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Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1.
TLDR
A novel CAZ protein of approximately 120 kD from rat brain is identified and named CAST (CAZ-associated structural protein), which had no transmembrane segment, but had four coiled-coil domains and a putative COOH-terminal consensus motif for binding to PDZ domains. Expand
Nectin/PRR: An Immunoglobulin-like Cell Adhesion Molecule Recruited to Cadherin-based Adherens Junctions through Interaction with Afadin, a PDZ Domain–containing Protein
TLDR
It is found here that afadin directly interacted with a family of the immunoglobulin superfamily, which was isolated originally as the poliovirus receptor–related protein (PRR) family consisting of PRR1 and -2, and has been identified recently to be the alphaherpes virus receptor. Expand
Nectin and afadin: novel organizers of intercellular junctions
TLDR
This novel intercellular adhesion system has roles in the organization of E-cadherin-based adherens junctions and claudin- based tight junctions in epithelial cells and is furthermore involved in the formation of synapses in neurons and the organizations of heterotypic junctions between Sertoli cells and spermatids in the testis. Expand
Ponsin/SH3P12: An l-Afadin– and Vinculin-binding Protein Localized at Cell–Cell and Cell–Matrix Adherens Junctions
TLDR
Results indicate that ponsin is an l-afadin– and vinculin-binding protein localized at ZA in epithelial cells, at cell–cell AJ in nonepithel cells, and at cell-matrix AJ in both types of cells. Expand
Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.
TLDR
The results suggest that PKC zeta may be a target for PIP3 and thus may be involved in the signaling mechanism(s) for growth factors and oncogenes that increase phosphatidylinositol 3-kinase activity. Expand
Nectin: an adhesion molecule involved in formation of synapses.
TLDR
It is shown that at the synapses between the mossy fiber terminals and dendrites of pyramidal cells in the CA3 area of adult mouse hippocampus, the nectin-afadin system colocalizes with the cadherin-catenin system, and nECTin-1 and -3 asymmetrically localize at the pre- and postsynaptic sides of puncta adherentia junctions, respectively. Expand
Afadin: A Novel Actin Filament–binding Protein with One PDZ Domain Localized at Cadherin-based Cell-to-Cell Adherens Junction
TLDR
Results suggest that l-afadin serves as a linker of the actin cytoskeleton to the plasma membrane at cell-to-cell AJ, and is likely to be a rat counterpart of human AF-6 protein. Expand
Nectin Couples Cell-Cell Adhesion and the Actin Scaffold at Heterotypic Testicular Junctions
TLDR
The results indicate that the nectin-afadin system plays essential roles in coupling cell-cell adhesion and the cortical actin scaffold at SspJs and in subsequent sperm morphogenesis. Expand
Rho as a regulator of the cytoskeleton.
TLDR
Evidence is now accumulating that Rho, a Ras-related small GTP-binding protein, is another important regulator of these actin-dependent cell functions. Expand
Isolation and Characterization of a GTPase Activating Protein Specific for the Rab3 Subfamily of Small G Proteins*
TLDR
This work purified a GAP with Rab3A as a substrate from rat brain that was specifically active on the Rab3 subfamily members (Rab3A, -B, -C, and -D), and indicated that Rab3 GAP was ubiquitously expressed. Expand
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