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Transcriptional regulation and transformation by Myc proteins
TLDR
A wealth of data has shed new light on the biochemical functions of Myc proteins and on the mechanisms through which they function in cellular transformation. Expand
Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma.
TLDR
AURKA is identified as a gene that is required for the growth of MYCN-amplified neuroblastoma cells but largely dispensable for cells lacking amplified MYCN, and Aurora A has a critical function in regulating turnover of the N-Myc protein. Expand
Repression of p15INK4b expression by Myc through association with Miz-1
TLDR
A Myc-associated transcription factor, Miz-1, arrests cells in G1 phase and inhibits cyclin D-associated kinase activity and upregulates expression of the cyclin-dependent kinases (CDK) inhibitor p15INK4b by binding to the initiator element of the p15inks4b promoter. Expand
Myc's broad reach.
TLDR
The nature of the genes and pathways that are targeted by Myc, and the role of Myc in stem cell and cancer biology are reviewed. Expand
The Ubiquitin Ligase HectH9 Regulates Transcriptional Activation by Myc and Is Essential for Tumor Cell Proliferation
TLDR
It is shown that the E3 ubiquitin ligase HectH9 ubiquitinates Myc in vivo and in vitro, forming a lysine 63-linked polyubiquitin chain, and that Miz1 inhibits this ubiquitination. Expand
Import of proteins into mitochondria.
A mounting body of evidence suggests that cytoplasmically synthesized proteins destined to be imported into the mitochondrial interior must at least partly unfold to penetrate across theExpand
The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells.
TLDR
The beta-catenin/TCF-4 complex constitutes the master switch that controls proliferation versus differentiation in healthy and malignant intestinal epithelial cells. Expand
MYC regulates the antitumor immune response through CD47 and PD-L1
TLDR
MYC regulates the expression of two immune checkpoint proteins on the tumor cell surface: the innate immune regulator CD47 (cluster of differentiation 47) and the adaptive immune checkpoint PD-L1 (programmed death–ligand 1). Expand
The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells
TLDR
The β-catenin/TCF-4 complex constitutes the master switch that controls proliferation versus differentiation in healthy and malignant intestinal epithelial cells. Expand
Negative regulation of the mammalian UV response by Myc through association with Miz-1.
TLDR
Using both c-myc(-/-) cells and a point mutant of Myc that is deficient in Miz-1 dependent repression, it is shown that Myc negatively regulates transcription of p21Cip1 upon UV irradiation and facilitates recovery from UV-induced cell cycle arrest through binding to Miz- 1. Expand
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