Cyclin D

Known as: Cyclins, Type D, D Cyclins, Type, Type D Cyclin 
A cyclin subtype that is specific for CYCLIN-DEPENDENT KINASE 4 and CYCLIN-DEPENDENT KINASE 6. Unlike most cyclins, cyclin D expression is not… (More)
National Institutes of Health

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Highly Cited
2002
Highly Cited
2002
Although mutations that activate the Hedgehog (Hh) signalling pathway have been linked to several types of cancer, the molecular… (More)
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Review
2000
Review
2000
Genetic lesions that disable key regulators of G1 phase progression in mammalian cells are present in most human cancers. Mitogen… (More)
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Highly Cited
1999
Highly Cited
1999
The widely prevailing view that the cyclin-dependent kinase inhibitors (CKIs) are solely negative regulators of cyclin-dependent… (More)
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Highly Cited
1998
Highly Cited
1998
The activities of cyclin D-dependent kinases serve to integrate extracellular signaling during G1 phase with the cell-cycle… (More)
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Highly Cited
1998
Highly Cited
1998
Deregulation of cell proliferation is a hallmark of cancer. In many transformed cells, the cyclin A/CDK2 complex that contains S… (More)
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Highly Cited
1996
Highly Cited
1996
Flavopiridol (L86-8275), a N-methylpiperidinyl, chlorophenyl flavone, can inhibit cell cycle progression in either G1 or G2 and… (More)
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Highly Cited
1995
Highly Cited
1995
Cyclin D-dependent kinases act as mitogen-responsive, rate-limiting controllers of G1 phase progression in mammalian cells. Two… (More)
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Highly Cited
1995
Highly Cited
1995
The elucidation of molecular alterations that occur during human breast cancer progression may contribute to the development of… (More)
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Highly Cited
1993
Highly Cited
1993
The product (pRb) of the retinoblastoma gene (RB-1) prevents S-phase entry during the cell cycle, and inactivation of this growth… (More)
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Highly Cited
1992
Highly Cited
1992
Amplification of the hst-1 and int-2 genes on chromosome 11q13 has previously been found in over 20% of human primary esophageal… (More)
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