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CASP1 gene
Known as:
INTERLEUKIN 1-BETA CONVERTASE
, caspase 1
, ICE
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This gene plays a role in apoptosis, inflammation, septic shock, and wound healing.
National Institutes of Health
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Related topics
Related topics
7 relations
Apoptosis
Caspase-1
Hydrolysis
Proteolysis
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CASP1 wt Allele
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Microbial exposure alters HIV-1-induced mucosal CD4+ T cell death pathways Ex vivo
Amanda K. Steele
,
Eric J. Lee
,
+5 authors
Cara C Wilson
Retrovirology
2014
Corpus ID: 2896493
BackgroundEarly HIV-1 infection causes massive CD4+ T cell death in the gut and translocation of bacteria into the circulation…
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2012
2012
Mifepristone‐Inducible Caspase‐1 Expression in Mouse Embryonic Stem Cells Eliminates Tumor Formation but Spares Differentiated Cells In Vitro and In Vivo
Yi Wang
,
Dehua Yang
,
+4 authors
W. Le
Stem Cells
2012
Corpus ID: 13218506
Embryonic stem cell (ESC)‐based therapy is a promising treatment for neurodegenerative diseases. But there is always a risk of…
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2011
2011
Borrelia species induce inflammasome activation and IL‐17 production through a caspase‐1‐dependent mechanism
M. Oosting
,
F. L. van de Veerdonk
,
+7 authors
L. Joosten
European Journal of Immunology
2011
Corpus ID: 25191366
Borrelia burgdorferi spirochetes cause Lyme disease, which can result in severe clinical symptoms such as multiple joint…
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Review
2011
Review
2011
Regulating Caspase-1 During Infection: Roles of NLRs, AIM2, and ASC
Christopher L. Case
The Yale Journal of Biology and Medicine
2011
Corpus ID: 3129138
Pathogens are detected by a variety of innate immune sensors in host cells leading to rapid induction of cell autonomous…
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2008
2008
Heat shock inhibits caspase‐1 activity while also preventing its inflammasome‐mediated activation by anthrax lethal toxin
T. C. Levin
,
K. Wickliffe
,
S. Leppla
,
M. Moayeri
Cellular Microbiology
2008
Corpus ID: 13773995
Anthrax lethal toxin (LT) rapidly kills macrophages from certain mouse strains in a mechanism dependent on the breakdown of…
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2006
2006
Topical suplatast tosilate (IPD) ameliorates Th2 cytokine‐mediated dermatitis in caspase‐1 transgenic mice by downregulating interleukin‐4 and interleukin‐5
T. Murakami
,
Keiichi Yamanaka
,
+4 authors
Hitoshi Mizutani
British Journal of Dermatology
2006
Corpus ID: 32293613
Background Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by elevated serum levels of IgE. AD is…
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Highly Cited
2004
Highly Cited
2004
Geranylgeraniol Regulates Negatively Caspase-1 Autoprocessing: Implication in the Th1 Response against Mycobacterium tuberculosis1
M. T. Montero
,
Joaquín Matilla
,
E. Gómez-Mampaso
,
M. A. Lasunción
Journal of Immunology
2004
Corpus ID: 2612189
Caspase-1 is a cysteine protease composed by two 20-kDa and two 10-kDa subunits that processes pro-IL-1β and pro-IL-18 to their…
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2003
2003
Attenuation of increased myocardial ischaemia‐reperfusion injury conferred by hypercholesterolaemia through pharmacological inhibition of the caspase‐1 cascade
Tzung-Dau Wang
,
Wen‐Jone Chen
,
Tzan-Jr Mau
,
Jong-Wei Lin
,
Wan-Wan Lin
,
Yuan-Teh Lee
British Journal of Pharmacology
2003
Corpus ID: 43132503
Hypercholesterolaemia has been shown to be associated with greater myocardial ischaemia‐reperfusion injury, in which apoptosis…
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2003
2003
Candidate Gene Approach: Potentional Association of Caspase‐1, Inhibitor of Apoptosis Protein‐1, and Prosaposin Gene Polymorphisms with Response to Salmonella enteritidis Challenge or Vaccination in…
W. Liu
,
S. Lamont
Animal Biotechnology
2003
Corpus ID: 46544810
Abstract Salmonella enteritidis (SE) contamination of poultry products is a major cause of food‐borne disease worldwide. Caspase…
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1998
1998
Room temperature-induced apoptosis of Jurkat cells sensitive to both caspase-1 and caspase-3 inhibitors.
M. Shimura
,
E. Okuma
,
+4 authors
Y. Ishizaka
Cancer Letters
1998
Corpus ID: 31052894
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