FAQ

CASP1 gene

Known as: INTERLEUKIN 1-BETA CONVERTASE, caspase 1, ICE 
This gene plays a role in apoptosis, inflammation, septic shock, and wound healing.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1997-2017
051019972017

Related topics

Related topics

7 relations
ApoptosisCaspase-1HydrolysisProteolysis
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CASP1 wt Allele

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
CASP1 gene
Hydrolysis
inflammatory response
Apoptosis
Proteolysis
Caspase-1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta.
OBJECTIVE Caspase 1, a known cysteine protease, is a critical component of the inflammasome. Both caspase 1 and neutrophil serine… (More)
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2008
2008
Evidence of the involvement of caspase-1 under physiologic and pathologic cellular stress during human pregnancy: a link between the inflammasome and parturition.
OBJECTIVE Caspase-1 is a component of the NALP3 inflammasome, a cytosolic multiprotein complex that mediates the processing of… (More)
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2008
2008
HMG-CoA reductase inhibition induces IL-1beta release through Rac1/PI3K/PKB-dependent caspase-1 activation.
Mevalonate kinase deficiency (MKD) is an autoinflammatory disorder characterized by recurring fever episodes and results from… (More)
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2007
2007
Broad and specific caspase inhibitor-induced acute repression of apoptosis in atherosclerotic lesions evaluated by radiolabeled annexin A5 imaging.
OBJECTIVES The purpose of this study was to evaluate the role of caspase inhibitors on acute resolution of apoptosis in… (More)
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2005
2005
Abundant secretion of bioactive interleukin-1beta by human macrophages induced by Actinobacillus actinomycetemcomitans leukotoxin.
Actinobacillus actinomycetemcomitans produces a leukotoxin that selectively kills human leukocytes. Recently, we reported that… (More)
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2005
2005
Soluble interleukin-1 receptor type II, IL-18 and caspase-1 in mild cognitive impairment and severe Alzheimer's disease.
In the present study, we have determined levels of soluble interleukin-1 (IL-1) receptor type II (sIL-1RII), interleukin-18 (IL… (More)
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2001
2001
Comparison of performance in successive CASP experiments.
As the number of completed CASP (Critical Assessment of Protein Structure Prediction) experiments grows, so does the need for… (More)
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2000
2000
Functional role and therapeutic implications of neuronal caspase-1 and -3 in a mouse model of traumatic spinal cord injury.
Evidence indicates that both necrotic and apoptotic cell death contribute to tissue injury and neurological dysfunction following… (More)
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2000
2000
Role of caspase 1 in neurologic disease.
I n recent years substantial advances have taken place in understanding the mechanistic pathways mediating neuronal cell death in… (More)
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1999
1999
Peripheral levels of caspase-1 mRNA correlate with disease activity in patients with multiple sclerosis; a preliminary study.
The cysteine protease caspase-1 plays a crucial part in the inflammatory process due to its ability to proteolitically activate… (More)
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