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EphA2: a determinant of malignant cellular behavior and a potential therapeutic target in pancreatic adenocarcinoma
TLDR
EphA1 siRNA suppresses EphA2 expression, cellular invasiveness, anoikis resistance and FAK phosphorylation in vitro and retards tumor growth and inhibits metastasis in vivo and is both a determinant of malignant cellular behavior and a potential therapeutic target in pancreatic adenocarcinoma. Expand
Early Antibiotic Treatment for Severe Acute Necrotizing Pancreatitis: A Randomized, Double-Blind, Placebo-Controlled Study
TLDR
This study demonstrated no statistically significant difference between the treatment groups for pancreatic or peripancreatic infection, mortality, or requirement for surgical intervention, and did not support early prophylactic antimicrobial use in patients with severe acute necrotizing pancreatitis. Expand
Inhibition of Src Tyrosine Kinase Impairs Inherent and Acquired Gemcitabine Resistance in Human Pancreatic Adenocarcinoma Cells
TLDR
Increased Src tyrosine kinase activity represents a potential chemoresistance mechanism and a promising therapeutic target warranting further investigation in gemcitabine-resistant pancreatic adenocarcinoma. Expand
Ligation of EphA2 by Ephrin A1-Fc inhibits pancreatic adenocarcinoma cellular invasiveness.
TLDR
It is shown that EphA2 overexpression induces a FAK-dependent increase in MMP-2 expression and invasiveness and ligation by Ephrin A1-Fc is one strategy to modulate levels of this oncoprotein. Expand
Necrotizing Pancreatitis: Contemporary Analysis of 99 Consecutive Cases
TLDR
It is suggested that conservative strategies can be applied successfully to manage most patients with necrotizing pancreatitis, although some will eventually require surgery for symptomatic organized necrosis. Expand
Crisis checklists for the operating room: development and pilot testing.
TLDR
Checklist use can improve safety and management in operating room crises and warrant broader evaluation, including in clinical settings. Expand
Laparoscopic cholecystectomy. The new 'gold standard'?
TLDR
Laparoscopic cholecystectomy is regarded as the "gold standard" therapy for management of symptomatic cholelithiasis. Expand
CEACAM6 gene silencing impairs anoikis resistance and in vivo metastatic ability of pancreatic adenocarcinoma cells
TLDR
CEACAM6 gene silencing reversed the acquired anoikis resistance of MiaAR and inhibited its in vivo metastatic ability and warrants further investigation as a novel therapeutic target for the treatment of pancreatic adenocarcinoma. Expand
Interleukin-10 prevents early cytokine release in severe intraabdominal infection and sepsis.
TLDR
The hypothesis that CLP produces an early systemic rise in macrophage-derived cytokines and IL-10 given either before or after the onset of CLP-induced intraabdominal infection and sepsis is able to inhibit this early release of macrophages-derived systemic mediators is supported. Expand
Appendiceal adenocarcinoma: Long-term outcomes after surgical therapy
TLDR
Patients undergoing surgery for appendiceal adenocarcinoma can be stratified according to prognostic variables and the role of adjuvant therapies for patients with poor prognostic factors needs to be evaluated in a multi-institutional setting. Expand
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