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Protein Tyrosine Kinase

Known as: Tyrosine Protein Kinases, Tyrosine-Specific Protein Kinases, Tyrosylprotein Kinase 
Kinases that phosphorylate protein tyrosine residues. These kinases play major roles in mitogenic signalling, and can be divided into two subfamilies… 
National Institutes of Health

Related topics

Related topics

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Narrower (31)

Bmx protein, mouseBmx protein, ratEPHA4 protein, humanEphrin Receptor EphB1
Cell Differentiation processCell ProliferationEnzyme GeneExtracellular Signal Regulated Kinases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness
Signaling through the Ror2 receptor tyrosine kinase promotes invadopodia formation for tumor invasion. Here, we identify… 
Highly Cited
2004
Highly Cited
2004
EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
Receptor tyrosine kinase genes were sequenced in non–small cell lung cancer (NSCLC) and matched normal tissue. Somatic mutations… 
Highly Cited
2004
Highly Cited
2004
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.
BACKGROUND Most patients with non-small-cell lung cancer have no response to the tyrosine kinase inhibitor gefitinib, which… 
Review
2001
Review
2001
Oncogenic kinase signalling
Protein-tyrosine kinases (PTKs) are important regulators of intracellular signal-transduction pathways mediating development and… 
Highly Cited
2000
Highly Cited
2000
Structural mechanism for STI-571 inhibition of abelson tyrosine kinase.
The inadvertent activation of the Abelson tyrosine kinase (Abl) causes chronic myelogenous leukemia (CML). A small-molecule… 
Highly Cited
1996
Highly Cited
1996
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells
The bcr–abl oncogene, present in 95% of patients with chronic myelogenous leukemia (CML), has been implicated as the cause of… 
Review
1995
Review
1995
The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification 1
The eukaryotic protein kinases make up a large superfamily of homologous proteins. They are related by virtue of their kinase… 
Review
1995
Review
1995
Protein Kinase C: Structure, Function, and Regulation (*)
  • A. Newton
  • Journal of Biological Chemistry
  • 1995
  • Corpus ID: 28248489
The protein kinase C family of enzymes transduces the myriad of signals promoting lipid hydrolysis. The prevalence of this enzyme… 
Highly Cited
1993
Highly Cited
1993
Signaling by Receptor Tyrosine Kinases
The epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane gly-coprotein tyrosine receptor… 
Review
1990
Review
1990
Signal transduction by receptors with tyrosine kinase activity
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