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EphA2: a determinant of malignant cellular behavior and a potential therapeutic target in pancreatic adenocarcinoma
EphA1 siRNA suppresses EphA2 expression, cellular invasiveness, anoikis resistance and FAK phosphorylation in vitro and retards tumor growth and inhibits metastasis in vivo and is both a determinant of malignant cellular behavior and a potential therapeutic target in pancreatic adenocarcinoma.
Early Antibiotic Treatment for Severe Acute Necrotizing Pancreatitis: A Randomized, Double-Blind, Placebo-Controlled Study
This study demonstrated no statistically significant difference between the treatment groups for pancreatic or peripancreatic infection, mortality, or requirement for surgical intervention, and did not support early prophylactic antimicrobial use in patients with severe acute necrotizing pancreatitis.
Ligation of EphA2 by Ephrin A1-Fc inhibits pancreatic adenocarcinoma cellular invasiveness.
Necrotizing Pancreatitis: Contemporary Analysis of 99 Consecutive Cases
It is suggested that conservative strategies can be applied successfully to manage most patients with necrotizing pancreatitis, although some will eventually require surgery for symptomatic organized necrosis.
Inhibition of Src Tyrosine Kinase Impairs Inherent and Acquired Gemcitabine Resistance in Human Pancreatic Adenocarcinoma Cells
- M. Duxbury, Hiromichi Ito, M. Zinner, S. Ashley, E. Whang
- Biology, ChemistryClinical Cancer Research
- 1 April 2004
Increased Src tyrosine kinase activity represents a potential chemoresistance mechanism and a promising therapeutic target warranting further investigation in gemcitabine-resistant pancreatic adenocarcinoma.
Exogenous ghrelin modulates release of pro-inflammatory and anti-inflammatory cytokines in LPS-stimulated macrophages through distinct signaling pathways.
CEACAM6 gene silencing impairs anoikis resistance and in vivo metastatic ability of pancreatic adenocarcinoma cells
CEACAM6 gene silencing reversed the acquired anoikis resistance of MiaAR and inhibited its in vivo metastatic ability and warrants further investigation as a novel therapeutic target for the treatment of pancreatic adenocarcinoma.
Laparoscopic cholecystectomy. The new 'gold standard'?
Laparoscopic cholecystectomy is regarded as the "gold standard" therapy for management of symptomatic cholelithiasis.
Crisis checklists for the operating room: development and pilot testing.