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Protein Tyrosine Kinase

Known as: Tyrosine Protein Kinases, Tyrosine-Specific Protein Kinases, Tyrosylprotein Kinase 
Kinases that phosphorylate protein tyrosine residues. These kinases play major roles in mitogenic signalling, and can be divided into two subfamilies… Expand
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
Signaling through the Ror2 receptor tyrosine kinase promotes invadopodia formation for tumor invasion. Here, we identify… Expand
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Highly Cited
2004
Highly Cited
2004
Receptor tyrosine kinase genes were sequenced in non–small cell lung cancer (NSCLC) and matched normal tissue. Somatic mutations… Expand
Review
2004
Review
2004
Tyrosine phosphorylation is catalyzed by protein tyrosine kinases, which are represented by 90 genes in the human genome. Here… Expand
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Most patients with non-small-cell lung cancer have no response to the tyrosine kinase inhibitor gefitinib, which… Expand
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Review
2001
Review
2001
Protein-tyrosine kinases (PTKs) are important regulators of intracellular signal-transduction pathways mediating development and… Expand
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Review
2000
Review
2000
Members of the IR family 550 First Avenue are disulfide linked dimers of two polypeptide chains New York, New York 10016 forming… Expand
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Highly Cited
2000
Highly Cited
2000
The inadvertent activation of the Abelson tyrosine kinase (Abl) causes chronic myelogenous leukemia (CML). A small-molecule… Expand
Highly Cited
1996
Highly Cited
1996
The bcr–abl oncogene, present in 95% of patients with chronic myelogenous leukemia (CML), has been implicated as the cause of… Expand
Review
1995
Review
1995
A number of different intracellular signaling pathways have been shown to be activated by receptor tyrosine kinases. These… Expand
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Review
1995
Review
1995
  • S. Hanks, T. Hunter
  • FASEB journal : official publication of the…
  • 1995
  • Corpus ID: 21377422
The eukaryotic protein kinases make up a large superfamily of homologous proteins. They are related by virtue of their kinase… Expand