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CASP1 gene
Known as:
INTERLEUKIN 1-BETA CONVERTASE
, caspase 1
, ICE
Â
(More)
This gene plays a role in apoptosis, inflammation, septic shock, and wound healing.
National Institutes of Health
Topic mentions per year
Topic mentions per year
1997-2017
0
5
10
1997
2017
Related topics
Related topics
7 relations
Apoptosis
Caspase-1
Hydrolysis
Proteolysis
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Narrower (1)
CASP1 wt Allele
Related mentions per year
Related mentions per year
1936-2018
1940
1960
1980
2000
2020
CASP1 gene
Hydrolysis
inflammatory response
Apoptosis
Proteolysis
Caspase-1
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta.
L. A. B. Joosten
,
Mihai G. Netea
,
+7 authors
Wim B. van den Berg
Arthritis and rheumatism
2009
OBJECTIVE Caspase 1, a known cysteine protease, is a critical component of the inflammasome. Both caspase 1 and neutrophil serine…Â
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Is this relevant?
2008
2008
Evidence of the involvement of caspase-1 under physiologic and pathologic cellular stress during human pregnancy: a link between the inflammasome and parturition.
Francesca Gotsch
,
Roberto Romero
,
+16 authors
Sonia S. Hassan
The journal of maternal-fetal & neonatal medicine…
2008
OBJECTIVE Caspase-1 is a component of the NALP3 inflammasome, a cytosolic multiprotein complex that mediates the processing of…Â
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2008
2008
HMG-CoA reductase inhibition induces IL-1beta release through Rac1/PI3K/PKB-dependent caspase-1 activation.
Loes M. Kuijk
,
Jeffrey Matthijn Beekman
,
Janet Koster
,
H. R. Waterham
,
Joost Frenkel
,
Paul J. Coffer
Blood
2008
Mevalonate kinase deficiency (MKD) is an autoinflammatory disorder characterized by recurring fever episodes and results from…Â
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2007
2007
Broad and specific caspase inhibitor-induced acute repression of apoptosis in atherosclerotic lesions evaluated by radiolabeled annexin A5 imaging.
Masayoshi Sarai
,
Dagmar Hartung
,
+12 authors
Jagat P Narula
Journal of the American College of Cardiology
2007
OBJECTIVES The purpose of this study was to evaluate the role of caspase inhibitors on acute resolution of apoptosis in…Â
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2005
2005
Abundant secretion of bioactive interleukin-1beta by human macrophages induced by Actinobacillus actinomycetemcomitans leukotoxin.
Peyman Kelk
,
Rolf L K Claesson
,
Lennart Hänström
,
U. H. Lerner
,
Sotirios Kalfas
,
Anna L V Johansson
Infection and immunity
2005
Actinobacillus actinomycetemcomitans produces a leukotoxin that selectively kills human leukocytes. Recently, we reported that…Â
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2005
2005
Soluble interleukin-1 receptor type II, IL-18 and caspase-1 in mild cognitive impairment and severe Alzheimer's disease.
Catharina Lindberg
,
Milan Chromek
,
Leif Ahrengart
,
Annelie Brauner
,
Marianne Schultzberg
,
Anita Garlind
Neurochemistry international
2005
In the present study, we have determined levels of soluble interleukin-1 (IL-1) receptor type II (sIL-1RII), interleukin-18 (IL…Â
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2001
2001
Comparison of performance in successive CASP experiments.
ÄŒeslovas Venclovas
,
Adam Zemla
,
Kwasi Fidelis
,
John Moult
Proteins
2001
As the number of completed CASP (Critical Assessment of Protein Structure Prediction) experiments grows, so does the need for…Â
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2000
2000
Functional role and therapeutic implications of neuronal caspase-1 and -3 in a mouse model of traumatic spinal cord injury.
M. Li
,
Victor O. Ona
,
+6 authors
Robert Max Friedlander
Neuroscience
2000
Evidence indicates that both necrotic and apoptotic cell death contribute to tissue injury and neurological dysfunction following…Â
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2000
2000
Role of caspase 1 in neurologic disease.
Robert Max Friedlander
Archives of neurology
2000
I n recent years substantial advances have taken place in understanding the mechanistic pathways mediating neuronal cell death in…Â
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1999
1999
Peripheral levels of caspase-1 mRNA correlate with disease activity in patients with multiple sclerosis; a preliminary study.
R. Furlan
,
M. Filippi
,
+7 authors
G. Martino
Journal of neurology, neurosurgery, and…
1999
The cysteine protease caspase-1 plays a crucial part in the inflammatory process due to its ability to proteolitically activate…Â
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