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Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Rac Exchanger 1 Protein

Known as: P-Rex1, PtdIns(3,4,5)-Dependent Rac Exchanger 1 
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (1659 aa, ~186 kDa) is encoded by the human PREX1 gene. This protein is… Expand
National Institutes of Health

Papers overview

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2018
2018
Regulatory subunits of protein kinase A (PKA) inhibit its kinase subunits. Intriguingly, their potential as cAMP-dependent signal… Expand
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2014
2014
ABSTRACT G-protein-coupled receptors (GPCRs) regulate the organisation of the actin cytoskeleton by activating the Rac subfamily… Expand
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Highly Cited
2013
Highly Cited
2013
Significance Genetic alterations targeting the PI3K pathway are highly prevalent in breast cancers. Although breast cancers… Expand
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Highly Cited
2011
Highly Cited
2011
Mammalian target of rapamycin complex (mTORC) regulates a variety of cellular responses including proliferation, growth… Expand
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2011
2011
Background: PREX1 maps to a Type 2 diabetes susceptibility locus; however, its role in insulin-stimulated GLUT4 trafficking is… Expand
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Highly Cited
2007
Highly Cited
2007
Polarized cell migration results from the transduction of extra-cellular cues promoting the activation of Rho GTPases with the… Expand
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2007
2007
PI 3,4,5-trisphosphate [PI(3,4,5)P3; PIP3]-dependent Rac exchanger 1 (P-Rex1) is a Rac-specific guanine nucleotide exchange… Expand
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2006
2006
Rac activation is a key step in chemotaxis of hematopoietic cells, which is both positively and negatively regulated by receptors… Expand
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2005
2005
P-Rex1 is a guanine-nucleotide exchange factor (GEF) for the small GTPase Rac. We have investigated here the mechanisms of… Expand
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