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Signaling through the Ror2 receptor tyrosine kinase promotes invadopodia formation for tumor invasion. Here, we identify… Expand Receptor tyrosine kinase genes were sequenced in non–small cell lung cancer (NSCLC) and matched normal tissue. Somatic mutations… Expand Tyrosine phosphorylation is catalyzed by protein tyrosine kinases, which are represented by 90 genes in the human genome. Here… Expand BACKGROUND
Most patients with non-small-cell lung cancer have no response to the tyrosine kinase inhibitor gefitinib, which… Expand Protein-tyrosine kinases (PTKs) are important regulators of intracellular signal-transduction pathways mediating development and… Expand Members of the IR family 550 First Avenue are disulfide linked dimers of two polypeptide chains New York, New York 10016 forming… Expand The inadvertent activation of the Abelson tyrosine kinase (Abl) causes chronic myelogenous leukemia (CML). A small-molecule… Expand The bcr–abl oncogene, present in 95% of patients with chronic myelogenous leukemia (CML), has been implicated as the cause of… Expand A number of different intracellular signaling pathways have been shown to be activated by receptor tyrosine kinases. These… Expand The eukaryotic protein kinases make up a large superfamily of homologous proteins. They are related by virtue of their kinase… Expand