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A2A adenosine receptor protects tumors from antitumor T cells
TLDR
Although using the hypoxia→adenosine→A2AR pathway inhibitors may improve antitumor immunity, the recruitment of this pathway by selective drugs is expected to attenuate the autoimmune tissue damage. Expand
Tumor-Derived G-CSF Facilitates Neoplastic Growth through a Granulocytic Myeloid-Derived Suppressor Cell-Dependent Mechanism
TLDR
It is demonstrated for the first time that tumor-derived G-CSF enhances tumor growth through granulocytic MDSC-dependent mechanisms. Expand
Baseline tumor growth and immune control in laboratory mice are significantly influenced by subthermoneutral housing temperature
TLDR
It is shown here that fundamental aspects of antitumor immunity in mice are significantly influenced by ambient housing temperature, raising the hypothesis that suppression of antitUMor immunity is an outcome of cold stress-induced thermogenesis. Expand
Irradiation of Tumor Cells Up-Regulates Fas and Enhances CTL Lytic Activity and CTL Adoptive Immunotherapy
TLDR
Results showed for the first time that regulation of the Fas pathway in tumor cells by irradiation plays an important role in their sensitization to Ag-specific CTL; and a combination regimen of tumor-targeted irradiation and CTL promotes more effective antitumor responses in vivo, which may have implications for the combination of immunotherapy and radiation therapy. Expand
Myeloid-derived suppressor cell development is regulated by a STAT/IRF-8 axis.
TLDR
Together, the results reveal a previously unrecognized role for IRF-8 expression in MDSC subset development, which may provide new avenues to target MDSCs in neoplasia. Expand
How tumours escape mass destruction
TLDR
A competent immune system is integral for the control of neoplastic disease, and dissecting the plethora of tumour escape mechanisms that disrupt this essential host defense capability is integral to the development of effective immunotherapeutic paradigms. Expand
Bortezomib and depsipeptide sensitize tumors to tumor necrosis factor-related apoptosis-inducing ligand: a novel method to potentiate natural killer cell tumor cytotoxicity.
TLDR
Findings show that drug-induced sensitization to TRAIL could be used as a novel strategy to potentiate the anticancer effects of adoptively infused NK cells in patients with cancer. Expand
Repression of IFN regulatory factor 8 by DNA methylation is a molecular determinant of apoptotic resistance and metastatic phenotype in metastatic tumor cells.
TLDR
The data suggest that IRF8 is both an essential regulator in Fas-mediated apoptosis pathway and a metastasis suppressor in solid tumors and that metastatic tumor cells use DNA hypermethylation to repress IRf8 expression to evade apoptotic cell death and to acquire a metastatic phenotype. Expand
External Beam Radiation of Tumors Alters Phenotype of Tumor Cells to Render Them Susceptible to Vaccine-Mediated T-Cell Killing
TLDR
A new paradigm for the use of local tumor irradiation in combination with active specific vaccine therapy to elicit durable antitumor responses of established tumors is demonstrated. Expand
Treatment of human colon carcinoma cell lines with anti-neoplastic agents enhances their lytic sensitivity to antigen-specific CD8+ cytotoxic T lymphocytes
TLDR
Certain anti-neoplastic agents may display unique immunoregulatory properties that facilitate human colon carcinoma death by engaging the lytic capacity of Ag-specific CTL, which may have implications for chemoimmunotherapy strategies. Expand
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