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EPHA4 protein, human

Known as: EC 2.7.1.112, Receptor Protein-Tyrosine Kinase HEK8, TYRO1 Protein Tyrosine Kinase 
Ephrin type-A receptor 4 (986 aa, ~110 kDa) is encoded by the human EPHA4 gene. This protein plays a role in neuronal morphology, cell-cell signaling… 
National Institutes of Health

Related topics

Related topics

28 relations
Axon GuidanceCell Differentiation processCell ProliferationEPHA4 gene

Broader (2)

EphB2 ReceptorProtein Tyrosine Kinase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
EphA4-dependent Brachyury expression is required for dorsal mesoderm involution in the Xenopus gastrula
Xenopus provides a well-studied model of vertebrate gastrulation, but a central feature, the movement of the mesoderm to the… 
2012
2012
Loss of EphA4 impairs short‐term spatial recognition memory performance and locomotor habituation
EphA4 receptor (EphA4) tyrosine kinase is an important regulator of central nervous system development and synaptic plasticity in… 
2012
2012
Involvement of the γ‐Secretase‐Mediated EphA4 Signaling Pathway in Synaptic Pathogenesis of Alzheimer's Disease
Loss of synapses is associated with cognitive impairment in Alzheimer's disease (AD). However, the molecular mechanism underlying… 
2011
2011
A Disalicylic Acid‐Furanyl Derivative Inhibits Ephrin Binding to a Subset of Eph Receptors
Eph receptor tyrosine kinases and ephrin ligands control many physiological and pathological processes, and molecules interfering… 
2011
2011
Genetic Dissection of EphA Receptor Signaling Dynamics during Retinotopic Mapping
Retinal ganglion cells (RGCs) project axons from their cell bodies in the eye to targets in the superior colliculus of the… 
2009
2009
β2‐Chimaerin binds to EphA receptors and regulates cell migration
Highly Cited
2008
Highly Cited
2008
Temporal regulation of ephrin/Eph signalling is required for the spatial patterning of the mammalian striatum
Brain structures, whether mature or developing, display a wide diversity of pattern and shape, such as layers, nuclei or segments… 
2007
2007
Deletion of EphA4 enhances deafferentation‐induced ipsilateral sprouting in auditory brainstem projections
Axonal selection of ipsilateral and/or contralateral targets is essential for integrating bilateral sensory information and for… 
2006
2006
Temporal regulation of EphA4 in astroglia during murine retinal and optic nerve development
2002
2002
EphA4 catalytic activity causes inhibition of RhoA GTPase in Xenopus laevis embryos.
The Eph family of receptor tyrosine kinases is involved in limiting cell and tissue interactions via a repulsive mechanism. The… 
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