DNA Sequence Rearrangement

Known as: Rearrangement, Rearrangements 
Any process affecting a DNA sequence that results in the gain, loss or exchange of DNA between chromosomes and/or autonomous replicons.
National Institutes of Health

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BCL2 Gene Rear Bld/T QlChromosome region 6q22 rearrangements:Find:Pt:Tiss:Doc:FISHImmunoglobulin heavy chain gene rearrangements:Arb:Pt:Bone mar:Ord:MolgenMAML2 11q21 gene rearrangements:Prid:Pt:Tiss:Nar:FISH
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Papers overview

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Review
2017
Review
2017
Diagnosis and classification of hematologic malignancies on the basis of genetics.
Genomic analysis has greatly influenced the diagnosis and clinical management of patients affected by diverse forms of… (More)
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Review
2016
Review
2016
Regulation of disease-associated gene expression in the 3D genome
Genetic variation associated with disease often appears in non-coding parts of the genome. Understanding the mechanisms by which… (More)
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Highly Cited
2011
Highly Cited
2011
Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development
Cancer is driven by somatically acquired point mutations and chromosomal rearrangements, conventionally thought to accumulate… (More)
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Highly Cited
2010
Highly Cited
2010
progressiveMauve: Multiple Genome Alignment with Gene Gain, Loss and Rearrangement
BACKGROUND Multiple genome alignment remains a challenging problem. Effects of recombination including rearrangement, segmental… (More)
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Highly Cited
2009
Highly Cited
2009
COMPLEX LANDSCAPES OF SOMATIC REARRANGEMENT IN HUMAN BREAST CANCER GENOMES
Multiple somatic rearrangements are often found in cancer genomes; however, the underlying processes of rearrangement and their… (More)
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Highly Cited
2007
Highly Cited
2007
A DNA Replication Mechanism for Generating Nonrecurrent Rearrangements Associated with Genomic Disorders
The prevailing mechanism for recurrent and some nonrecurrent rearrangements causing genomic disorders is nonallelic homologous… (More)
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Highly Cited
2004
Highly Cited
2004
Mauve: multiple alignment of conserved genomic sequence with rearrangements.
As genomes evolve, they undergo large-scale evolutionary processes that present a challenge to sequence comparison not posed by… (More)
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Review
2002
Review
2002
Genome architecture, rearrangements and genomic disorders.
An increasing number of human diseases are recognized to result from recurrent DNA rearrangements involving unstable genomic… (More)
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Review
1998
Review
1998
Genomic disorders: structural features of the genome can lead to DNA rearrangements and human disease traits.
Molecular medicine began with Pauling's seminal work, which recognized sickle-cell anemia as a molecular disease, and with Ingram… (More)
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Highly Cited
1992
Highly Cited
1992
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
We have generated mice that carry a germline mutation in which a large portion of the RAG-2 coding region is deleted. Homozygous… (More)
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