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Protein Tyrosine Kinase
Known as:
Tyrosine Protein Kinases
, Tyrosine-Specific Protein Kinases
, Tyrosylprotein Kinase
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Kinases that phosphorylate protein tyrosine residues. These kinases play major roles in mitogenic signalling, and can be divided into two subfamilies…
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National Institutes of Health
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Related topics
Related topics
49 relations
Narrower (31)
Bmx protein, mouse
Bmx protein, rat
EPHA4 protein, human
Ephrin Receptor EphB1
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Cell Differentiation process
Cell Proliferation
Enzyme Gene
Extracellular Signal Regulated Kinases
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness
M. Nishita
,
Seung-Yeol Park
,
+9 authors
Y. Minami
Scientific Reports
2017
Corpus ID: 2760407
Signaling through the Ror2 receptor tyrosine kinase promotes invadopodia formation for tumor invasion. Here, we identify…
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Highly Cited
2004
Highly Cited
2004
EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
J. Paez
,
P. Jänne
,
+14 authors
M. Meyerson
Science
2004
Corpus ID: 13275861
Receptor tyrosine kinase genes were sequenced in non–small cell lung cancer (NSCLC) and matched normal tissue. Somatic mutations…
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Highly Cited
2004
Highly Cited
2004
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.
T. Lynch
,
D. Bell
,
+11 authors
D. Haber
New England Journal of Medicine
2004
Corpus ID: 27937216
BACKGROUND Most patients with non-small-cell lung cancer have no response to the tyrosine kinase inhibitor gefitinib, which…
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Review
2001
Review
2001
Oncogenic kinase signalling
P. Blume-Jensen
,
T. Hunter
Nature
2001
Corpus ID: 4428819
Protein-tyrosine kinases (PTKs) are important regulators of intracellular signal-transduction pathways mediating development and…
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Highly Cited
2000
Highly Cited
2000
Structural mechanism for STI-571 inhibition of abelson tyrosine kinase.
T. Schindler
,
W. Bornmann
,
P. Pellicena
,
W. Miller
,
B. Clarkson
,
J. Kuriyan
Science
2000
Corpus ID: 957274
The inadvertent activation of the Abelson tyrosine kinase (Abl) causes chronic myelogenous leukemia (CML). A small-molecule…
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Highly Cited
1996
Highly Cited
1996
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells
B. Druker
,
S. Tamura
,
+5 authors
N. Lydon
Nature Network Boston
1996
Corpus ID: 36102747
The bcr–abl oncogene, present in 95% of patients with chronic myelogenous leukemia (CML), has been implicated as the cause of…
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Review
1995
Review
1995
The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification 1
S. Hanks
,
T. Hunter
The FASEB Journal
1995
Corpus ID: 21377422
The eukaryotic protein kinases make up a large superfamily of homologous proteins. They are related by virtue of their kinase…
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Review
1995
Review
1995
Protein Kinase C: Structure, Function, and Regulation (*)
A. Newton
Journal of Biological Chemistry
1995
Corpus ID: 28248489
The protein kinase C family of enzymes transduces the myriad of signals promoting lipid hydrolysis. The prevalence of this enzyme…
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Highly Cited
1993
Highly Cited
1993
Signaling by Receptor Tyrosine Kinases
W. Fantl
1993
Corpus ID: 140107518
The epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane gly-coprotein tyrosine receptor…
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Review
1990
Review
1990
Signal transduction by receptors with tyrosine kinase activity
A. Ullrich
,
J. Schlessinger
Cell
1990
Corpus ID: 33090799
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