EphA2: a determinant of malignant cellular behavior and a potential therapeutic target in pancreatic adenocarcinoma

@article{Duxbury2004EphA2AD,
  title={EphA2: a determinant of malignant cellular behavior and a potential therapeutic target in pancreatic adenocarcinoma},
  author={Mark S. Duxbury and Hiromichi Ito and M. J. Zinner and Stanley W Ashley and Edward E. Whang},
  journal={Oncogene},
  year={2004},
  volume={23},
  pages={1448-1456}
}
The EphA2 receptor tyrosine kinase is overexpressed in a variety of human cancers. We sought to characterize the role of EphA2 in pancreatic adenocarcinoma and, using RNA interference (RNAi) mediated by small interfering RNA (siRNA), we determined the effects of suppressing EphA2 expression in vitro and in vivo. EphA2 expression in PANC1, MIAPaCa2, BxPC3 and Capan2 cells was assessed by Northern and Western blot. We artificially overexpressed EphA2 by transient transfection and suppressed EphA2… CONTINUE READING