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Crystal structure of a bacterial RNA polymerase holoenzyme at 2.6 Å resolution
TLDR
The crystal structure of a bacterial RNA polymerase holoenzyme from Thermus thermophilus at 2.6 Å resolution provides insight into the structural organization of transcription intermediate complexes and into the mechanism of transcription initiation.
A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity
TLDR
AdipoRon showed very similar effects to adiponectin in muscle and liver, such as activation of AMPK and PPAR-α pathways, and ameliorated insulin resistance and glucose intolerance in mice fed a high-fat diet, and is a promising therapeutic approach for the treatment of obesity-related diseases such as type 2 diabetes.
Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis.
TLDR
A strong affinity of the ENTH domain for phosphatidylinositol-4,5-bisphosphate [PtdIns( 4,5)P2] is demonstrated, which is essential for endocytosis mediated by clathrin-coated pits.
An operational RNA code for amino acids and possible relationship to genetic code.
TLDR
Members of the two different classes of tRNA synthetases are, like tRNAs, organized into two major domains, and the emergence of the genetic from the operational RNA code could occur when the second domain of synthetase was added with the anticodon-containing domain of t RNAs.
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