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Dizocilpine Maleate

Known as: 5H-Dibenzo(a,d)cyclohepten-5,10-imine, 10,11-dihydro-5-methyl-, (5S)-, (Z)-2-butenedioate (1:1), Dizocilpine Maleate [Chemical/Ingredient] 
A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been… 
National Institutes of Health

Related topics

Related topics

14 relations

Broader (5)

AnticonvulsantsDibenzocycloheptenesExcitatory Amino Acid AntagonistsNeuroprotective Agents

Narrower (2)

DizocilpineMK-801
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2006
2006
The drug-induced helplessness test: an animal assay for assessing behavioral despair in response to neuroleptic treatment
RationaleNeuroleptic dysphoria encompasses a range of unpleasant subjective responses and, as a result, is difficult to study in… 
2000
2000
Behavioral interactions caused by combined administration of morphine and MK-801 in rats
Abstract Rationale: The NMDA antagonist MK-801 reportedly blocks experience-dependent changes in sensitivity to morphine… 
2000
2000
On the interactions between antimuscarinic atropine and NMDA receptor antagonists in anticholinesterase-treated mice
Abstract. Both organophosphate (OP) and carbamate pesticides may produce seizures and death commonly attributed to the inhibition… 
1997
1997
Roles of GABA, glutamate, acetylcholine and STN stimulation on thalamic VM in rats
THE effects of high frequency stimulation of the subthalamic nucleus (STN) and of iontophoretic application of different… 
1995
1995
Reversal of stable behavioural modifications through NMDA receptor inhibition in rats
In order to study the effect of long-term dizocilpine infusion on memory, two different paradigms of stably modified behaviour… 
Highly Cited
1994
Highly Cited
1994
Anticonvulsant and antilethal effects of the phencyclidine derivative TCP in soman poisoning.
The protection afforded by TCP (thienylcylohexylpiperidine), a non-competitive blocker of N-methyl-D-aspartate (NMDA) receptors… 
1994
1994
NBQX reduces threshold of protein synthesis inhibition in focal ischaemia in rats
The effect of the AMPA antagonist NBQX on peri-infarct inhibition of cerebral protein synthesis (CPS) was studied in rats… 
1994
1994
Glutamatergic regulation of [3H]-noradrenaline release in the medulla oblongata of normotensive and spontaneously hypertensive rats
Objective To assess in vitro the role of glutamate receptors in the regulation of noradrenaline release from the medulla… 
1992
1992
Discriminative‐stimulus control by morphine in the pigeon under a fixed‐interval schedule of reinforcement
The stimulus control by morphine under a fixed-interval (FI) 180-s schedule of reinforcement was examined in five pigeons trained… 
1991
1991
The N-methyl-D-aspartate receptor antagonist MK-801 delays the onset of puberty and may acutely block the first spontaneous LH surge and ovulation in the rat.
The physiological role of activated hypothalamic N-methyl-D-aspartate (NMDA) receptors during the final phase of female sexual… 
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