001
Highly Cited
2001
Molecular regulation of tumor cell vasculogenic mimicry by tyrosine phosphorylation: role of epithelial cell kinase (Eck/EphA2).
During embryogenesis, blood vessels are formed initially by the process of vasculogenesis, the in situ differentiation of… 
Highly Cited
2001
Highly Cited
2001
Receptor tyrosine kinase EphA2 is regulated by p53-family proteins and induces apoptosis
The p53 tumor suppressor protein is mutated in more than 50% of all human cancers, which makes the study of its functions and… 
Highly Cited
1999
Highly Cited
1999
Overexpression of the EphA2 tyrosine kinase in prostate cancer
Molecules that are highly expressed by human prostate cancers may serve as therapeutically relevant targets or tumor markers… 
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