• Publications
  • Influence
Comprehensive molecular characterization of human colon and rectal cancer
TLDR
Integrative analyses suggest new markers for aggressive colorectal carcinoma and an important role for MYC-directed transcriptional activation and repression. Expand
Risk Factors for Retained Instruments and Sponges after Surgery
TLDR
The medical records associated with all claims or incident reports of a retained surgical sponge or instrument filed between 1985 and 2001 with a large malpractice insurer representing one third of the physicians in Massachusetts were reviewed. Expand
An Apgar score for surgery.
TLDR
An Apgar score for the field of surgery was developed, an outcomes score that teams could calculate at the end of any general or vascular surgical procedure to accurately grade a patient's condition and chances of major complications or death. Expand
EphA2: a determinant of malignant cellular behavior and a potential therapeutic target in pancreatic adenocarcinoma
TLDR
EphA1 siRNA suppresses EphA2 expression, cellular invasiveness, anoikis resistance and FAK phosphorylation in vitro and retards tumor growth and inhibits metastasis in vivo and is both a determinant of malignant cellular behavior and a potential therapeutic target in pancreatic adenocarcinoma. Expand
Incidence, patterns, and prevention of wrong-site surgery.
TLDR
Wrong-site surgery is unacceptable but exceedingly rare, and major injury from wrong- site surgery is even rarer, and current site-verification protocols could have prevented only two thirds of the examined cases. Expand
Patterns of communication breakdowns resulting in injury to surgical patients.
TLDR
Interventions to prevent serious communication breakdowns should involve: defined triggers that mandate communication with an attending surgeon; structured handoffs and transfer protocols; and standard use of read-backs. Expand
Analysis of errors reported by surgeons at three teaching hospitals.
TLDR
Subjective incident reports gathered through interviews allow identification of characteristics of surgical errors and their leading contributing factors, which may help target research and interventions to reduce such errors. Expand
Patterns of Communication Breakdowns Resulting in Injury to Surgical Patients
TLDR
Serious communication breakdowns occur across the continuum of care, typically result from a failure in verbal communication between a surgical attending and another caregiver, and often involve ambiguity about responsibilities. Expand
Inhibition of Src Tyrosine Kinase Impairs Inherent and Acquired Gemcitabine Resistance in Human Pancreatic Adenocarcinoma Cells
TLDR
Increased Src tyrosine kinase activity represents a potential chemoresistance mechanism and a promising therapeutic target warranting further investigation in gemcitabine-resistant pancreatic adenocarcinoma. Expand
The incidence and nature of surgical adverse events in Colorado and Utah in 1992.
TLDR
A retrospective chart review of 15,000 randomly selected admissions to Colorado and Utah hospitals during 1992 provided direction for research to identify the causes of surgical adverse events and for targeted quality improvement efforts. Expand
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