AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

@article{PetersenMahrt2002AIDME,
  title={AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification},
  author={S. Petersen-Mahrt and R. Harris and M. Neuberger},
  journal={Nature},
  year={2002},
  volume={418},
  pages={99-104}
}
After gene rearrangement, immunoglobulin variable genes are diversified by somatic hypermutation or gene conversion, whereas the constant region is altered by class-switch recombination. All three processes depend on activation-induced cytidine deaminase (AID), a B-cell-specific protein that has been proposed (because of sequence homology) to function by RNA editing. But indications that the three gene diversification processes might be initiated by a common type of DNA lesion, together with… Expand
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