• Publications
  • Influence
Extended-Spectrum-β-Lactamase, AmpC, and Carbapenemase Issues
  • K. Thomson
  • Biology, Medicine
    Journal of Clinical Microbiology
  • 24 February 2010
TLDR
This Commentary focuses on the detection of ESBL resistance in gram-negative pathogens, the most important countermeasure against multidrug-resistant gram- negative pathogens in the absence of new, effective anti-gram-negative antibiotics.
Occurrence and Detection of AmpC Beta-Lactamases among Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis Isolates at a Veterans Medical Center
TLDR
A three-dimensional extract test was described, which was used to detect phenotypically isolates that harbor AmpC beta-lactamase, and confirmed that, at this institution, E. coli, K. pneumoniae, and P. mirabilis harbor plasmid-mediated AmpC enzymes.
Detection of extended-spectrum beta-lactamases in members of the family Enterobacteriaceae: comparison of the double-disk and three-dimensional tests
TLDR
The three-dimensional and clavulanate double-disk potentiation tests were compared as procedures for the detection of extended-spectrum beta-lactamase production in 32 strains of Escherichia coli and Klebsiella pneumoniae, offering the advantages of providing simultaneous information about both antibiotic susceptibility and extended- Spectrum beta- lactamases production.
AmpC Disk Test for Detection of Plasmid-Mediated AmpC β-Lactamases in Enterobacteriaceae Lacking Chromosomal AmpC β-Lactamases
TLDR
A new test, the AmpC disk test, based on filter paper disks impregnated with EDTA, was found to be a highly sensitive, specific, and convenient means of detection of plasmid-mediated AmpC β-lactamases in organisms lacking a chromosomally mediated AmpCβ- lactamase.
β-Lactamases Responsible for Resistance to Expanded-Spectrum Cephalosporins in Klebsiella pneumoniae, Escherichia coli, and Proteus mirabilis Isolates Recovered in South Africa
TLDR
This is the first study which has identified organisms producing different extended-spectrum β-lactamases from South Africa and the first report describing strains of P. mirabilis producing a TEM-26-type enzyme.
Controversies about extended-spectrum and AmpC beta-lactamases.
  • K. Thomson
  • Biology, Medicine
    Emerging infectious diseases
  • 1 March 2001
TLDR
Clinical laboratories need to have adequate funding, equipment, and expertise to provide a rapid and clinically relevant antibiotic testing service in centers where these resistance mechanisms are encountered.
Plasmid-mediated, carbapenem-hydrolysing beta-lactamase, KPC-2, in Klebsiella pneumoniae isolates.
TLDR
Four isolates of Klebsiella pneumoniae obtained from patients at a Maryland medical centre exhibited reduced susceptibility to carbapenems and were found to produce the novel, class A, plasmid-mediated,carbapenem-hydrolysing enzyme, KPC-2, which was associated with positive extended-spectrum beta-lactamase (ESBL) confirmation tests.
Molecular characterization of a multiply resistant Klebsiella pneumoniae encoding ESBLs and a plasmid-mediated AmpC.
TLDR
A multiply resistant Klebsiella pneumoniae is described which possesses at least five different beta-lactamase genes and southern analysis and conjugation experiments established that most of the resistance genes were encoded on one large transferable plasmid.
Plasmid-Mediated Resistance to Expanded-Spectrum Cephalosporins among Enterobacter aerogenesStrains
ABSTRACT Resistance to expanded-spectrum cephalosporins commonly develops inEnterobacter aerogenes during therapy due to selection of mutants producing high levels of the chromosomal Bush group 1
Plasmid-Mediated Carbapenem-Hydrolyzing Enzyme KPC-2 in an Enterobacter sp
ABSTRACT A strain of an Enterobacter sp. with reduced susceptibility to imipenem, which produced a plasmid-mediated class A carbapenem-hydrolyzing enzyme, KPC-2 β-lactamase, was isolated from a
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