Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Rac Exchanger 1 Protein

Known as: P-Rex1, PtdIns(3,4,5)-Dependent Rac Exchanger 1 
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (1659 aa, ~186 kDa) is encoded by the human PREX1 gene. This protein is… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Regulatory subunits of protein kinase A (PKA) inhibit its kinase subunits. Intriguingly, their potential as cAMP-dependent signal… Expand
  • figure 2
  • figure 4
  • figure 5
  • figure 7
Highly Cited
2013
Highly Cited
2013
Significance Genetic alterations targeting the PI3K pathway are highly prevalent in breast cancers. Although breast cancers… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 5
  • figure 4
Highly Cited
2011
Highly Cited
2011
Mammalian target of rapamycin complex (mTORC) regulates a variety of cellular responses including proliferation, growth… Expand
  • figure 1
  • figure 2
  • figure 4
  • figure 3
  • figure 5
Highly Cited
2011
Highly Cited
2011
The Neuregulins and their receptors, the ErbB/HER subfamily of receptor tyrosine kinases, have critical roles in animal… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Highly Cited
2011
Highly Cited
2011
Background: PREX1 maps to a Type 2 diabetes susceptibility locus; however, its role in insulin-stimulated GLUT4 trafficking is… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 6
Highly Cited
2010
Highly Cited
2007
Highly Cited
2007
Polarized cell migration results from the transduction of extra-cellular cues promoting the activation of Rho GTPases with the… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Highly Cited
2007
Highly Cited
2007
PI 3,4,5‐trisphosphate [PI(3,4,5)P3; PIP3]‐dependent Rac exchanger 1 (P‐Rex1) is a Rac‐specific guanine nucleotide exchange… Expand
Highly Cited
2006
Highly Cited
2006
Rac activation is a key step in chemotaxis of hematopoietic cells, which is both positively and negatively regulated by receptors… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 6
2005
2005
P-Rex1 is a guanine-nucleotide exchange factor (GEF) for the small GTPase Rac. We have investigated here the mechanisms of… Expand