Protein Tyrosine Kinase

Known as: Tyrosine Protein Kinases, Tyrosine-Specific Protein Kinases, Tyrosylprotein Kinase 
Kinases that phosphorylate protein tyrosine residues. These kinases play major roles in mitogenic signalling, and can be divided into two subfamilies… (More)
National Institutes of Health

Related topics

Related topics

49 relations
Cell Differentiation processCell ProliferationEnzyme GeneExtracellular Signal Regulated Kinases
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Narrower (27)

Dyrk kinaseEPHA4 protein, humanEphrin Receptor EphB1Ephrin Type-A Receptor 1, human
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Anaplastic thyroid carcinoma: from clinicopathology to genetics and advanced therapies
Anaplastic thyroid carcinoma (ATC) is a rare malignancy, accounting for 1–2% of all thyroid cancers. Although rare, ATC accounts… (More)
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Review
2017
Review
2017
A central role for cadherin signaling in cancer.
Cadherins are homophilic adhesion molecules with important functions in cell-cell adhesion, tissue morphogenesis, and cancer. In… (More)
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Review
2017
Review
2017
Inhibition of the fibroblast growth factor receptor (FGFR) pathway: the current landscape and barriers to clinical application
The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) is a tyrosine kinase signaling pathway that has a… (More)
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Review
2017
Review
2017
Rituximab treatment of myasthenia gravis: A systematic review.
Rituximab is a chimeric mouse/human anti-CD20 monoclonal immunoglobulin. We reviewed the efficacy and safety of rituximab in 169… (More)
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Review
2017
Review
2017
ALK: a tyrosine kinase target for cancer therapy
The anaplastic lymphoma kinase (ALK) gene plays an important physiologic role in the development of the brain and can be… (More)
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Review
2017
Review
2017
Neurobiology of local and intercellular BDNF signaling
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of secreted proteins. Signaling cascades induced… (More)
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Highly Cited
2006
Highly Cited
2006
mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt.
Stimulation of the insulin and insulin-like growth factor I (IGF-I) receptor activates the phosphoinositide-3-kinase/Akt/mTOR… (More)
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Highly Cited
2003
Highly Cited
2003
Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia.
Preeclampsia, a syndrome affecting 5% of pregnancies, causes substantial maternal and fetal morbidity and mortality. The… (More)
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Highly Cited
2000
Highly Cited
2000
Molecular portraits of human breast tumours
Human breast tumours are diverse in their natural history and in their responsiveness to treatments. Variation in transcriptional… (More)
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Highly Cited
1996
Highly Cited
1996
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells
The bcr–abl oncogene, present in 95% of patients with chronic myelogenous leukemia (CML), has been implicated as the cause of… (More)
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