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Death receptors: signaling and modulation.
Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique…
Cryopyrin activates the inflammasome in response to toxins and ATP
It is shown that cryopyrin-deficient macrophages cannot activate caspase-1 in response to Toll-like receptor agonists plus ATP, the latter activating the P2X7 receptor to decrease intracellular K+ levels.
Non-canonical inflammasome activation targets caspase-11
It is shown, with C57BL/6 Casp11 gene-targeted mice, that caspase-11 is critical for casp enzyme-1 activation and IL-1β production in macrophages infected with Escherichia coli, Citrobacter rodentium or Vibrio cholerae, and a unique pro-inflammatory role for casingase- 11 in the innate immune response to clinically significant bacterial infections is highlighted.
FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis
Mechanisms and Functions of Inflammasomes
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
It is shown that gasdermin D is essential for caspase-11-dependent pyroptosis and interleukin-1β maturation and a key mediator of the host response against Gram-negative bacteria.
An antagonist decoy receptor and a death domain-containing receptor for TRAIL.
Ectopic expression of TRID protected mammalian cells from TRAIL-induced apoptosis, which is consistent with a protective role.
The Receptor for the Cytotoxic Ligand TRAIL
The DR4-TRAIL axis defines another receptor-ligand pair involved in regulating cell suicide and tissue homeostasis.
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
Interestingly, cell death triggered by stimuli that engage caspase-1 was ablated in macrophages lacking either ASC or Ipaf, suggesting a coupling between the inflammatory and cell death pathways.
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling
A novel ubiquitin ligase domain is defined and two sequential mechanisms by which A20 downregulates NF-κB signalling are identified, both of which participate in mediating a distinct regulatory effect.