CASP1 gene

Known as: INTERLEUKIN 1-BETA CONVERTASE, caspase 1, ICE 
This gene plays a role in apoptosis, inflammation, septic shock, and wound healing.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1997-2017
051019972017

Papers overview

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Highly Cited
2009
Highly Cited
2009
OBJECTIVE Caspase 1, a known cysteine protease, is a critical component of the inflammasome. Both caspase 1 and neutrophil serine… (More)
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2008
2008
OBJECTIVE Caspase-1 is a component of the NALP3 inflammasome, a cytosolic multiprotein complex that mediates the processing of… (More)
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2008
2008
Mevalonate kinase deficiency (MKD) is an autoinflammatory disorder characterized by recurring fever episodes and results from… (More)
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2007
2007
OBJECTIVES The purpose of this study was to evaluate the role of caspase inhibitors on acute resolution of apoptosis in… (More)
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2005
2005
Actinobacillus actinomycetemcomitans produces a leukotoxin that selectively kills human leukocytes. Recently, we reported that… (More)
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2005
2005
In the present study, we have determined levels of soluble interleukin-1 (IL-1) receptor type II (sIL-1RII), interleukin-18 (IL… (More)
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2001
2001
As the number of completed CASP (Critical Assessment of Protein Structure Prediction) experiments grows, so does the need for… (More)
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2000
2000
Evidence indicates that both necrotic and apoptotic cell death contribute to tissue injury and neurological dysfunction following… (More)
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2000
2000
I n recent years substantial advances have taken place in understanding the mechanistic pathways mediating neuronal cell death in… (More)
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1999
1999
The cysteine protease caspase-1 plays a crucial part in the inflammatory process due to its ability to proteolitically activate… (More)
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