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FYVE, RhoGEF and PH Domain-Containing Protein 4

Known as: FGD1-Related F-Actin-Binding Protein, Actin Filament-Binding Protein Frabin, Actin-Filament Binding Protein Frabin 
FYVE, RhoGEF and PH domain-containing protein 4 (766 aa, ~87 kDa) is encoded by the human FGD4 gene. This protein plays a role in regulation of the… Expand
National Institutes of Health

Papers overview

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2009
2009
Background: Charcot Marie Tooth (CMT) disease is a heterogeneous group of inherited peripheral motor and sensory neuropathies… Expand
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Review
2008
Review
2008
•  Introduction •  Molecular structures of frabin and other related GEFs •  Tissue distribution, subcellular localization and… Expand
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Highly Cited
2007
Highly Cited
2007
Charcot-Marie-Tooth (CMT) disorders are a clinically and genetically heterogeneous group of hereditary motor and sensory… Expand
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Highly Cited
2004
Highly Cited
2004
Cryptosporidium parvum invades target epithelia via a mechanism that involves host cell actin reorganization. We previously… Expand
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2004
2004
Mutations in faciogenital dysplasia protein (Fgd1) result in the human disease faciogenital dysplasia (FGDY). Fgd1 contains a… Expand
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Highly Cited
2003
Highly Cited
2003
Background:  Invadopodia are membrane protrusions into the extracellular matrix by aggressive tumour cells. These structures are… Expand
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2002
2002
Background: Frabin is an actin filament (F‐actin)‐binding protein with GDP/GTP exchange activity specific for Cdc42 small G… Expand
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Highly Cited
2000
Highly Cited
2000
Frabin is an actin filament-binding protein which shows GDP/GTP exchange activity specific for Cdc42 small G protein and induces… Expand
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Highly Cited
1999
Highly Cited
1999
We have recently isolated a novel actin filament-binding protein, named frabin. Frabin has one actin filament-binding domain (ABD… Expand
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Highly Cited
1998
Highly Cited
1998
We purified from rat brain a novel F-actin-binding protein with a M r of about 105,000 (p105), which was estimated by SDS… Expand
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