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Susceptibilities of Streptococcus pneumoniae and Haemophilus influenzae to 10 Oral Antimicrobial Agents Based on Pharmacodynamic Parameters: 1997 U.S. Surveillance Study
TLDR
With the continuing rise in resistance, judicious use of oral antimicrobial agents is necessary in all age groups.
Susceptibilities of Penicillin- and Erythromycin-Susceptible and -Resistant Pneumococci to HMR 3647 (RU 66647), a New Ketolide, Compared with Susceptibilities to 17 Other Agents
TLDR
HMR 3647 had the best kill kinetics of all macrolides tested against 11 erythromycin-susceptible and -resistant strains, with uniform bactericidal activity.
Activity of Meropenem with and without Ciprofloxacin and Colistin against Pseudomonas aeruginosa and Acinetobacter baumannii
TLDR
Time-kill synergy studies showed that at 24 h, subinhibitory meropenem and ciprofloxacin concentrations of 0.06 to 128 and 0.03 to 32 μg/ml showed synergy against 34/51 Pseudomonas aeruginosa strains.
In Vitro Development of Resistance to Five Quinolones and Amoxicillin-Clavulanate in Streptococcus pneumoniae
TLDR
In contrast to the case for quinolones, subculturing in the presence of amoxicillin-clavulanate did not select for resistance to this drug.
Antipneumococcal Activity of ABT-773 Compared to Those of 10 Other Agents
TLDR
ABT-773 shows promising in vitro activity against macrolide-susceptible as well as -resistant pneumococci, and had longer PAEs than macrolides, azithromycin, clindamycin, or β-lactams, including against ermB-containing strains.
Activities of Tizoxanide and Nitazoxanide Compared to Those of Five Other Thiazolides and Three Other Agents against Anaerobic Species
TLDR
Agar dilution was used, and metronidazole MICs were usually lower against all groups except clostridia, andNitazoxanide and tizoxanides were active against allgroups, except for gram-positive non-spore-forming rods with 50% minimum inhibitory concentrations.
Placental Microbiology and Histology and the Pathogenesis of Chorioamnionitis
TLDR
Findings of the present study increase the possibility that bacteria are responsible for most cases of Chorioamnionitis.
Antipneumococcal Activities of Gemifloxacin Compared to Those of Nine Other Agents
TLDR
Gemifloxacin was uniformly bactericidal after 24 h at ≤0.5 μg/ml, compared with MICs ranging between 0.25 and >32.0 μg/ ml for other quinolones and some degree of killing at earlier time points, and Resistance in these 28 strains was associated with mutations in parC, gyrA,parE, and/or gyrB or efflux.
Activity of Telavancin against Staphylococci and Enterococci Determined by MIC and Resistance Selection Studies
TLDR
Telavancin demonstrated potent activity against all vancomycin-susceptible isolates as well as against heterogeneously VISA and VISA resistance phenotypes, and two enterococci developed resistance to daptomycin, and one developing resistance to linezolid.
Susceptibilities of 123 strains of Xanthomonas maltophilia to eight beta-lactams (including beta-lactam-beta-lactamase inhibitor combinations) and ciprofloxacin tested by five methods
TLDR
Good correlation between the methods was observed, with ticarcillin-clavulanate clearly the most active beta-lactam by all four methods, but correlation was also poor, with many major and very major discrepancies for all methods tested.
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