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Cyclin D1

Known as: Proto-Oncogene Proteins, bcl1, G1/S-Specific Cyclin-D1, Proto Oncogene Products bcl 1 
Protein encoded by the bcl-1 gene which plays a critical role in regulating the cell cycle. Overexpression of cyclin D1 is the result of bcl-1… 
National Institutes of Health

Related topics

Related topics

17 relations
BCL1CCND1 geneCCND1 wt AlleleGenes, bcl-1

Narrower (1)

CCND1 protein, human

Broader (2)

Cyclin DProto-Oncogene Proteins

Papers overview

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Highly Cited
2010
Highly Cited
2010
Transcriptional role of cyclin D1 in development revealed by a genetic–proteomic screen
Cyclin D1 belongs to the core cell cycle machinery, and it is frequently overexpressed in human cancers. The full repertoire of… 
Highly Cited
2009
Highly Cited
2009
Cyclin D1 degradation is sufficient to induce G1 cell cycle arrest despite constitutive expression of cyclin E2 in ovarian cancer cells.
D- and E-type cyclins mediate G(1)-S phase cell cycle progression through activation of specific cyclin-dependent kinases (cdk… 
Highly Cited
1999
Highly Cited
1999
Estrogen induction of the cyclin D1 promoter: involvement of a cAMP response-like element.
Estrogens induce cell proliferation in target tissues by stimulating progression through the G(1) phase of the cell cycle… 
Highly Cited
1995
Highly Cited
1995
Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH 3T3 cells
Ectopic overexpression of v-H-Ras protein in NIH 3T3 cells resulted in cellular transformation and an acceleration of G1… 
Highly Cited
1994
Highly Cited
1994
Induction of cyclin D1 overexpression by activated ras.
Activated ras genes are known to alter control of cell proliferation. This is consistent with the fact that ras proteins are a… 
Highly Cited
1994
Highly Cited
1994
Cyclin D1 protein expression and function in human breast cancer
Cyclin D1 is a cell‐cycle regulator essential for G1, phase progression and a candidate proto‐oncogene implicated in pathogenesis… 
Review
1994
Review
1994
Differential expression and regulation of Cyclin D1 protein in normal and tumor human cells: association with Cdk4 is required for Cyclin D1 function in G1 progression.
In this study we have surveyed by immunoblotting the protein levels of Cyclin D1, D2, D3 and their catalytic partners, Cdk4 and… 
Highly Cited
1994
Highly Cited
1994
Cyclin D1 expression is regulated by the retinoblastoma protein.
The product of the retinoblastoma susceptibility gene, pRb, acts as a tumor suppressor and loss of its function is involved in… 
Highly Cited
1994
Highly Cited
1994
Repression of cyclin D1: a novel function of MYC.
Constitutive expression of human MYC represses mRNA levels of cyclin D1 in proliferating BALB/c-3T3 fibroblasts. We expressed a… 
Highly Cited
1993
Highly Cited
1993
Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E
Cyclin D1 is a G1-specific cyclin that has been linked to lymphoid, parathyroid, and breast tumors. Recent studies suggested that… 
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