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Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome.
The deleterious effects of ethanol on the developing human brain are poorly understood. Here it is reported that ethanol, acting by a dual mechanism [blockade of N-methyl-D-aspartate (NMDA) glutamate… Expand
Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain.
Programmed cell death (apoptosis) occurs during normal development of the central nervous system. However, the mechanisms that determine which neurons will succumb to apoptosis are poorly understood.… Expand
Review: cholinergic mechanisms and epileptogenesis. The seizures induced by pilocarpine: a novel experimental model of intractable epilepsy.
High-dose treatment with pilocarpine hydrochloride, a cholinergic muscarinic agonist, induces seizures in rodents following systemic or intracerebral administration. Pilocarpine seizures are… Expand
Long‐Term Effects of Pilocarpine in Rats: Structural Damage of the Brain Triggers Kindling and Spontaneous I Recurrent Seizures
- E. Cavalheiro, J. P. Leite, Z. Bortolotto, W. Turski, C. Ikonomidou, L. Turski
- 1 December 1991
Summary: Structural damage of the human brain (perinatal damage, cerebral trauma, head injury, cerebrovascular and degenerative diseases, intracranial tumor, metabolic diseases, toxins, drug‐induced… Expand
Antiepileptic drugs and apoptotic neurodegeneration in the developing brain
- P. Bittigau, M. Sifringer, +9 authors C. Ikonomidou
- Proceedings of the National Academy of Sciences…
- 4 November 2002
Epilepsy is the most common neurological disorder of young humans. Each year 150,000 children in the United States experience their first seizure. Antiepileptic drugs (AEDs), used to treat seizures… Expand
Ethanol-induced apoptotic neurodegeneration in the developing C57BL/6 mouse brain.
- J. Olney, T. Tenkova, K. Dikranian, Yue-Qin Qin, J. Labruyere, C. Ikonomidou
- Biology, Medicine
- Brain research. Developmental brain research
- 28 February 2002
Recent studies have shown that administration of ethanol to infant rats during the synaptogenesis period (first 2 weeks after birth), triggers extensive apoptotic neurodegeneration throughout many… Expand
Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses
- S. Papadia, Francesc X Soriano, +16 authors G. Hardingham
- Biology, Medicine
- Nature Neuroscience
- 1 April 2008
Intrinsic antioxidant defenses are important for neuronal longevity. We found that in rat neurons, synaptic activity, acting via NMDA receptor (NMDAR) signaling, boosted antioxidant defenses by… Expand
Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?
Glutamate N-methyl-D-aspartate (NMDA) receptor antagonists (competitive receptor antagonists, ion channel blockers, and glycine antagonists)--such as selfotel, aptiganel, eliprodil, licostinel and… Expand
Expanding the phenotypic spectrum of lupus erythematosus in Aicardi-Goutières syndrome.
OBJECTIVE Aicardi-Goutières syndrome (AGS) is an early-onset encephalopathy resembling congenital viral infection that is characterized by basal ganglia calcifications, loss of white matter,… Expand
Antiepileptic drugs and apoptosis in the developing brain.
- P. Bittigau, M. Sifringer, C. Ikonomidou
- Annals of the New York Academy of Sciences
- 1 May 2003
Epilepsy is the most common neurologic disorder in young humans. Antiepileptic drugs (AEDs), used to treat seizures in children, infants, and pregnant women, cause cognitive impairment, microcephaly,… Expand