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CASP1 gene

Known as: INTERLEUKIN 1-BETA CONVERTASE, caspase 1, ICE 
This gene plays a role in apoptosis, inflammation, septic shock, and wound healing.
National Institutes of Health

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Related topics

7 relations
ApoptosisCaspase-1HydrolysisProteolysis

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CASP1 wt Allele

Papers overview

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Highly Cited
2014
Highly Cited
2014
Microbial exposure alters HIV-1-induced mucosal CD4+ T cell death pathways Ex vivo
BackgroundEarly HIV-1 infection causes massive CD4+ T cell death in the gut and translocation of bacteria into the circulation… 
2012
2012
YopJ-Induced Caspase-1 Activation in Yersinia-Infected Macrophages: Independent of Apoptosis, Linked to Necrosis, Dispensable for Innate Host Defense
Yersinia outer protein J (YopJ) is a type III secretion system (T3SS) effector of pathogenic Yersinia (Yersinia pestis, Yersinia… 
2011
2011
Borrelia species induce inflammasome activation and IL‐17 production through a caspase‐1‐dependent mechanism
Borrelia burgdorferi spirochetes cause Lyme disease, which can result in severe clinical symptoms such as multiple joint… 
Review
2011
Review
2011
Regulating Caspase-1 During Infection: Roles of NLRs, AIM2, and ASC
Pathogens are detected by a variety of innate immune sensors in host cells leading to rapid induction of cell autonomous… 
2008
2008
Heat shock inhibits caspase‐1 activity while also preventing its inflammasome‐mediated activation by anthrax lethal toxin
Anthrax lethal toxin (LT) rapidly kills macrophages from certain mouse strains in a mechanism dependent on the breakdown of… 
Highly Cited
2006
Highly Cited
2006
Evidence that caspase‐1 is a negative regulator of AMPA receptor‐mediated long‐term potentiation at hippocampal synapses
Best known for their pivotal role in a form of programmed cell death called apoptosis, caspases may also function in more subtle… 
Highly Cited
2004
Highly Cited
2004
Geranylgeraniol Regulates Negatively Caspase-1 Autoprocessing: Implication in the Th1 Response against Mycobacterium tuberculosis1
Caspase-1 is a cysteine protease composed by two 20-kDa and two 10-kDa subunits that processes pro-IL-1β and pro-IL-18 to their… 
Highly Cited
2003
Highly Cited
2003
Coordinate Regulation of IFN Consensus Sequence-Binding Protein and Caspase-1 in the Sensitization of Human Colon Carcinoma Cells to Fas-Mediated Apoptosis by IFN-γ
Interferon-γ is thought to be essential for the regulation of antitumor reactions. However, the degree of responsiveness of… 
2003
2003
Attenuation of increased myocardial ischaemia‐reperfusion injury conferred by hypercholesterolaemia through pharmacological inhibition of the caspase‐1 cascade
Hypercholesterolaemia has been shown to be associated with greater myocardial ischaemia‐reperfusion injury, in which apoptosis… 
2000
2000
Mycobacterial 19-kDa lipoprotein mediates Mycobacterium tuberculosis-induced apoptosis in monocytes/macrophages at early stages of infection
Mycobacterial 19-kDa lipoprotein mediates Mycobacterium tuberculosis -induced apoptosis in monocytes/macrophages at early stages… 
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