Caspase-1

Known as: Interleukin 1beta Converting Enzyme, IL 1 beta Convertase, Interleukin 1-Beta Convertase 
A long pro-domain caspase that has specificity for the precursor form of INTERLEUKIN-1BETA. It plays a role in INFLAMMATION by catalytically… (More)
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Caspase-1 activation by inflammasome scaffolds comprised of intracellular nucleotide-binding oligomerization domain (NOD)-like… (More)
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Highly Cited
2010
Highly Cited
2010
Macrophages mediate crucial innate immune responses via caspase-1-dependent processing and secretion of interleukin 1β (IL-1… (More)
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Highly Cited
2009
Highly Cited
2009
The innate immune system senses nucleic acids by germline-encoded pattern recognition receptors. RNA is sensed by Toll-like… (More)
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Review
2009
Review
2009
The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes secretion of the… (More)
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Highly Cited
2008
Highly Cited
2008
Mammalian cells export most proteins by the endoplasmic reticulum/Golgi-dependent pathway. However, some proteins are secreted… (More)
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Highly Cited
2006
Highly Cited
2006
Gram-negative bacteria that replicate in the cytosol of mammalian macrophages can activate a signaling pathway leading to caspase… (More)
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Highly Cited
2006
Highly Cited
2006
Missense mutations in the CIAS1 gene cause three autoinflammatory disorders: familial cold autoinflammatory syndrome, Muckle… (More)
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Highly Cited
2004
Highly Cited
2004
Specific adaptors regulate the activation of initiator caspases; for example, FADD and Apaf-1 engage caspases 8 and 9… (More)
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Highly Cited
2000
Highly Cited
2000
Huntington disease is an autosomal dominant neurodegenerative disease with no effective treatment. Minocycline is a tetracycline… (More)
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Review
1997
Review
1997
Apoptosis is a major form of cell death, characterized initially by a series of stereotypic morphological changes. In the… (More)
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