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A brain serine/threonine protein kinase activated by Cdc42 and Rac1
TLDR
A new brain serine/threonine protein kinase may be a target for the p21 ras -related proteins Cdc42 and Rac1, and provides a model for studying p21 regulation of mammalian phosphorylation signalling pathways.
The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton
TLDR
The multidomained ROK alpha appears to be involved in reorganization of the cytoskeleton, with the N and C termini acting as positive and negative regulators, respectively, of the kinase domain whose activity is crucial for formation of stress fibers and focal adhesion complexes.
Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast.
TLDR
A novel yeast STE20 homolog, CLA4, was identified in a screen for mutations lethal in the absence of the G1 cyclins Cln1 and Cln2, and apparently share a function in localizing cell growth with respect to the septin ring.
Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes
TLDR
Transfection shows that in epithelial HeLa cells alpha-PAK is recruited from the cytoplasm to distinct focal complexes by both Cdc42(G 12V) and Rac1(G12V), which themselves colocalize to these sites, which support previous suggestions of a role for PAK downstream of both CDC42 and Rac 1 and indicate that PAK functions include the dissolution of stress fibers and reorganization of focal complexes.
A Conserved Negative Regulatory Region in αPAK: Inhibition of PAK Kinases Reveals Their Morphological Roles Downstream of Cdc42 and Rac1
TLDR
These results, coupled with previous observations with constitutively active PAK, demonstrate that these kinases play an important role downstream of Cdc42 and Rac1 in cytoskeletal reorganization.
A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42
TLDR
The findings indicate that there may be a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation pathway.
PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation.
TLDR
This work focuses on the current understanding of the way in which different Rho-associated serine/threonine kinases, denoted PAK (p21-activated kinase), MLK (mixed-lineage kinase) and ROK (Rho-kinase), interact with and are regulated by their partner GTPases.
PRL-3 down-regulates PTEN expression and signals through PI3K to promote epithelial-mesenchymal transition.
TLDR
Targeting PRL-3 may be a useful strategy to impede cancer cell invasion and metastasis because it could play an initiating role to trigger the EMT switch during cancer metastasis.
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