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Regulatory networks define phenotypic classes of human stem cell lines
Stem cells are defined as self-renewing cell populations that can differentiate into multiple distinct cell types. However, hundreds of different human cell lines from embryonic, fetal and adultExpand
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Cell culture: Progenitor cells from human brain after death
Culturing neural progenitor cells from the adult rodent brain has become routine and is also possible from human fetal tissue, but expansion of these cells from postnatal and adult human tissue,Expand
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Neuropathology of fragile X-associated tremor/ataxia syndrome (FXTAS).
Fragile X-associated tremor/ataxia syndrome (FXTAS) is an adult-onset neurodegenerative disorder that affects carriers, principally males, of premutation alleles (55-200 CGG repeats) of the fragile XExpand
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Human neural stem cell growth and differentiation in a gradient-generating microfluidic device.
This paper describes a gradient-generating microfluidic platform for optimizing proliferation and differentiation of neural stem cells (NSCs) in culture. Microfluidic technology has great potentialExpand
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Isolation and characterization of neural progenitor cells from post‐mortem human cortex
Post‐mortem human brain tissue represents a vast potential source of neural progenitor cells for use in basic research as well as therapeutic applications. Here we describe five human neuralExpand
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Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease
Intracranial transplantation of neural stem cells (NSCs) delayed disease onset, preserved motor function, reduced pathology and prolonged survival in a mouse model of Sandhoff disease, a lethalExpand
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Regulation of human neural precursor cells by laminin and integrins
Deciphering the factors that regulate human neural stem cells will greatly aid in their use as models of development and as therapeutic agents. The extracellular matrix (ECM) is a component of stemExpand
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Oxygen tension controls the expansion of human CNS precursors and the generation of astrocytes and oligodendrocytes
Human neural precursor proliferation and potency is limited by senescence and loss of oligodendrocyte potential. We found that in vitro expansion of human postnatal brain CD133(+) nestin(+)Expand
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Human Cytomegalovirus Infection Causes Premature and Abnormal Differentiation of Human Neural Progenitor Cells
ABSTRACT Congenital human cytomegalovirus (HCMV) infection is a leading cause of birth defects, largely manifested as central nervous system (CNS) disorders. The principal site of manifestations inExpand
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Acute toxicity studies with insect attractants.
Abstract Eight insect attractants and one inhibitor of a sex attractant were tested for acute oral and aerosol inhalation toxicity in rats, for acute dermal toxicity, eye irritation, and primary skinExpand
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