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CASP1 gene

Known as: INTERLEUKIN 1-BETA CONVERTASE, caspase 1, ICE 
This gene plays a role in apoptosis, inflammation, septic shock, and wound healing.
National Institutes of Health

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Related topics

7 relations
ApoptosisCaspase-1HydrolysisProteolysis

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CASP1 wt Allele

Papers overview

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Highly Cited
2014
Highly Cited
2014
Microbial exposure alters HIV-1-induced mucosal CD4+ T cell death pathways Ex vivo
BackgroundEarly HIV-1 infection causes massive CD4+ T cell death in the gut and translocation of bacteria into the circulation… 
2012
2012
Mifepristone‐Inducible Caspase‐1 Expression in Mouse Embryonic Stem Cells Eliminates Tumor Formation but Spares Differentiated Cells In Vitro and In Vivo
Embryonic stem cell (ESC)‐based therapy is a promising treatment for neurodegenerative diseases. But there is always a risk of… 
2011
2011
Borrelia species induce inflammasome activation and IL‐17 production through a caspase‐1‐dependent mechanism
Borrelia burgdorferi spirochetes cause Lyme disease, which can result in severe clinical symptoms such as multiple joint… 
Review
2011
Review
2011
Regulating Caspase-1 During Infection: Roles of NLRs, AIM2, and ASC
Pathogens are detected by a variety of innate immune sensors in host cells leading to rapid induction of cell autonomous… 
2008
2008
Heat shock inhibits caspase‐1 activity while also preventing its inflammasome‐mediated activation by anthrax lethal toxin
Anthrax lethal toxin (LT) rapidly kills macrophages from certain mouse strains in a mechanism dependent on the breakdown of… 
2006
2006
Topical suplatast tosilate (IPD) ameliorates Th2 cytokine‐mediated dermatitis in caspase‐1 transgenic mice by downregulating interleukin‐4 and interleukin‐5
Background  Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by elevated serum levels of IgE. AD is… 
Highly Cited
2004
Highly Cited
2004
Geranylgeraniol Regulates Negatively Caspase-1 Autoprocessing: Implication in the Th1 Response against Mycobacterium tuberculosis1
Caspase-1 is a cysteine protease composed by two 20-kDa and two 10-kDa subunits that processes pro-IL-1β and pro-IL-18 to their… 
2003
2003
Attenuation of increased myocardial ischaemia‐reperfusion injury conferred by hypercholesterolaemia through pharmacological inhibition of the caspase‐1 cascade
Hypercholesterolaemia has been shown to be associated with greater myocardial ischaemia‐reperfusion injury, in which apoptosis… 
2003
2003
Candidate Gene Approach: Potentional Association of Caspase‐1, Inhibitor of Apoptosis Protein‐1, and Prosaposin Gene Polymorphisms with Response to Salmonella enteritidis Challenge or Vaccination in…
Abstract Salmonella enteritidis (SE) contamination of poultry products is a major cause of food‐borne disease worldwide. Caspase… 
1998
1998
Room temperature-induced apoptosis of Jurkat cells sensitive to both caspase-1 and caspase-3 inhibitors.
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