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DH Domain

Known as: DBL-Homology Domain, Dbl Homology Domain, RhoGEF Domain 
The Dbl homology (DH) or RhoGEF domain consists of a 150 amino acid region that induces Rho family GTPases to displace GDP. This effectively… 
National Institutes of Health

Related topics

Related topics

12 relations
AKAP13 protein, humanFYVE, RhoGEF and PH Domain-Containing Protein 4ITSN1 protein, humanPhosphatidylinositol 3,4,5-Trisphosphate-Dependent Rac Exchanger 1 Protein

Papers overview

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2010
2010
The RhoA GEF Syx Is a Target of Rnd3 and Regulated via a Raf1-Like Ubiquitin-Related Domain
Background Rnd3 (RhoE) protein belongs to the unique branch of Rho family GTPases that has low intrinsic GTPase activity and… 
2010
2010
Autoinhibition of GEF activity in intersectin 1 is mediated by the short SH3‐DH domain linker
Intersectin 1L (ITSN1L) acts as a specific guanine nucleotide exchange factor (GEF) for the small guanine nucleotide binding… 
Highly Cited
2007
Highly Cited
2007
Crystal Structure of the Rac Activator, Asef, Reveals Its Autoinhibitory Mechanism*
The Rac-specific guanine nucleotide exchange factor (GEF) Asef is activated by binding to the tumor suppressor adenomatous… 
2007
2007
Tgat oncoprotein functions as a inhibitor of RECK by association of the unique C-terminal region.
2004
2004
Preliminary crystallographic analysis of the complex of the human GTPase RhoA with the DH/PH tandem of PDZ-RhoGEF.
PDZ-containing RhoGEF (PDZ-RhoGEF) is a multidomain protein composed of 1522 amino acids that belongs to the guanine nucleotide… 
2001
2001
Identification of splicing variants of Frabin with partly different functions and tissue distribution.
Frabin is a GDP/GTP exchange protein for Cdc42 small G protein with actin filament-binding activity. Frabin consists of the actin… 
2001
2001
DrhoGEF3 encodes a new Drosophila DH domain protein that exhibits a highly dynamic embryonic expression pattern
Abstract. The Rho GTPases regulate many different cellular and developmental processes, and activation of Rho GTPase signalling… 
Highly Cited
2000
Highly Cited
2000
Identification of Rho GTPase-dependent Sites in the Dbl Homology Domain of Oncogenic Dbl That Are Required for Transformation*
The Dbl family guanine-nucleotide exchange factors (GEFs) for Rho GTPases share the structural array of a Dbl homology (DH… 
Highly Cited
1999
Highly Cited
1999
Ras-Specific Exchange Factor GRF: Oligomerization through Its Dbl Homology Domain and Calcium-Dependent Activation of Raf
ABSTRACT The full-length versions of the Ras-specific exchange factors Ras-GRF1 (GRF1) and Ras-GRF2 (GRF2), which are expressed… 
1997
1997
Cloning and Characterization of a rhoGAP Homolog fromDictyostelium discoideum *
Small GTPases interact with a variety of proteins that affect nucleotide binding and cleavage. GTPase activating proteins (GAPs… 
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