Quinolones

Known as: Quinolinones, Oxoquinolines, Quinolones [Chemical/Ingredient] 
A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.
National Institutes of Health

Papers overview

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Review
2009
Review
2009
Although plasmid-mediated quinolone resistance (PMQR) was thought not to exist before its discovery in 1998, the past decade has… (More)
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Review
2009
Review
2009
The quinolones trap DNA gyrase and DNA topoisomerase IV on DNA as complexes in which the DNA is broken but constrained by protein… (More)
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Review
2006
Review
2006
Fluoroquinolone resistance is emerging in gram-negative pathogens worldwide. The traditional understanding that quinolone… (More)
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Review
2005
Review
2005
Although quinolone resistance results mostly from chromosomal mutations in Enterobacteriaceae, it may also be mediated by plasmid… (More)
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Review
2003
Review
2003
Since their discovery in the early 1960s, the quinolone group of antibacterials has generated considerable clinical and… (More)
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Highly Cited
2002
Highly Cited
2002
Quinolones are potent antibacterial agents that specifically target bacterial DNA gyrase and topoisomerase IV. Widespread use of… (More)
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Highly Cited
1999
Highly Cited
1999
Numerous species of bacteria use an elegant regulatory mechanism known as quorum sensing to control the expression of specific… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Bacteria can mutate to acquire quinolone resistance by target alterations or diminished drug accumulation. Plasmid… (More)
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Review
1997
Review
1997
For many years, DNA gyrase was thought to be responsible both for unlinking replicated daughter chromosomes and for controlling… (More)
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Highly Cited
1995
Highly Cited
1995
We have demonstrated that, in Escherichia coli, quinolone antimicrobial agents target topoisomerase IV (topo IV). The inhibition… (More)
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