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Death receptors: signaling and modulation.
Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique
Cryopyrin activates the inflammasome in response to toxins and ATP
TLDR
It is shown that cryopyrin-deficient macrophages cannot activate caspase-1 in response to Toll-like receptor agonists plus ATP, the latter activating the P2X7 receptor to decrease intracellular K+ levels.
Non-canonical inflammasome activation targets caspase-11
TLDR
It is shown, with C57BL/6 Casp11 gene-targeted mice, that caspase-11 is critical for casp enzyme-1 activation and IL-1β production in macrophages infected with Escherichia coli, Citrobacter rodentium or Vibrio cholerae, and a unique pro-inflammatory role for casingase- 11 in the innate immune response to clinically significant bacterial infections is highlighted.
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
TLDR
It is shown that gasdermin D is essential for caspase-11-dependent pyroptosis and interleukin-1β maturation and a key mediator of the host response against Gram-negative bacteria.
An antagonist decoy receptor and a death domain-containing receptor for TRAIL.
TLDR
Ectopic expression of TRID protected mammalian cells from TRAIL-induced apoptosis, which is consistent with a protective role.
The Receptor for the Cytotoxic Ligand TRAIL
TLDR
The DR4-TRAIL axis defines another receptor-ligand pair involved in regulating cell suicide and tissue homeostasis.
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
TLDR
Interestingly, cell death triggered by stimuli that engage caspase-1 was ablated in macrophages lacking either ASC or Ipaf, suggesting a coupling between the inflammatory and cell death pathways.
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling
TLDR
A novel ubiquitin ligase domain is defined and two sequential mechanisms by which A20 downregulates NF-κB signalling are identified, both of which participate in mediating a distinct regulatory effect.
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