• Publications
  • Influence
Extended-Spectrum-β-Lactamase, AmpC, and Carbapenemase Issues
  • K. Thomson
  • Biology, Medicine
  • Journal of Clinical Microbiology
  • 24 February 2010
Optimal use of microbiology laboratories is essential to combat the spread of multiply antibiotic-resistant pathogens. This is vital for patient care, as advocated by Jarvis in stressing theExpand
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Occurrence and Detection of AmpC Beta-Lactamases among Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis Isolates at a Veterans Medical Center
ABSTRACT AmpC beta-lactamases are cephalosporinases that confer resistance to a wide variety of β-lactam drugs and that may thereby create serious therapeutic problems. Although reported withExpand
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Detection of extended-spectrum beta-lactamases in members of the family Enterobacteriaceae: comparison of the double-disk and three-dimensional tests.
The three-dimensional and clavulanate double-disk potentiation tests were compared as procedures for the detection of extended-spectrum beta-lactamase production in 32 strains of Escherichia coli andExpand
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Controversies about extended-spectrum and AmpC beta-lactamases.
  • K. Thomson
  • Biology, Medicine
  • Emerging infectious diseases
  • 1 March 2001
Many clinical laboratories have problems detecting extended-spectrum beta-lactamases (ESBLs) and plasmid-mediated AmpC beta-lactamases. Confusion exists about the importance of these resistanceExpand
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Plasmid-mediated, carbapenem-hydrolysing beta-lactamase, KPC-2, in Klebsiella pneumoniae isolates.
Four isolates of Klebsiella pneumoniae obtained from patients at a Maryland medical centre exhibited reduced susceptibility to carbapenems and were found to produce the novel, class A,Expand
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AmpC Disk Test for Detection of Plasmid-Mediated AmpC β-Lactamases in Enterobacteriaceae Lacking Chromosomal AmpC β-Lactamases
ABSTRACT Although plasmid-mediated AmpC β-lactamases were first reported in the late 1980s, many infectious disease personnel remain unaware of their clinical importance. These enzymes are typicallyExpand
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β-Lactamases Responsible for Resistance to Expanded-Spectrum Cephalosporins in Klebsiella pneumoniae, Escherichia coli, and Proteus mirabilis Isolates Recovered in South Africa
ABSTRACT Although resistance to the expanded-spectrum cephalosporins among members of the family Enterobacteriaceae lacking inducible β-lactamases occurs virtually worldwide, little is known aboutExpand
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Molecular characterization of a multiply resistant Klebsiella pneumoniae encoding ESBLs and a plasmid-mediated AmpC.
Organisms encoding multiple antibiotic resistance genes are becoming increasingly prevalent. In this report we describe a multiply resistant Klebsiella pneumoniae which possesses at least fiveExpand
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Plasmid-Mediated Resistance to Expanded-Spectrum Cephalosporins among Enterobacter aerogenesStrains
ABSTRACT Resistance to expanded-spectrum cephalosporins commonly develops inEnterobacter aerogenes during therapy due to selection of mutants producing high levels of the chromosomal Bush group 1Expand
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Plasmid-Mediated Carbapenem-Hydrolyzing Enzyme KPC-2 in an Enterobacter sp
ABSTRACT A strain of an Enterobacter sp. with reduced susceptibility to imipenem, which produced a plasmid-mediated class A carbapenem-hydrolyzing enzyme, KPC-2 β-lactamase, was isolated from aExpand
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