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Structure and gating mechanism of the acetylcholine receptor pore
The nicotinic acetylcholine receptor controls electrical signalling between nerve and muscle cells by opening and closing a gated, membrane-spanning pore. Here we present an atomic model of theExpand
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Structural determinants of water permeation through aquaporin-1
Human red cell AQP1 is the first functionally defined member of the aquaporin family of membrane water channels. Here we describe an atomic model of AQP1 at 3.8 Å resolution from electronExpand
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Structure of the connexin 26 gap junction channel at 3.5 Å resolution
Gap junctions consist of arrays of intercellular channels between adjacent cells that permit the exchange of ions and small molecules. Here we report the crystal structure of the gap junction channelExpand
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Atomic model of plant light-harvesting complex by electron crystallography
The structure of the light-harvesting chlorophyll a/b–protein complex, an integral membrane protein, has been determined at 3.4 Å resolution by electron crystallography of two-dimensional crystals.Expand
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Functional role of internal water molecules in rhodopsin revealed by x-ray crystallography
Activation of G protein-coupled receptors (GPCRs) is triggered and regulated by structural rearrangement of the transmembrane heptahelical bundle containing a number of highly conserved residues. InExpand
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Aquaporin water channels – from atomic structure to clinical medicine
The water permeability of biological membranes has been a longstanding problem in physiology, but the proteins responsible for this remained unknown until discovery of the aquaporin 1 (AQP1) waterExpand
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Nicotinic acetylcholine receptor at 4.6 A resolution: transverse tunnels in the channel wall.
The nicotinic acetylcholine (ACh) receptor is the neurotransmitter-gated ion channel responsible for the rapid propagation of electrical signals between cells at the nerve/muscle synapse. We reportExpand
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Lipid–protein interactions in double-layered two-dimensional AQP0 crystals
Lens-specific aquaporin-0 (AQP0) functions as a specific water pore and forms the thin junctions between fibre cells. Here we describe a 1.9 Å resolution structure of junctional AQP0, determined byExpand
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Lipid–protein interactions in double-layered two-dimensional AQP0 crystals
Lens-specific aquaporin-0 (AQP0) functions as a specific water pore and forms the thin junctions between fibre cells. Here we describe a 1.9 Å resolution structure of junctional AQP0, determined byExpand
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Unique multipotent cells in adult human mesenchymal cell populations
We found adult human stem cells that can generate, from a single cell, cells with the characteristics of the three germ layers. The cells are stress-tolerant and can be isolated from cultured skinExpand
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