Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Rac Exchanger 1 Protein

Known as: P-Rex1, PtdIns(3,4,5)-Dependent Rac Exchanger 1 
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (1659 aa, ~186 kDa) is encoded by the human PREX1 gene. This protein is… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2002-2018
024620022018

Papers overview

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2014
2014
G-protein-coupled receptors (GPCRs) regulate the organisation of the actin cytoskeleton by activating the Rac subfamily of small… (More)
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Highly Cited
2013
Highly Cited
2013
The PI3K pathway is genetically altered in excess of 70% of breast cancers, largely through PIK3CA mutation and HER2… (More)
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2011
2011
Mammalian target of rapamycin complex (mTORC) regulates a variety of cellular responses including proliferation, growth… (More)
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2011
2011
Phosphoinositide 3-kinase (PI3K) signaling promotes the translocation of the glucose transporter, GLUT4, to the plasma membrane… (More)
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Highly Cited
2007
Highly Cited
2007
Polarized cell migration results from the transduction of extra-cellular cues promoting the activation of Rho GTPases with the… (More)
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2007
2007
P-Rex1 is a guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that is directly activated by the betagamma… (More)
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2007
2007
PI 3,4,5-trisphosphate [PI(3,4,5)P3; PIP3]-dependent Rac exchanger 1 (P-Rex1) is a Rac-specific guanine nucleotide exchange… (More)
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2006
2006
Rac activation is a key step in chemotaxis of hematopoietic cells, which is both positively and negatively regulated by receptors… (More)
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2005
2005
P-Rex1 is a guanine-nucleotide exchange factor (GEF) for the small GTPase Rac. We have investigated here the mechanisms of… (More)
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