Proteolysis

Known as: Degradations, Protein, Degradation, Protein, Protein Degradations 
Proteolysis typically involves hydrolysis of specific peptide bond(s) with formation of smaller polypeptides in a target protein during maturation or… (More)

Topic mentions per year

Topic mentions per year

1938-2017
0500100019382016

Papers overview

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Highly Cited
2003
Highly Cited
2003
Invasive tumor dissemination in vitro and in vivo involves the proteolytic degradation of ECM barriers. This process, however, is… (More)
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Highly Cited
2003
Highly Cited
2003
Rho family GTPases regulate the cytoskeleton and cell migration and are frequently overexpressed in tumours. Here, we identify… (More)
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Highly Cited
2001
Highly Cited
2001
Deleterious processes of extracellular proteolysis may contribute to the progression of tissue damage after acute brain injury… (More)
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Highly Cited
1999
Highly Cited
1999
Hypoxia-inducible factor-1 (HIF-1) has a key role in cellular responses to hypoxia, including the regulation of genes involved in… (More)
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Highly Cited
1999
Highly Cited
1999
The unfolded protein response (UPR) controls the levels of molecular chaperones and enzymes involved in protein folding in the… (More)
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Highly Cited
1998
Highly Cited
1998
The activities of cyclin D-dependent kinases serve to integrate extracellular signaling during G1 phase with the cell-cycle… (More)
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Highly Cited
1997
Highly Cited
1997
Proteolysis mediated by the anaphase-promoting complex (APC) triggers chromosome segregation and exit from mitosis, yet its… (More)
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Highly Cited
1996
Highly Cited
1996
We have identified the yeast and human homologs of the SKP1 gene as a suppressor of cdc4 mutants and as a cyclin F-binding… (More)
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Highly Cited
1995
Highly Cited
1995
I kappa B-alpha inhibits transcription factor NF-kappa B by retaining it in the cytoplasm. Various stimuli, typically those… (More)
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Highly Cited
1977
Highly Cited
1977
A rapid and convenient method for peptide mapping of proteins has been developed. The technique, which is especially suitable for… (More)
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