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The study of antibiotic resistance has been historically concentrated on the analysis of bacterial pathogens and on the… Expand SUMMARY Although plasmid-mediated quinolone resistance (PMQR) was thought not to exist before its discovery in 1998, the past… Expand Fluoroquinolone resistance is emerging in gram-negative pathogens worldwide. The traditional understanding that quinolone… Expand SUMMARY Extended-spectrum β-lactamases (ESBLs) are a rapidly evolving group of β-lactamases which share the ability to hydrolyze… Expand The increased use of fluoroquinolones has led to increasing resistance to these antimicrobials, with rates of resistance that… Expand Quinolones are broad-spectrum antibacterial agents, commonly used in both clinical and veterinary medicine. Their extensive use… Expand Quinolones are potent antibacterial agents that specifically target bacterial DNA gyrase and topoisomerase IV. Widespread use of… Expand Numerous species of bacteria use an elegant regulatory mechanism known as quorum sensing to control the expression of specific… Expand BACKGROUND
Bacteria can mutate to acquire quinolone resistance by target alterations or diminished drug accumulation. Plasmid… Expand For many years, DNA gyrase was thought to be responsible both for unlinking replicated daughter chromosomes and for controlling… Expand