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FGF23 induces left ventricular hypertrophy.
TLDR
It is reported that elevated FGF23 levels are independently associated with LVH in a large, racially diverse CKD cohort and suggested that chronically elevated F GF23 levels contribute directly to high rates of LVH and mortality in individuals with CKD. Expand
TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function
TLDR
It is shown that the canonical transient receptor potential 6 (TRPC6) ion channel is expressed in podocytes and is a component of the glomerular slit diaphragm. Expand
Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines.
TLDR
The determinative steps of podocyte differentiation and process formation are studied for the first time using an inducible in vitro model and electrophysiological studies demonstrate that differentiated MPC cells respond to the vasoactive peptide bradykinin by changes in intracellular calcium concentration. Expand
Synaptopodin: An Actin-associated Protein in Telencephalic Dendrites and Renal Podocytes
TLDR
It is concluded that synaptopodin represents a novel kind of proline-rich, actin-associated protein that may play a role in modulating actin -based shape and motility of dendritic spines and podocyte foot processes. Expand
A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression.
TLDR
The development of this conditionally immortalized human podocyte cell line provides a new tool in the study of podocyte biology, which will enable accurate assessment of the behavior of these complex cells in health and disease. Expand
Induction of B7-1 in podocytes is associated with nephrotic syndrome.
TLDR
Upregulation of B7-1 in podocytes may contribute to the pathogenesis of proteinuria by disrupting the glomerular filter and provides a novel molecular target to tackle proteinuric kidney diseases. Expand
The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A
TLDR
It is shown that the beneficial effect of CsA on proteinuria is not dependent on NFAT inhibition in T cells, but rather results from the stabilization of the actin cytoskeleton in kidney podocytes, preserving the phosphorylation-dependent synaptopodin–14-3-3β interaction. Expand
Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin.
TLDR
It is shown, by immunoelectron microscopy, that podocin localizes to the podocyte foot process membrane, at the insertion site of the slit diaphragm, and it is postulate thatpodocin serves in the structural organization of the slat diaphagm and the regulation of its filtration function. Expand
Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy
TLDR
Ectopically expressed RAF1 mutants from the two HCM hotspots had increased kinase activity and enhanced ERK activation, whereas non–HCM-associated mutants were kinase impaired, which implicate increased RAS signaling in pathological cardiomyocyte hypertrophy. Expand
The glomerular slit diaphragm is a modified adherens junction.
TLDR
A P-cadherin-based adherens junction is well-suited to explain the zipper-like structure of the slit diaphragm, and the present study should allow new avenues leading to the identification of additional slit diphragm-associated proteins conferring specificity to this unique cell junction. Expand
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