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FGD4 gene

Known as: FRABP, FYVE, RhoGEF, AND PH DOMAIN-CONTAINING PROTEIN 4, FGD4 
This gene plays a role in regulation of the actin cytoskeleton and cell shape.
National Institutes of Health

Related topics

Related topics

5 relations
CHARCOT-MARIE-TOOTH DISEASE, TYPE 4HCytoskeletal ModelingFYVE, RhoGEF and PH Domain-Containing Protein 4Regulation of Cell Shape

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Relation of protein oxidation parameters and disease activity in patients with Behçet's disease.
BACKGROUND Behçet's disease (BD) is a chronic inflammatory vasculitis characterized by endothelial dysfunction, elevated reactive… 
2012
2012
Two novel missense mutations in FGD4/FRABIN cause Charcot‐Marie‐Tooth type 4H (CMT4H)
By sequencing of the FGD4 coding sequence in a cohort of 101 patients affected by autosomal recessive demyelinating Charcot‐Marie… 
Highly Cited
2009
Highly Cited
2009
Further evidence that mutations in FGD4/frabin cause Charcot-Marie-Tooth disease type 4H
Background: Autosomal recessive demyelinating Charcot-Marie-Tooth neuropathy type 4H (CMT4H) manifests early onset, severe… 
2009
2009
The amino acid motif L/IIxxFE defines a novel actin-binding sequence in PDZ-RhoGEF.
PDZ-RhoGEF is a member of the regulator family of G protein signaling (RGS) domain-containing RhoGEFs (RGS-RhoGEFs) that link… 
2005
2005
The Lsc RhoGEF mediates signaling from thromboxane A2 to actin polymerization and apoptosis in thymocytes
The Lsc RhoGEF (also known as p115‐RhoGEF) is a GTP exchange factor (GEF), an activator of GTPases of the Rho family. Lsc has a… 
2002
2002
Association of frabin with specific actin and membrane structures
Background: Frabin is an actin filament (F‐actin)‐binding protein with GDP/GTP exchange activity specific for Cdc42 small G… 
2001
2001
Cooperation of Cdc42 small G protein-activating and actin filament-binding activities of frabin in microspike formation
Frabin is a GDP/GTP exchange protein for Cdc42 with actin filament (F-actin)-binding activity. Cdc42 is a small GTP-binding… 
Highly Cited
2000
Highly Cited
2000
Two actions of frabin: direct activation of Cdc42 and indirect activation of Rac
Frabin is an actin filament-binding protein which shows GDP/GTP exchange activity specific for Cdc42 small G protein and induces… 
2000
2000
Isolation, characterization, and mapping of the mouse Fgd3 gene, a new Faciogenital Dysplasia (FGD1; Aarskog Syndrome) gene homologue.
2000
2000
Importance of spatial activation of Cdc42 and Rac small G proteins by frabin for microspike formation in MDCK cells
Frabin is an actin filament (F‐actin)‐binding protein that shows GDP/GTP exchange activity for Cdc42 small G protein (Cdc42… 
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