Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Rac Exchanger 1 Protein
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Regulatory subunits of protein kinase A (PKA) inhibit its kinase subunits. Intriguingly, their potential as cAMP-dependent signal… Expand Significance Genetic alterations targeting the PI3K pathway are highly prevalent in breast cancers. Although breast cancers… Expand Mammalian target of rapamycin complex (mTORC) regulates a variety of cellular responses including proliferation, growth… Expand The Neuregulins and their receptors, the ErbB/HER subfamily of receptor tyrosine kinases, have critical roles in animal… Expand Background: PREX1 maps to a Type 2 diabetes susceptibility locus; however, its role in insulin-stimulated GLUT4 trafficking is… Expand Stromal cell-derived factor-1 (SDF-1/CXCL-12) and vascular endothelial growth factor (VEGF), which can be secreted by hypoxic… Expand Polarized cell migration results from the transduction of extra-cellular cues promoting the activation of Rho GTPases with the… Expand PI 3,4,5‐trisphosphate [PI(3,4,5)P3; PIP3]‐dependent Rac exchanger 1 (P‐Rex1) is a Rac‐specific guanine nucleotide exchange… Expand Rac activation is a key step in chemotaxis of hematopoietic cells, which is both positively and negatively regulated by receptors… Expand P-Rex1 is a guanine-nucleotide exchange factor (GEF) for the small GTPase Rac. We have investigated here the mechanisms of… Expand