Skip to search formSkip to main contentSkip to account menu

Dizocilpine Maleate

Known as: 5H-Dibenzo(a,d)cyclohepten-5,10-imine, 10,11-dihydro-5-methyl-, (5S)-, (Z)-2-butenedioate (1:1), Dizocilpine Maleate [Chemical/Ingredient] 
A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been… 
National Institutes of Health

Related topics

Related topics

14 relations

Broader (5)

AnticonvulsantsDibenzocycloheptenesExcitatory Amino Acid AntagonistsNeuroprotective Agents

Narrower (2)

DizocilpineMK-801
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1999
Highly Cited
1999
Effects of cocaine, nicotine, dizocipline and alcohol on mice locomotor activity: cocaine–alcohol cross-sensitization involves upregulation of striatal dopamine transporter binding sites
Highly Cited
1997
Highly Cited
1997
Chronic ethanol increases N-methyl-D-aspartate-stimulated nitric oxide formation but not receptor density in cultured cortical neurons.
The effects of prolonged ethanol exposure on excitatory amino acid receptor stimulated nitric oxide (NO) formation were examined… 
Highly Cited
1995
Highly Cited
1995
At least two mechanisms are involved in the death of retinal ganglion cells following target ablation in neonatal rats
Removal of the superior colliculus (SC) in neonatal Wistar rats results in a rapid loss of retinal ganglion cells (RGCs). There… 
Highly Cited
1991
Highly Cited
1991
Brain regional specificity and time-course of changes in the NMDA receptor-ionophore complex during ethanol withdrawal
Highly Cited
1990
Highly Cited
1990
The interactions between plasma membrane depolarization and glutamate receptor activation in the regulation of cytoplasmic free calcium in cultured cerebellar granule cells
The complex modulation of cytoplasmic free calcium concentration ([Ca2+]c) in primary cultures of cerebellar granule cells in… 
Highly Cited
1990
Highly Cited
1990
The neurotoxicity of ouabain, a sodium-potassium ATPase inhibitor, in the rat hippocampus
Highly Cited
1990
Highly Cited
1990
Protective effect of MK801 in experimental brain injury.
The effect of a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, MK801, was studied in a model of closed head… 
Highly Cited
1989
Highly Cited
1989
Hypobaric-ischemic conditions produce glutamate-like cytopathology in infant rat brain
We present a new animal model of perinatal hypoxic/ischemic brain damage and compare this type of brain damage with the… 
Highly Cited
1989
Highly Cited
1989
Posthypoxic treatment with MK‐801 reduces hypoxic‐ischemic damage in the neonatal rat
We evaluated the neuroprotective effect of MK-801, a noncompetitive, selective N-methyl-D-aspartate receptor antagonist, in a… 
Highly Cited
1988
Highly Cited
1988
Anticonvulsant action of a non-competitive antagonist of NMDA receptors (MK-801) in the kindling model of epilepsy
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)