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EPHA2 gene

Known as: EPHRIN RECEPTOR EphA2, ECK, EPITHELIAL CELL RECEPTOR PROTEIN-TYROSINE KINASE 
This gene plays a role in development and is upregulated in several breast carcinomas.
National Institutes of Health

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EPHA2 wt Allele
Ephrin Type-A Receptor 2, humanLigand BindingPhosphorylationReceptor Signaling

Papers overview

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Highly Cited
2010
Highly Cited
2010
Elevation of receptor tyrosine kinase EphA2 mediates resistance to trastuzumab therapy.
One arising challenge in the treatment of breast cancer is the development of therapeutic resistance to trastuzumab, an antibody… 
Highly Cited
2008
Highly Cited
2008
The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling.
Overexpression of the receptor tyrosine kinase EPH receptor A2 (EphA2) is commonly observed in aggressive breast cancer and… 
Highly Cited
2005
Highly Cited
2005
A conditional feedback loop regulates Ras activity through EphA2.
Highly Cited
2004
Highly Cited
2004
EphA2: a determinant of malignant cellular behavior and a potential therapeutic target in pancreatic adenocarcinoma
The EphA2 receptor tyrosine kinase is overexpressed in a variety of human cancers. We sought to characterize the role of EphA2 in… 
Highly Cited
2003
Highly Cited
2003
Differential EphA2 epitope display on normal versus malignant cells.
The EphA2 receptor tyrosine kinase is overexpressed in many different types of human cancers where it functions as a powerful… 
Highly Cited
2001
Highly Cited
2001
EphA2 overexpression causes tumorigenesis of mammary epithelial cells.
Elevated levels of protein tyrosine phosphorylation contribute to a malignant phenotype, although the tyrosine kinases that are… 
Highly Cited
2001
Highly Cited
2001
Receptor tyrosine kinase EphA2 is regulated by p53-family proteins and induces apoptosis
The p53 tumor suppressor protein is mutated in more than 50% of all human cancers, which makes the study of its functions and… 
Highly Cited
1995
Highly Cited
1995
Protein B61 as a new growth factor: expression of B61 and up-regulation of its receptor epithelial cell kinase during melanoma progression.
Epithelial cell kinase (ECK) is a receptor protein tyrosine kinase, the role of which in melanoma biology is unclear. Here we… 
Highly Cited
1995
Highly Cited
1995
Abnormal protein tyrosine kinase gene expression during melanoma progression and metastasis
Protein tyrosine kinases have been implicated in tumor initiation and progression. Here we used Northern blotting to study… 
Highly Cited
1994
Highly Cited
1994
B61 is a ligand for the ECK receptor protein-tyrosine kinase
A PROTEIN ligand for the ECK1 receptor protein-tyrosine kinase has been isolated by using the extracellular domain (ECK-X) of the… 
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