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DX 619

Known as: DX-619, DX619 compound 
National Institutes of Health

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2 relations

Broader (2)

PyrrolidinesQuinolones

Papers overview

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2010
2010
Chondrotoxicity and toxicokinetics of novel quinolone antibacterial agents DC-159a and DX-619 in juvenile rats.
2007
2007
Lack of Effect of DX-619, a Novel Des-Fluoro(6)-Quinolone, on Glomerular Filtration Rate Measured by Serum Clearance of Cold Iohexol
ABSTRACT DX-619 is a novel des-fluoro(6)-quinolone with activity against a broad range of bacterial strains, including… 
2007
2007
Susceptibilities of healthcare- and community-associated methicillin-resistant staphylococci to the novel des-F(6)-quinolone DX-619.
OBJECTIVES The aim of the study was to test in vitro activities of the novel des-F(6)-quinolone DX-619 against methicillin… 
2006
2006
In Vitro Activities of DX-619 and Comparison Quinolones against Gram-Positive Cocci
ABSTRACT The in vitro activity of the novel quinolone DX-619 was compared to those of currently available quinolones against U.S… 
2006
2006
In Vivo Efficacies and Pharmacokinetics of DX-619, a Novel Des-Fluoro(6) Quinolone, against Streptococcus pneumoniae in a Mouse Lung Infection Model
ABSTRACT DX-619 is a novel des-fluoro(6) quinolone with potent activity against gram-positive pathogens. The in vivo activity of… 
2006
2006
In Vitro Activity of DX-619, a Novel Des-Fluoro(6) Quinolone, against a Panel of Streptococcus pneumoniae Mutants with Characterized Resistance Mechanisms
ABSTRACT The in vitro activities of DX-619 and four other quinolones were compared against Streptococcus pneumoniae mutants that… 
2006
2006
Intracellular Penetration and Activity of DX-619 in Human Polymorphonuclear Leukocytes
ABSTRACT The intracellular penetration and activity of DX-619 in human polymorphonuclear leukocytes have been evaluated. DX-619… 
2005
2005
In Vitro Antibacterial Activity of DX-619, a Novel Des-Fluoro(6) Quinolone
ABSTRACT The in vitro activities of DX-619, des-fluoro(6) quinolone, against 1,208 clinical isolates were examined. DX-619 was… 
2005
2005
DX-619, a Novel Des-Fluoro(6) Quinolone Manifesting Low Frequency of Selection of Resistant Staphylococcus aureus Mutants: Quinolone Resistance beyond Modification of Type II Topoisomerases
ABSTRACT DX-619, a novel des-fluoro(6) quinolone, was 16- to 32-fold, twofold, and four- to eightfold more potent than… 
2005
2005
Postantibiotic Effect of DX-619 against 16 Gram-Positive Organisms
ABSTRACT The in vitro postantibiotic effects (PAEs), the postantibiotic sub-MIC effects (PA-SMEs), and the sub-MIC effects (SMEs… 
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