• Publications
  • Influence
Eph receptors and ephrins in cancer: bidirectional signalling and beyond
  • E. Pasquale
  • Biology, Medicine
  • Nature Reviews Cancer
  • 1 March 2010
The Eph receptor tyrosine kinases and their ephrin ligands have intriguing expression patterns in cancer cells and tumour blood vessels, which suggest important roles for their bidirectional signalsExpand
Eph receptor signalling casts a wide net on cell behaviour
  • E. Pasquale
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
  • 1 July 2005
TLDR
In this article, the axons in parts (b) and (c) of Box 2 should be purple, and not blue, to indicate the co-expression of ephrin-As and EphA receptors. Expand
Eph-Ephrin Bidirectional Signaling in Physiology and Disease
TLDR
New findings reveal that Eph receptors and ephrins coordinate not only developmental processes but also the normal physiology and homeostasis of many adult organs, and balance of Eph/ephrin function may contribute to a variety of diseases. Expand
Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling
TLDR
The data support a model in which transient interactions between the ephrin-A3 ligand and the EphA4 receptor regulate the structure of excitatory synaptic connections through neuroglial cross-talk. Expand
Shared and distinct functions of RAGS and ELF‐1 in guiding retinal axons
TLDR
Two ligands for Eph‐related receptor tyrosine kinases, RAGS and ELF‐1, have been implicated in the control of development of the retinotectal projection and their biological activities correlate with the strength of interaction with their receptors expressed on RGC axons. Expand
The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl–Crk pathway
TLDR
It is reported that the EphB4 receptor can behave as a tumour suppressor in a mouse xenograft model of breast cancer when stimulated by its ligand, ephrin-B2, and it is predicted that therapeutic intervention to activate Eph B4 signalling will inhibit tumour progression. Expand
The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization
TLDR
Data suggest that ephrin-A1 and EphA2 play a role in human cancers, at least in part by influencing tumor neovascularization, and may represent promising new targets for antiangiogenic cancer treatments. Expand
Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport
TLDR
It is shown that long-term potentiation (LTP) at the CA3–CA1 synapse is modulated by EphA4 in the postsynaptic CA1 cell and by ephrin-A3, a ligand of EPhA4 that is found in astrocytes, suggesting that Eph a4/ephrin-A 3 signaling is a critical mechanism for astroCytes to regulate synaptic function and plasticity. Expand
Tyrosine Phosphorylation of Transmembrane Ligands for Eph Receptors
TLDR
It is proposed that transmembrane ligands of Eph receptors act not only as conventional RTK ligands but also as receptorlike signaling molecules. Expand
Molecular mechanisms of dendritic spine development and remodeling
TLDR
The molecules that are currently known to mediate the exquisite sensitivity of spines to perturbations in their environment are discussed and it is outlined how these molecules interface with each other to mediated cascades of signals flowing from the spine surface to the actin cytoskeleton. Expand
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