EphA2 overexpression causes tumorigenesis of mammary epithelial cells.

@article{Zelinski2001EphA2OC,
  title={EphA2 overexpression causes tumorigenesis of mammary epithelial cells.},
  author={Daniel Paul Zelinski and Nicole Dodge Zantek and Julianna Stewart and Armando R. Irizarry and Michael S. Kinch},
  journal={Cancer research},
  year={2001},
  volume={61 5},
  pages={
          2301-6
        }
}
Elevated levels of protein tyrosine phosphorylation contribute to a malignant phenotype, although the tyrosine kinases that are responsible for this signaling remain largely unknown. Here we report increased levels of the EphA2 (ECK) protein tyrosine kinase in clinical specimens and cell models of breast cancer. We also show that EphA2 overexpression is sufficient to confer malignant transformation and tumorigenic potential on nontransformed (MCF-10A) mammary epithelial cells. The transforming… CONTINUE READING

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EphA2 kinase associates with focal adhesion kinase and upon activation, inhibits integrin-mediated cell adhesion and migration

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