Dizocilpine Maleate

Known as: 5H-Dibenzo(a,d)cyclohepten-5,10-imine, 10,11-dihydro-5-methyl-, (5S)-, (Z)-2-butenedioate (1:1), Dizocilpine Maleate [Chemical/Ingredient] 
A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been… (More)
National Institutes of Health

Papers overview

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Review
2008
Review
2008
In the United States stroke is the third leading cause of death and the leading cause of disability. Brain injury following… (More)
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Highly Cited
2006
Highly Cited
2006
Central nervous system myelin is a specialized structure produced by oligodendrocytes that ensheaths axons, allowing rapid and… (More)
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Highly Cited
2005
Highly Cited
2005
A substantial decrease in the number of synapses occurs in the mammalian brain from the late postnatal period until the end of… (More)
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Highly Cited
1997
Highly Cited
1997
These studies were designed to determine whether adult neurogenesis occurs in the dentate gyrus of the tree shrew, an animal… (More)
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Highly Cited
1997
Highly Cited
1997
We have used endocytotic uptake of the styryl dye FM1-43 at synaptic terminals (Betz and Bewick, 1992) to study properties of… (More)
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Highly Cited
1997
Highly Cited
1997
Neuronal apoptosis was observed in the rat dentate gyrus in two experimental models of human limbic epilepsy. Five hours after… (More)
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Highly Cited
1996
Highly Cited
1996
Diffusion-weighted single voxel experiments conducted at b-values up to 1 x 10(4) smm-2 yielded biexponential signal attenuation… (More)
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Highly Cited
1993
Highly Cited
1993
An impairment of energy metabolism may underlie slow excitotoxic neuronal death in neurodegenerative diseases. We therefore… (More)
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Highly Cited
1993
Highly Cited
1993
MK(+)801 (dizocilpine maleate) is a noncompetitive antagonist at the N-methyl-D-aspartate (NMDA) receptor, the major glutamate… (More)
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Highly Cited
1991
Highly Cited
1991
Repetitive stimulation of small diameter primary afferent fibres produces a progressive increase in action potential discharge… (More)
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