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Small GTP-binding proteins.
In this review, functions of small G proteins and their modes of activation and action are described. Expand
Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.
Kinetic analysis indicates that TPA can substitute for diacylglycerol and greatly increases the affinity of the enzyme for Ca2+ as well as for phospholipid, and various phorbol derivatives which have been shown to be active in tumor promotion are also capable of activating this protein kinase in in vitro systems. Expand
Binding of neuroligins to PSD-95.
PSD-95 is a component of postsynaptic densities in central synapses that contains three PDZ domains that localize N-methyl-D-aspartate receptor subunit 2 (NMDA2 receptor) and K+ channels to synapses and may recruit ion channels and neurotransmitter receptors to intercellular junctions formed between neurons by neuroligins and beta-neurexins. Expand
Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1.
A novel CAZ protein of approximately 120 kD from rat brain is identified and named CAST (CAZ-associated structural protein), which had no transmembrane segment, but had four coiled-coil domains and a putative COOH-terminal consensus motif for binding to PDZ domains. Expand
Nectin/PRR: An Immunoglobulin-like Cell Adhesion Molecule Recruited to Cadherin-based Adherens Junctions through Interaction with Afadin, a PDZ Domain–containing Protein
It is found here that afadin directly interacted with a family of the immunoglobulin superfamily, which was isolated originally as the poliovirus receptor–related protein (PRR) family consisting of PRR1 and -2, and has been identified recently to be the alphaherpes virus receptor. Expand
Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway
Findings indicate that Rho regulates the CD44/ERM complex formation in vivo and that the phosphatidylinositol turnover may be involved in this regulation mechanism. Expand
Nectin and afadin: novel organizers of intercellular junctions
This novel intercellular adhesion system has roles in the organization of E-cadherin-based adherens junctions and claudin- based tight junctions in epithelial cells and is furthermore involved in the formation of synapses in neurons and the organizations of heterotypic junctions between Sertoli cells and spermatids in the testis. Expand
cAMP-GEFII is a direct target of cAMP in regulated exocytosis
Although cAMP is well known to regulate exocytosis in many secretory cells, its direct target in the exocytotic machinery is not known. Here we show that cAMP-GEFII, a cAMP sensor, binds to RimExpand
Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP
It is demonstrated that before it can induce filopodium formation, Cdc42 must bind a WASP-related protein, N-WASP, that is richest in neural tissues but is expressed ubiquitously. Expand
The immunoglobulin-like cell adhesion molecule nectin and its associated protein afadin.
Nectins are immunoglobulin-like cell adhesion molecules (CAMs) that compose a family of four members that homophilic and heterophilically interact in trans with each other to form cell-cell adhesions and regulate many other cellular activities in cooperation with other CAMs and cell surface membrane receptors. Expand