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DH Domain

Known as: DBL-Homology Domain, Dbl Homology Domain, RhoGEF Domain 
The Dbl homology (DH) or RhoGEF domain consists of a 150 amino acid region that induces Rho family GTPases to displace GDP. This effectively… Expand
National Institutes of Health

Papers overview

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2007
2007
We identified RECK, a membrane-anchored glycoprotein negatively regulating the activities of MMPs, as a molecule interacting with… Expand
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Highly Cited
2003
Highly Cited
2003
Tuba is a novel scaffold protein that functions to bring together dynamin with actin regulatory proteins. It is concentrated at… Expand
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2003
2003
Intersectin 1L is a scaffolding protein involved in endocytosis that also has guanine nucleotide exchange activity for Cdc42. In… Expand
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Review
2002
Review
2002
The Dbl homology (DH) domain was first identified in the Dbl oncogene product as the limit region required for mediating guanine… Expand
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Highly Cited
2002
Highly Cited
2002
Dbl-related oncoproteins are guanine nucleotide exchange factors (GEFs) specific for Rho guanosine triphosphatases (GTPases) and… Expand
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2001
2001
The dbl oncogene product (onco-Dbl) is the prototype member of a family of guanine nucleotide exchange factors (GEFs) for Rho… Expand
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1999
1999
The full-length versions of the Ras-specific exchange factors Ras-GRF1 (GRF1) and Ras-GRF2 (GRF2), which are expressed in brain… Expand
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Highly Cited
1998
Highly Cited
1998
We have characterized the DH domain protein mNET1, a Rho-family guanine nucleotide exchange factor (GEF). N-terminal truncation… Expand
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Highly Cited
1998
Highly Cited
1998
Guanine nucleotide exchange factors for the Rho family of GTPases contain a Dbl homology (DH) domain responsible for catalysis… Expand
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Highly Cited
1998
Highly Cited
1998
Guanine nucleotide exchange factors in the Dbl family activate Rho GTPases by accelerating dissociation of bound GDP, promoting… Expand
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