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EPHA2 gene
Known as:
EPHRIN RECEPTOR EphA2
, ECK
, EPITHELIAL CELL RECEPTOR PROTEIN-TYROSINE KINASE
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This gene plays a role in development and is upregulated in several breast carcinomas.
National Institutes of Health
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Related topics
Related topics
6 relations
Narrower (1)
EPHA2 wt Allele
Ephrin Type-A Receptor 2, human
Ligand Binding
Phosphorylation
Receptor Signaling
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Elevation of receptor tyrosine kinase EphA2 mediates resistance to trastuzumab therapy.
G. Zhuang
,
D. Brantley-Sieders
,
+7 authors
Junya Chen
Cancer Research
2010
Corpus ID: 16209591
One arising challenge in the treatment of breast cancer is the development of therapeutic resistance to trastuzumab, an antibody…
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Highly Cited
2008
Highly Cited
2008
The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling.
D. Brantley-Sieders
,
G. Zhuang
,
+8 authors
Junya Chen
Journal of Clinical Investigation
2008
Corpus ID: 7492674
Overexpression of the receptor tyrosine kinase EPH receptor A2 (EphA2) is commonly observed in aggressive breast cancer and…
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Highly Cited
2005
Highly Cited
2005
A conditional feedback loop regulates Ras activity through EphA2.
Madhu Macrae
,
R. Neve
,
+5 authors
F. McCormick
Cancer Cell
2005
Corpus ID: 2434847
Highly Cited
2004
Highly Cited
2004
EphA2: a determinant of malignant cellular behavior and a potential therapeutic target in pancreatic adenocarcinoma
M. Duxbury
,
Hiromichi Ito
,
M. Zinner
,
S. Ashley
,
E. Whang
Oncogene
2004
Corpus ID: 2837703
The EphA2 receptor tyrosine kinase is overexpressed in a variety of human cancers. We sought to characterize the role of EphA2 in…
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Highly Cited
2003
Highly Cited
2003
Differential EphA2 epitope display on normal versus malignant cells.
K. Coffman
,
Min Hu
,
+8 authors
M. Kinch
Cancer Research
2003
Corpus ID: 17540862
The EphA2 receptor tyrosine kinase is overexpressed in many different types of human cancers where it functions as a powerful…
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Highly Cited
2001
Highly Cited
2001
EphA2 overexpression causes tumorigenesis of mammary epithelial cells.
D. P. Zelinski
,
N. Zantek
,
J. Stewart
,
A. Irizarry
,
M. Kinch
Cancer Research
2001
Corpus ID: 18504653
Elevated levels of protein tyrosine phosphorylation contribute to a malignant phenotype, although the tyrosine kinases that are…
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Highly Cited
2001
Highly Cited
2001
Receptor tyrosine kinase EphA2 is regulated by p53-family proteins and induces apoptosis
M. Dohn
,
Jieyuan Jiang
,
Xinbin Chen
Oncogene
2001
Corpus ID: 20052070
The p53 tumor suppressor protein is mutated in more than 50% of all human cancers, which makes the study of its functions and…
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Highly Cited
1995
Highly Cited
1995
Protein B61 as a new growth factor: expression of B61 and up-regulation of its receptor epithelial cell kinase during melanoma progression.
D. Easty
,
B. Guthrie
,
+5 authors
D. Bennett
Cancer Research
1995
Corpus ID: 34860987
Epithelial cell kinase (ECK) is a receptor protein tyrosine kinase, the role of which in melanoma biology is unclear. Here we…
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Highly Cited
1995
Highly Cited
1995
Abnormal protein tyrosine kinase gene expression during melanoma progression and metastasis
D. Easty
,
M. Herlyn
,
D. Bennett
International Journal of Cancer
1995
Corpus ID: 42843769
Protein tyrosine kinases have been implicated in tumor initiation and progression. Here we used Northern blotting to study…
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Highly Cited
1994
Highly Cited
1994
B61 is a ligand for the ECK receptor protein-tyrosine kinase
T. Bartley
,
R. Hunt
,
+17 authors
G. M. Fox
Nature
1994
Corpus ID: 4304538
A PROTEIN ligand for the ECK1 receptor protein-tyrosine kinase has been isolated by using the extracellular domain (ECK-X) of the…
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