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Dizocilpine Maleate

Known as: 5H-Dibenzo(a,d)cyclohepten-5,10-imine, 10,11-dihydro-5-methyl-, (5S)-, (Z)-2-butenedioate (1:1), Dizocilpine Maleate [Chemical/Ingredient] 
A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been… Expand
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
BACKGROUND Ketamine exerts a robust, rapid, and relatively sustained antidepressant effect in patients with major depression… Expand
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Review
1998
Review
1998
Angiotensin (ANG) II is a powerful and phylogenetically widespread stimulus to thirst and sodium appetite. When it is injected… Expand
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Highly Cited
1997
Highly Cited
1997
These studies were designed to determine whether adult neurogenesis occurs in the dentate gyrus of the tree shrew, an animal… Expand
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Highly Cited
1997
Highly Cited
1997
Neuronal apoptosis was observed in the rat dentate gyrus in two experimental models of human limbic epilepsy. Five hours after… Expand
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Highly Cited
1993
Highly Cited
1993
An impairment of energy metabolism may underlie slow excitotoxic neuronal death in neurodegenerative diseases. We therefore… Expand
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Highly Cited
1991
Highly Cited
1991
&NA; Repetitive stimulation of small diameter primary afferent fibres produces a progressive increase in action potential… Expand
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Highly Cited
1991
Highly Cited
1991
The N-methyl-D-aspartate (NMDA) subtype of the glutamate receptor is an important mediator of several forms of neural and… Expand
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Review
1989
Review
1989
'The following abbreviations have been used in the text; I3-L-ODAP, I3-N-uxalyl-L-a,l3diaminu-prupiunic acid; ACPD, Trans-l-aminu… Expand
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Highly Cited
1989
Highly Cited
1989
Phencyclidine (PCP), a dissociative anesthetic and widely abused psychotomimetic drug, and MK-801, a potent PCP receptor ligand… Expand
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Highly Cited
1986
Highly Cited
1986
The compound MK-801 [(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cyclohepten-5,10-imine maleate)] is a potent anticonvulsant that… Expand
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