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Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Rac Exchanger 1 Protein

Known as: P-Rex1, PtdIns(3,4,5)-Dependent Rac Exchanger 1 
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (1659 aa, ~186 kDa) is encoded by the human PREX1 gene. This protein is… 
National Institutes of Health

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7 relations
ApoptosisCytoskeletal ModelingDH DomainPREX1 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Structural Characterization of the DEP Domains of P-Rex1
P-Rex1 is a guanine nucleotide exchange factor for Rho-GTPases, which is indirectly involved in the regulation of cell migration… 
2016
2016
Phorbol myristate acetate suppresses breast cancer cell growth via down-regulation of P-Rex1 expression
Phosphatidylinositol‐3,4,5‐trisphosphate‐dependent Rac exchange factor 1 (P‐Rex1) is highly overexpressed in estrogen receptor… 
2010
2010
Histone Acetylation Up‐regulates Phosphatidylinositol‐3,4,5‐triphosphate‐dependent Rac Exchange Factor 1 (P‐Rex1) Expression to Promote Prostate Cancer Metastasis
We have reported that P‐Rex1 up‐regulation promotes metastasis, the major cause of prostate cancer death (Oncogene, 28: 1853–1863… 
2008
2008
Invesitagating the role of the guanine nucleotide exchange factor P-Rex1 in cell invasion
Cell invasion is a critical step in cancer metastasis. Rho family GTPases are key regulators of cell motility, regulating the… 
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