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FYVE, RhoGEF and PH Domain-Containing Protein 4

Known as: FGD1-Related F-Actin-Binding Protein, Actin Filament-Binding Protein Frabin, Actin-Filament Binding Protein Frabin 
FYVE, RhoGEF and PH domain-containing protein 4 (766 aa, ~87 kDa) is encoded by the human FGD4 gene. This protein plays a role in regulation of the… 
National Institutes of Health

Related topics

Related topics

9 relations
Actin-Binding ProteinCytoskeletal ModelingDH DomainFGD4 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
A novel Frabin (FGD4) nonsense mutation p.R275X associated with phenotypic variability in CMT4H
Background: Charcot Marie Tooth (CMT) disease is a heterogeneous group of inherited peripheral motor and sensory neuropathies… 
2009
2009
The amino acid motif L/IIxxFE defines a novel actin-binding sequence in PDZ-RhoGEF.
PDZ-RhoGEF is a member of the regulator family of G protein signaling (RGS) domain-containing RhoGEFs (RGS-RhoGEFs) that link… 
2008
2008
Mutations in FGD 4 encoding the Rho GDP / GTP Exchange Factor FRABIN cause autosomal recessive Charcot-Marie-Tooth type 4 H
Charcot-Marie-Tooth (CMT) disorders are a clinically and genetically heterogeneous group of hereditary motor and sensory… 
Highly Cited
2004
Highly Cited
2004
Phosphatidylinositol 3-Kinase and Frabin Mediate Cryptosporidium parvum Cellular Invasion via Activation of Cdc42*
Cryptosporidium parvum invades target epithelia via a mechanism that involves host cell actin reorganization. We previously… 
2002
2002
Association of frabin with specific actin and membrane structures
Background: Frabin is an actin filament (F‐actin)‐binding protein with GDP/GTP exchange activity specific for Cdc42 small G… 
2001
2001
Cooperation of Cdc42 small G protein-activating and actin filament-binding activities of frabin in microspike formation
Frabin is a GDP/GTP exchange protein for Cdc42 with actin filament (F-actin)-binding activity. Cdc42 is a small GTP-binding… 
Highly Cited
2000
Highly Cited
2000
Two actions of frabin: direct activation of Cdc42 and indirect activation of Rac
Frabin is an actin filament-binding protein which shows GDP/GTP exchange activity specific for Cdc42 small G protein and induces… 
2000
2000
Importance of spatial activation of Cdc42 and Rac small G proteins by frabin for microspike formation in MDCK cells
Frabin is an actin filament (F‐actin)‐binding protein that shows GDP/GTP exchange activity for Cdc42 small G protein (Cdc42… 
Highly Cited
1999
Highly Cited
1999
Association of Frabin with the Actin Cytoskeleton Is Essential for Microspike Formation through Activation of Cdc42 Small G Protein*
We have recently isolated a novel actin filament-binding protein, named frabin. Frabin has one actin filament-binding domain (ABD… 
Highly Cited
1998
Highly Cited
1998
Frabin, a Novel FGD1-related Actin Filament-binding Protein Capable of Changing Cell Shape and Activating c-Jun N-terminal Kinase*
We purified from rat brain a novel F-actin-binding protein with a M r of about 105,000 (p105), which was estimated by SDS… 
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