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Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125.
Retinoic acid-inducible gene I (RIG-I) plays a pivotal role in the regulation of cytokine production induced by pathogens. The RIG-I also augments the production of IFN and other cytokines via anExpand
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Hormonal induction of all stages of spermatogenesis in vitro in the male Japanese eel (Anguilla japonica).
The importance of gonadotropins and androgens for spermatogenesis is generally accepted in vertebrates, but the role played by specific hormones has not been clarified. Under cultivation conditions,Expand
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Visualization, direct isolation, and transplantation of midbrain dopaminergic neurons
To visualize and isolate live dopamine (DA)-producing neurons in the embryonic ventral mesencephalon, we generated transgenic mice expressing green fluorescent protein (GFP) under the control of theExpand
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TDP‐43 mutation in familial amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder. Accumulating evidence has shown that 43kDa TAR‐DNA–binding protein (TDP‐43) is the disease protein in ALS and frontotemporalExpand
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Proposal for a new clinical entity, IgG4-positive multiorgan lymphoproliferative syndrome: analysis of 64 cases of IgG4-related disorders
Background: Mikulicz’s disease (MD) has been considered as one manifestation of Sjögren’s syndrome (SS). Recently, it has also been considered as an IgG4-related disorder. Objective: To determine theExpand
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TDP-43 immunoreactivity in neuronal inclusions in familial amyotrophic lateral sclerosis with or without SOD1 gene mutation
Recently, 43-kDa TAR DNA-binding protein (TDP-43) was identified as a component of ubiquitinated inclusions (UIs) in sporadic amyotrophic lateral sclerosis (SALS). To clarify whether TDP-43Expand
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Inorganic polyphosphate and the induction of rpoS expression.
Inorganic polyphosphate [poly(P)] levels in Escherichia coli were reduced to barely detectable concentrations by expression of the plasmid-borne gene for a potent yeast exopolyphosphataseExpand
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Late‐onset frontotemporal dementia with a novel exon 1 (Arg5His) tau gene mutation
We report a case of frontotemporal dementia and parkinsonism linked to chromosome 17 of 5 years' duration in an 81‐year‐old man whose brother had died at age 86 years with dementia. In this patient,Expand
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Neuropathology of autonomic nervous system in Parkinson's disease.
Lewy body formation has been considered to be a marker for neuronal degeneration, because postmortem studies of Parkinson's disease (PD) patients have shown loss of neurons in the predilection sitesExpand
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Parkinson's disease: the presence of Lewy bodies in Auerbach's and Meissner's plexuses
SummaryWe systematically studied the enteric nervous system of the alimentary tract in seven patients with Parkinson's disease. In all patients, characteristic inclusions histologically andExpand
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