Skip to search formSkip to main contentSkip to account menu

EPHA4 protein, human

Known as: EC 2.7.1.112, Receptor Protein-Tyrosine Kinase HEK8, TYRO1 Protein Tyrosine Kinase 
Ephrin type-A receptor 4 (986 aa, ~110 kDa) is encoded by the human EPHA4 gene. This protein plays a role in neuronal morphology, cell-cell signaling… 
National Institutes of Health

Related topics

Related topics

28 relations
Axon GuidanceCell Differentiation processCell ProliferationEPHA4 gene

Broader (2)

EphB2 ReceptorProtein Tyrosine Kinase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport
Astrocytes are critical participants in synapse development and function, but their role in synaptic plasticity is unclear. Eph… 
Highly Cited
2009
Highly Cited
2009
Synaptic activity prompts γ-secretase–mediated cleavage of EphA4 and dendritic spine formation
Alzheimer's disease is an age-dependent neurodegenerative disorder that is characterized by a progressive decline in cognitive… 
Highly Cited
2007
Highly Cited
2007
α2-Chimaerin Is an Essential EphA4 Effector in the Assembly of Neuronal Locomotor Circuits
Highly Cited
2007
Highly Cited
2007
The EphA4 receptor regulates dendritic spine remodeling by affecting β1-integrin signaling pathways
Remodeling of dendritic spines is believed to modulate the function of excitatory synapses. We previously reported that the EphA4… 
Highly Cited
2004
Highly Cited
2004
Hippocampal plasticity requires postsynaptic ephrinBs
Chemical synapses contain specialized pre- and postsynaptic structures that regulate synaptic transmission and plasticity. EphB… 
Highly Cited
2004
Highly Cited
2004
Aberrant Expression of the Tyrosine Kinase Receptor EphA4 and the Transcription Factor Twist in Sézary Syndrome Identified by Gene Expression Analysis
Sézary syndrome (Sz) is a malignancy of CD4+ memory skin-homing T cells and presents with erythroderma, lymphadenopathy, and… 
Highly Cited
2001
Highly Cited
2001
Ephrin-B3 is the midline barrier that prevents corticospinal tract axons from recrossing, allowing for unilateral motor control.
Growing axons follow highly stereotypical pathways, guided by a variety of attractive and repulsive cues, before establishing… 
Highly Cited
1998
Highly Cited
1998
Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane region
The cellular components of the neuronal signaling pathways of Eph receptor tyrosine kinases are only beginning to be elucidated… 
Highly Cited
1998
Highly Cited
1998
Segmental expression of the EphA4 (Sek-1) receptor tyrosine kinase in the hindbrain is under direct transcriptional control of Krox-20.
Segmentation of the vertebrate hindbrain leads to the formation of a series of rhombomeres (r) with distinct identities. Recent… 
Highly Cited
1998
Highly Cited
1998
Expression and tyrosine phosphorylation of Eph receptors suggest multiple mechanisms in patterning of the visual system.
The EphA3 receptor tyrosine kinase has been implicated in guiding the axons of retinal ganglion cells as they extend in the optic… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)